KEGG   ENZYME: 1.1.5.8
Entry
EC 1.1.5.8                  Enzyme                                 
Name
quinate/shikimate dehydrogenase (quinone);
NAD(P)+-independent quinate dehydrogenase;
quinate:pyrroloquinoline-quinone 5-oxidoreductase;
quinate dehydrogenase (quinone)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With a quinone or similar compound as acceptor
Sysname
quinate:quinol 3-oxidoreductase
Reaction(IUBMB)
quinate + quinone = 3-dehydroquinate + quinol [RN:R09322]
Reaction(KEGG)
R09322 > R01873;
(other) R02415
Substrate
quinate [CPD:C00296];
quinone [CPD:C15602]
Product
3-dehydroquinate [CPD:C00944];
quinol [CPD:C15603]
Comment
The enzyme is membrane-bound. Does not use NAD(P)+ as acceptor. Contains pyrroloquinoline-quinone. cf. EC 1.1.1.24, quinate/shikimate dehydrogenase (NAD+), EC 1.1.1.282, quinate/shikimate dehydrogenase [NAD(P)+], and EC 1.1.1.25, shikimate dehydrogenase (NADP+).
History
EC 1.1.5.8 created 1992 as EC 1.1.99.25, modified 2004, transferred 2010 to EC 1.1.5.8, modified 2021
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K05358  quinate dehydrogenase (quinone)
Genes
ENC: ECL_02057
ENL: A3UG_10890
ECLG: EC036_20890
ECLE: ECNIH2_10510
ECLN: ECNIH4_12015
ECLI: ECNIH5_09660
ECLX: LI66_09885
ECLY: LI62_10650
ECLZ: LI64_09950
ECLO: ENC_12540
EHM: AB284_15150
EXF: BFV63_10065
ECLA: ECNIH3_09670
ECLC: ECR091_09645
EAU: DI57_08075
EKB: BFV64_11120
ENO: ECENHK_10750
EEC: EcWSU1_02121(quiA)
ELG: BH714_06860
ECAN: CWI88_11865
ERN: BFV67_10300
ECLS: LI67_014995
ECHG: FY206_12100
ESH: C1N69_10890
EPT: HWQ17_02860
ENT: Ent638_1963
EAS: Entas_2096
ENX: NI40_010875
LNI: CWR52_01425
EBG: FAI37_18560
END: A4308_15390
ENZ: G0034_10910
ENS: HWQ15_18525
ENK: LOC22_20310
EHU: D5067_0012080
EMOR: L6Y89_10500
ENB: ELK40_11060
EQU: OM418_10640
EPU: QVH39_11165
ESA: ESA_02962
CSK: ES15_3040(quiA)
CSI: P262_04393
CMJ: AFK66_022650
CUI: AFK65_04555
CMW: AFK63_14050
KPN: KPN_01951
KPU: KP1_3018
KPM: KPHS_29290
KPP: A79E_2297
KPH: KPNIH24_13780
KPZ: KPNIH27_14015
KPV: KPNIH29_14675
KPW: KPNIH30_14935
KPY: KPNIH31_13960
KPG: KPNIH32_14830
KPC: KPNIH10_14470
KPQ: KPR0928_14450
KPT: VK055_0527(quiA)
KPO: KPN2242_12685
KPR: KPR_2988(qumA)
KPJ: N559_2336
KPI: D364_10020
KPA: KPNJ1_02519
KPS: KPNJ2_02476
KPX: PMK1_04294(quiA)
KPB: FH42_05855
KPNE: KU54_011685
KPNU: LI86_11620
KPNK: BN49_3047(qumA)
