Entry
Name
D-2-hydroxyacid dehydrogenase (quinone);
(R)-2-hydroxy acid dehydrogenase;
(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase;
D-lactate dehydrogenase (ambiguous)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With a quinone or similar compound as acceptor
BRITE hierarchy
Sysname
(R)-2-hydroxyacid:quinone oxidoreductase
Reaction(IUBMB)
(R)-2-hydroxyacid + a quinone = 2-oxoacid + a quinol [RN:
R10625 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme from mammalian kidney contains one mole of FAD per mole of enzyme.(R)-lactate, (R)-malate and meso-tartrate are good substrates. Ubiquinone-1 and the dye 2,6-dichloroindophenol can act as acceptors; NAD+ and NADP+ are not acceptors.
History
EC 1.1.5.10 created 2014
Reference
Authors
TUBBS PK, GREVILLE GD.
Title
Dehydrogenation of D-lactate by a soluble enzyme from kidney mitochondria.
Journal
Reference
Authors
TUBBS PK, GREVILLE GD
Title
The oxidation of D-alpha-hydroxy acids in animal tissues.
Journal
Reference
Authors
Cammack R
Title
Assay, purification and properties of mammalian D-2-hydroxy acid dehydrogenase.
Journal
Reference
Authors
Cammack R
Title
D-2-hydroxy acid dehydrogenase from animal tissue.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.1.5.10
ExPASy - ENZYME nomenclature database: 1.1.5.10