KEGG ENZYME: 1.1.7.1

ENZYME: 1.1.7.1

Entry

EC 1.1.7.1                  Enzyme

Name

4-hydroxybenzoyl-CoA reductase;
4-hydroxybenzoyl-CoA reductase (dehydroxylating);
4-hydroxybenzoyl-CoA:(acceptor) oxidoreductase;
benzoyl-CoA:acceptor oxidoreductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With an iron-sulfur protein as acceptor

Sysname

benzoyl-CoA:oxidized ferredoxin oxidoreductase

Reaction(IUBMB)

benzoyl-CoA + oxidized ferredoxin + H2O = 4-hydroxybenzoyl-CoA + reduced ferredoxin [RN:R05316]

Reaction(KEGG)

R05316

Substrate

benzoyl-CoA [CPD:C00512];
oxidized ferredoxin [CPD:C00139];
H2O [CPD:C00001]

Product

4-hydroxybenzoyl-CoA [CPD:C02949];
reduced ferredoxin [CPD:C00138]

Comment

A molybdenum-flavin-iron-sulfur protein that is involved in the anaerobic pathway of phenol metabolism in bacteria. A ferredoxin with two [4Fe-4S] clusters functions as the natural electron donor [3].

History

EC 1.1.7.1 created 2000 as EC 1.3.99.20, transferred 2011 to EC 1.3.7.9, transferred 2020 to EC 1.1.7.1

Pathway

ec00362

Benzoate degradation

ec00627

Aminobenzoate degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K04107

4-hydroxybenzoyl-CoA reductase subunit gamma

K04108

4-hydroxybenzoyl-CoA reductase subunit alpha

K04109

4-hydroxybenzoyl-CoA reductase subunit beta

Genes

EBA:	ebA3602(hcrB) ebA3603(hcrA) ebA3604(hcrC)

ABRE:

pbN1_21960(hcrB) pbN1_21970(hcrA) pbN1_21980(hcrC)

APET:

ToN1_29630(hcrB) ToN1_29640(hcrA) ToN1_29650(hcrC)

AZA:	AZKH_0489(hcrB) AZKH_0490(hcrA) AZKH_0491(hcrC)

AZI:	AzCIB_0406 AzCIB_0407 AzCIB_0408

AZD:	CDA09_02105(hcrB) CDA09_02110(hcrA) CDA09_02115(hcrC)

TMZ:	Tmz1t_0224 Tmz1t_0225 Tmz1t_0226

TCL:	Tchl_2357 Tchl_2358 Tchl_2359

TAK:	Tharo_1513 Tharo_1514 Tharo_1515

DDZ:	DSYM_17590 DSYM_17600 DSYM_17610

RPA:	TX73_003470(hcrC) TX73_003475(hcrA) TX73_003480(hcrB)

RPC:	RPC_1013 RPC_1014 RPC_1015

RPD:	RPD_1523 RPD_1524 RPD_1525

RPE:	RPE_0589 RPE_0590 RPE_0591

RPT:	Rpal_0737 Rpal_0738 Rpal_0739

RPX:	Rpdx1_4114 Rpdx1_4115 Rpdx1_4116

MAGX:

XM1_2739(hcrC) XM1_2740(hcrA) XM1_2741(hcrB)

MAGN:

WV31_19855 WV31_19860 WV31_19865

MAG:	amb2019 amb2020 amb2021

PAUU:

E8A73_015075

FWA:	DCMF_00940

BLAR:

LC508_05745

SVIO:

HWN34_02715

SAIU:

J4H86_06065

AMAZ:

LUW76_45490

UAM:	UABAM_02437

» show all

Reference

1 [PMID:2753161]

Authors

Glockler R, Tschech A, Fuchs G.

Title

Reductive dehydroxylation of 4-hydroxybenzoyl-CoA to benzoyl-CoA in a denitrifying, phenol-degrading Pseudomonas species.

Journal

FEBS Lett 251:237-40 (1989)
DOI:10.1016/0014-5793(89)81461-9

Reference

2 [PMID:9683649]

Authors

Heider J, Boll M, Breese K, Breinig S, Ebenau-Jehle C, Feil U, Gad'on N, Laempe D, Leuthner B, Mohamed ME, Schneider S, Burchhardt G, Fuchs G.

Title

Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica.

Journal

Arch Microbiol 170:120-31 (1998)
DOI:10.1007/s002030050623

Reference

3 [PMID:9490068]

Authors

Breese K, Fuchs G

Title

4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from the denitrifying bacterium Thauera aromatica--prosthetic groups, electron donor, and genes of a member of the molybdenum-flavin-iron-sulfur proteins.

Journal

Eur J Biochem 251:916-23 (1998)
DOI:10.1046/j.1432-1327.1998.2510916.x

Sequence

[ag:CAA05038 CAA05039 CAA05037]

Reference

4 [PMID:8477729]

Authors

Brackmann R, Fuchs G.

Title

Enzymes of anaerobic metabolism of phenolic compounds. 4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from a denitrifying Pseudomonas species.

Journal

Eur J Biochem 213:563-71 (1993)
DOI:10.1111/j.1432-1033.1993.tb17795.x