KVA: Kvar_1995 Kvar_2352
KPE: KPK_2122(quiA_1) KPK_2398(quiA_2)
KPK: A593_00510 A593_24630
KVD: KR75_22570 KR75_24295
KVQ: SP68_03280 SP68_04570
KOX: KOX_19605 KOX_22295
KOE: A225_2791 A225_3337
KOY: J415_15275 J415_18020
KOM: HR38_17935 HR38_20615
KOK: KONIH1_13670 KONIH1_16360
KOC: AB185_19520 AB185_21800
KQU: AVR78_18805
EAE: EAE_17560 EAE_20300
EAR: CCG29819 CCG30380
KQV: B8P98_12730
KLL: BJF97_13810 BJF97_16460
KLW: DA718_12480 DA718_15375
KAR: LGL98_11215
KGR: JJJ10_12340 JJJ10_15080
KPAS: LUW96_20130 LUW96_23075
KLC: K7H21_12040 K7H21_13340
KLM: BWI76_13270 BWI76_16705
REE: electrica_02686(quiA)
ROR: RORB6_04655 RORB6_07295
RON: TE10_13320 TE10_16875
RPLN: B1209_11305 B1209_13385
RAO: DSD31_11090 DSD31_13915
RTG: NCTC13098_03956(quiA_3)
PGE: LG71_16020
KOR: AWR26_12245
KRD: A3780_11850
KIE: NCTC12125_01231(quiA_2)
KAS: KATP_20450
KLU: K7B04_18075
KCY: RIN60_10590
LAX: APT61_10515 APT61_15515
LEI: C2U54_17145
LEH: C3F35_04495 C3F35_22780
LEE: DVA44_11390 DVA44_16620
LER: GNG29_11680
LEA: GNG26_11850
LPNU: KQ929_10590
LEY: DVA43_05640 DVA43_10730
LAZ: A8A57_10460
LEF: LJPFL01_2031
LEW: DAI21_15995
BUF: D8682_02485
BAGE: BADSM9389_21630
BFT: MNO13_12985
SGOE: A8O29_010775
KIN: AB182_12705
PDZ: HHA33_14740
METY: MRY16398_29790
IZH: FEM41_15055
PSGC: G163CM_02970(quiA_1) G163CM_13530(quiA_2)
PVJ: LMA04_02065
EBF: D782_1315 D782_2306
EBC: C2U52_23630
EBU: CUC76_01355
PSTS: E05_26620
SMAR: SM39_2615
SPE: Spro_2415
SRR: SerAS9_2394
SRL: SOD_c22460(quiA)
SRY: M621_12355
SPLY: Q5A_012575(quiA)
SRS: SerAS12_2394
SRA: SerAS13_2395
SMAF: D781_1610 D781_2268
SLQ: M495_11955
SERF: L085_12765
SERS: SERRSCBI_11325 SERRSCBI_15450
SFW: WN53_17385
SFG: AV650_12835
SRZ: AXX16_2877 AXX16_3488
SERM: CLM71_07830 CLM71_11720
SQU: E4343_04095
SFJ: SAMEA4384070_2476(quiA)
SOF: NCTC11214_04404(quiA_1)
SSUR: ATE40_012555
SURI: J0X03_07960 J0X03_11975
SRHZ: FO014_02060 FO014_22060
SENP: KHA73_12135
SNEM: NLX84_16045
RAH: Rahaq_4718
RACE: JHW33_25740
RAQ: Rahaq2_4683
RAA: Q7S_24111
ROX: BV494_23725
RVC: J9880_23110
RBON: QNM34_09305
RIU: I2123_23300
GQU: AWC35_09940 AWC35_22055
RBAD: H2866_04930
RCB: O1V66_03870
CARU: P0E69_21445
NIG: C1N62_06170 C1N62_17640
PCT: PC1_2746
PCC: PCC21_028140
PBRA: B5S52_07770
PPUJ: E2566_14365
PARI: I2D83_07675
PCAC: OI450_11720
SOD: Sant_2284
EAM: EAMY_2572(quiA)
EAY: EAM_2469(qumA)
ETA: ETA_10330(quiA)
EPY: EpC_10520(quiA)
EPR: EPYR_01114(quiA)
EBI: EbC_33710(quiA)
ERJ: EJP617_00370(quiA)
EPE: CI789_01525
ERWI: GN242_00930 GN242_05265
ERP: LJN55_01120 LJN55_17265
ETO: RIN69_11615
EGE: EM595_2669(quiA)
PAM: PANA_2853(qumA)
PLF: PANA5342_1191(qumA)
PAJ: PAJ_2140(qumA)
PAQ: PAGR_g1174
PVA: Pvag_2273(quiA)
PAGG: AL522_18405
PAO: Pat9b_1593 Pat9b_2923 Pat9b_4464
KLN: LH22_07925
PANT: PSNIH1_01325
PANP: PSNIH2_03265
PAGC: BEE12_02005
PSTW: DSJ_07565
PALH: B1H58_12550
PANS: FCN45_14200
PEY: EE896_05100
PDIS: D8B20_12685 D8B20_20545 D8B20_20890
PER: LAC65_11855
PJI: KTJ90_05065
PANO: OJ965_07415
KPIE: N5580_04440 N5580_21580
PALF: K6R05_05170
PGZ: C2E15_15850
PCD: C2E16_15585
MINT: C7M51_02340(quiA)
MTHI: C7M52_00516(quiA)
TCI: A7K98_03610 A7K98_14610
TPTY: NCTC11468_02742(quiA_2)
XSA: SB85_14685
XAR: XB05_00790
XTH: G4Q83_19750
XEU: XSP_001224
XHD: LMG31886_31330(quiA_2)
STEK: AXG53_00250 AXG53_18070
SLM: BIZ42_17500
STEM: CLM74_09185
SINC: DAIF1_17950(quiA)
SPAQ: STNY_R17530
STEQ: ICJ04_10905
PWI: MWN52_01390
LGU: LG3211_4849(quiA)
THEH: G7079_11990
LAEO: L2Y97_02455
LAES: L2Y96_01730 L2Y96_02815
VOS: KNV97_08885
PRE: PCA10_30500(quiA)
PCQ: PcP3B5_21730(quiA)
PMUI: G4G71_15850
PNT: G5B91_16225
PPU: PP_3569(quiA)
PPF: Pput_2205
PPG: PputGB1_2352
PPW: PputW619_2956
PPT: PPS_3064
PPB: PPUBIRD1_2225
PPI: YSA_00152
PPX: T1E_2295(qumA)
PPUH: B479_15240
PPUT: L483_18690
PPUN: PP4_21570(quiA) PP4_22620(quiA) PP4_30900(quiA)
PPUD: DW66_3333
PFV: Psefu_2215
PMON: X969_00245 X969_14700
PMOT: X970_14345
PPJ: RK21_01581
PMOL: CLJ08_23845
PALD: LU682_012160
PIX: RIN61_00575
PMOS: O165_007680
PST: PSPTO_2568(gcd-1)
PSP: PSPPH_2927(quiA)
PSAV: PSA3335_17495
PCI: PCH70_28560
PAVL: BKM03_16540
PVD: CFBP1590__3156(qumA)
PCAB: JGS08_15250
PSYI: MME58_11840
PLIJ: KQP88_13720
PFL: PFL_5668(quiA)
PPRC: PFLCHA0_c56200(quiA)
PPRO: PPC_5613
PFO: Pfl01_2712
PFS: PFLU_2304
PFC: PflA506_2235(quiA) PflA506_3610
PPZ: H045_10445
PFB: VO64_5531
PTV: AA957_03040
PVR: PverR02_24080
PAZO: AYR47_18485
POI: BOP93_09955
PRX: HRH33_11255
PKR: AYO71_17085
PMUD: NCTC8068_02504(quiA)
PTOL: I7845_16870
PFW: PF1751_v1c20540(gcd)
PFF: PFLUOLIPICF726445
PFX: A7318_09980
PEN: PSEEN2918(quiA)
PPUU: PputUW4_04960(quiA)
PSV: PVLB_13785 PVLB_23315
PSK: U771_12485
PCZ: PCL1606_05900
PCP: JM49_03040
PCHP: C4K32_5758
PFZ: AV641_12005 AV641_14405
PLQ: AA042_19150
PALK: PSAKL28_18110
PRH: LT40_01715
PSW: LK03_08115
PPV: NJ69_06890
PSES: PSCI_2560
PSEM: TO66_28735
PSEC: CCOS191_2952(qumA)
PPSY: AOC04_07600 AOC04_08960 AOC04_10315
PSOS: POS17_5600
PANR: A7J50_3366 A7J50_3967
PPSL: BJP27_18950
PSIL: PMA3_27675
PYM: AK972_0335 AK972_1429
PKE: DLD99_14185
PUM: HGP31_28590
PGG: FX982_04632
PPSH: G5J76_15495
PGY: AWU82_13635
PEZ: HWQ56_11235 HWQ56_16210 HWQ56_18995
PMAO: PMYSY11_0253(quiA)
PATA: JWU58_13175
PDW: BV82_3572
PZE: HU754_014285
PMOE: HV782_015100
PVW: HU752_017005
PTRT: HU722_0011850
PXA: KSS93_14995
PSAM: HU731_027755
PTZ: HU718_015020
PQI: KH389_14160 KH389_16760 KH389_25040
PXN: HU772_013400
PHV: HU739_004230
PPRG: HU725_012045
PANH: HU763_013385
PFAK: KSS94_12110 KSS94_15835
PMUY: KSS95_16345
PMAM: KSS90_14455
PAZE: KSS91_26365
PORY: EJA05_15760
PZA: HU749_011915
PIE: HU724_015325
PWY: HU734_014890
PTAE: NCTC10697_02340(quiA_1) NCTC10697_02792(quiA_2)
PGF: J0G10_16165
PJU: L1P09_14445
PIZ: LAB08_R55560
PPEG: KUA23_18445
PSII: NF676_14335
PSIH: LOY51_16100
PFIT: KJY40_15260
PASI: LG197_20910
PKM: PZ739_15775
PNB: NK667_30330
PTAI: ICN73_18120
PKK: QQ992_11410
PHYG: JTY93_12370
PPAE: LDL65_21890
PPAO: K3169_17350
PSJY: AA098_11910
EMO: DM558_09245 DM558_09905
PDEN: F1C79_09470
HARR: HV822_05010
MSHE: MAALD49_01580
PSPI: PS2015_677
ACB: A1S_1880
ABM: ABSDF2011(quiA)
ABY: ABAYE1685(quiA)
ABC: ACICU_00688 ACICU_01990
ABN: AB57_2214
ABB: ABBFA_01555(quiA)
ABX: ABK1_0725 ABK1_2458
ABZ: ABZJ_00725 ABZJ_02172
ABR: ABTJ_01718 ABTJ_03085
ABD: ABTW07_0719 ABTW07_2202(quiA)
ABH: M3Q_2338 M3Q_933
ABAD: ABD1_19010(quiA)
ABJ: BJAB07104_00737 BJAB07104_01748
ABAB: BJAB0715_02136
ABAJ: BJAB0868_00745 BJAB0868_02129
ABAZ: P795_7610
ABK: LX00_10075
ABAU: IX87_20860
ABAA: IX88_11575
ABW: BL01_00645 BL01_18290
ABAL: ABLAC_27530
ACC: BDGL_001359(quiA)
ANO: RR32_08455
ALC: OTEC02_08085
ACAL: BUM88_10780
ASEI: I8T81_08350
ACD: AOLE_08450
ACI: ACIAD1716(quiA)
AJO: RZ95_12730
ACW: A0J50_07810
AHL: AHTJS_06230
ASOL: BEN76_04820
ALA: BFG52_11650
AWU: BEN71_12820
AGU: AS4_11920(quiA)
AUG: URS_1503
ADS: FPL17_02780
ABER: BSR55_05750
ATN: FM020_09715
ACHI: CDG60_12015
AVB: RYU24_10660
ABOU: ACBO_10090(quiA) ACBO_10650
AGYL: FPL18_19090
ACIU: A3K93_07705
AVZ: HWI77_09950
ATZ: M5E07_10080
ACOI: NQU59_15040
AVIV: LF296_10810
ACIE: KIP84_08000
SNAN: I6N98_06640
STAW: NCG89_06895
KIM: G3T16_00410
TDU: QJT80_12965
HHU: AR456_12670
HAA: A5892_00305 A5892_13310 A5892_16365
ADI: B5T_01333
AXE: P40_06280
ORB: IPMB12_01915 IPMB12_10245
SALV: SALWKB2_0342
BAM: Bamb_5932
BUB: BW23_5775
BMEC: WJ16_18565
BCAI: K788_0002020
PHS: C2L64_43480
PTER: C2L65_40770
PTRO: G5S35_16920
PGIS: I6I06_19805
PACS: FAZ98_17630
PSAA: QEN71_38790
PLG: NCTC10937_02880(quiA)
CABK: NK8_79940
BHO: D560_0057
BHM: D558_0055
BHZ: ACR54_01234(quiA_1)
BPDZ: BBN53_15570
BOJ: CBF45_03175 CBF45_03590
ACHO: H4P35_13430
AMUI: PE062_10145
PUT: PT7_3097
AKA: TKWG_01470
AMIM: MIM_c02450 MIM_c38430(quiA)
ODI: ODI_R0482 ODI_R4076
PIG: EGT29_22040
PACR: FXN63_04375
KGY: EHF36_03600 EHF36_04110
AAA: Acav_1444
VAM: C4F17_14355
CTT: CtCNB1_1086 CtCNB1_2810
CTES: O987_05955 O987_16865
CKE: B5M06_09610
CAQT: KAQ61_12790
CTEZ: CT3_18170 CT3_26160 CT3_35870(gcd-1)
AANT: HUK68_07940 HUK68_11805 HUK68_19800
HYN: F9K07_14735
JAZ: YQ44_13085
JAL: BZG29_14445
JSV: CNX70_15035
JAS: FJQ89_04005
JLV: G3257_15335 G3257_15500
JAH: JAB4_030360(quiA)
JRI: P9875_15135
MASW: AM586_14025
MUM: FCL38_08080
XYK: GT347_06455 GT347_26100
XYG: R9X41_13635 R9X41_17120
MLN: A9174_11175
MESR: FGU64_17975
HOE: IMCC20628_03545 IMCC20628_04865
AAK: AA2016_2351
AMIH: CO731_02353(quiA)
AMIS: Amn_40910
ANJ: AMD1_2247(quiA)
ATU: Atu3354
ATA: AWN88_03700
AGR: AGROH133_11291
ATF: Ach5_32060
AGT: EYD00_21000
ARUI: G6M88_12885
AVV: RvVAT039_36500
AVF: RvVAR031_39170
RIR: BN877_II1480(qumA)
RPUS: CFBP5875_21225
ALEG: CFBP4996_16255
AVI: Avi_5248
RET: RHE_CH03394
REL: REMIM1_CH03455
RLE: RL3832(quiA)
RLT: Rleg2_3145
RLG: Rleg_3417
RLB: RLEG3_27630
RLU: RLEG12_27020
RHN: AMJ98_CH03590
RHX: AMK02_CH03478
RHV: BA939_18740
RHK: Kim5_CH03673
REZ: AMJ99_CH03639
RGR: FZ934_26905
RAD: CO657_16125
ROY: G3A56_18500
RII: FFM53_017845
RHID: FFM81_004110
RLN: J0663_04705
RBAN: J2J98_17125
RRG: J3P73_19765
RAW: NE851_28700
RLW: RlegWSM1455_17170
RRHO: PR018_25315
RBW: RLCC275e_17565
RIF: U5G49_003497
NEN: NCHU2750_18800(quiA) NCHU2750_31460(quiA)
KAI: K32_33720(gcd-1)
BAPI: BBC0122_003300 BBC0122_014360
BAPA: BBC0178_003270 BBC0178_014530
AALA: IGS74_19985
AALM: LUX29_22345
CMB: CSW64_08740
CFH: C1707_10140
CAUL: KCG34_16830
APAH: KB221_07185
DSH: Dshi_2294
KRO: BVG79_p1000055(gcd)
YAN: AYJ57_19690
TPRO: Ga0080559_TMP4533
PARO: CUV01_13145 CUV01_14210
PAMN: pAMV3p0147(quiA)
PAEX: JHW48_15610
PALP: JHW40_19325
PAEZ: PAE61_05750
PPRU: FDP22_10835
LVR: T8T21_17195
NRE: BES08_19205
NOV: TQ38_025290
SPHK: SKP52_01135
SPHM: G432_16325
SBIN: SBA_ch1_21670(gcd-1_1) SBA_ch1_21730(gcd-1_2)
SNOS: K8P63_12755 K8P63_18365 K8P63_19135
SABI: PBT88_13005
SCH: Sphch_3281
SHYD: CJD35_06445
SYA: A6768_04825
SPYG: YGS_C2P0383
SPPH: KFK14_08080
ACOB: P0Y56_07660 P0Y56_07685 P0Y56_15125
CAEN: K5X80_04025
GOX: GOX1857
GOY: GLS_c14360(quiA1) GLS_c19740(quiA2)
GFA: MKW11_13320
APT: APA01_21550
APW: APA42C_21550
APF: APA03_21550
APU: APA07_21550
APG: APA12_21550
APQ: APA22_21550
APX: APA26_21550
APZ: APA32_21550
APK: APA386B_1016(gcd)
ASZ: ASN_2084
AACE: A0U92_00185
ATO: CIW82_02005
AOT: AcetOri_orf04113
AOY: EOV40_010350
ACEK: FLP30_06265
ABG: Asbog_00451
RGI: RGI145_11815
NEH: E3E11_03170
PARH: I5S86_16275
SLOM: PXH66_07045 PXH66_10400
LLH: I41_37900(quiA)
TPOL: Mal48_46890(quiA)
HBS: IPV69_01825
ADIN: H7849_11325 H7849_14420 H7849_20325
SUS: Acid_1183
PFER: IRI77_32580 IRI77_32910
GPH: GEMMAAP_11605
GGR: HKW67_03900 HKW67_09990 HKW67_18680
COY: HF329_13475
FLC: KJS93_09750
THEO: IMW88_10050
MDJ: LLH06_07640
ALGO: GYM62_14460
SOQ: LQ777_25405
SENF: GJR95_36005
DPF: ON006_06260
IRO: RT717_00835 RT717_14240
PRHO: PZB74_00680
TPEL: P0M28_05720 P0M28_25320
SMIS: LDL76_09390
 » show all
Reference
1  [PMID:3044290]
  Authors
van Kleef MA, Duine JA.
  Title
Bacterial NAD(P)-independent quinate dehydrogenase is a quinoprotein.
  Journal
Arch Microbiol 150:32-6 (1988)
DOI:10.1007/bf00409714
Reference
2  [PMID:14586099]
  Authors
Adachi O, Tanasupawat S, Yoshihara N, Toyama H, Matsushita K
  Title
3-dehydroquinate production by oxidative fermentation and further conversion of 3-dehydroquinate to the intermediates in the shikimate pathway.
  Journal
Biosci Biotechnol Biochem 67:2124-31 (2003)
DOI:10.1271/bbb.67.2124
Reference
3  [PMID:15598527]
  Authors
Vangnai AS, Toyama H, De-Eknamkul W, Yoshihara N, Adachi O, Matsushita K
  Title
Quinate oxidation in Gluconobacter oxydans IFO3244: purification and characterization of quinoprotein quinate dehydrogenase.
  Journal
FEMS Microbiol Lett 241:157-62 (2004)
DOI:10.1016/j.femsle.2004.10.014
Other DBs
ExplorEnz - The Enzyme Database: 1.1.5.8
IUBMB Enzyme Nomenclature: 1.1.5.8
ExPASy - ENZYME nomenclature database: 1.1.5.8
BRENDA, the Enzyme Database: 1.1.5.8
CAS: 115299-99-5

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