KEGG   ENZYME: 1.1.99.27
Entry
EC 1.1.99.27                Enzyme                                 
Name
(R)-pantolactone dehydrogenase (flavin);
2-dehydropantolactone reductase (flavin);
2-dehydropantoyl-lactone reductase (flavin);
(R)-pantoyllactone dehydrogenase (flavin)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
Sysname
(R)-pantolactone:acceptor oxidoreductase (flavin-containing)
Reaction(IUBMB)
(R)-pantolactone + acceptor = 2-dehydropantolactone + reduced acceptor [RN:R03156]
Reaction(KEGG)
R03156
Substrate
(R)-pantolactone [CPD:C01012];
acceptor [CPD:C00028]
Product
2-dehydropantolactone [CPD:C01125];
reduced acceptor [CPD:C00030]
Comment
High specificity for (R)-pantolactone. Phenazine methosulfate (PMS) can act as acceptor. The enzyme has been studied in the bacterium Nocardia asteroides and shown to be membrane-bound and induced by 1,2-propanediol. The FMN cofactor is non-covalently bound.
History
EC 1.1.99.27 created 1999
Reference
1  [PMID:1541293]
  Authors
Kataoka M, Shimizu S, Yamada H.
  Title
Purification and characterization of a novel FMN-dependent enzyme. Membrane-bound L-(+)-pantoyl lactone dehydrogenase from Nocardia asteroides.
  Journal
Eur J Biochem 204:799-806 (1992)
DOI:10.1111/j.1432-1033.1992.tb16698.x
Other DBs
ExplorEnz - The Enzyme Database: 1.1.99.27
IUBMB Enzyme Nomenclature: 1.1.99.27
ExPASy - ENZYME nomenclature database: 1.1.99.27
BRENDA, the Enzyme Database: 1.1.99.27
CAS: 140879-14-7

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (1)   
   UniProt (1)   
DNA sequence (2)   
   GenBank (1)   
   EMBL (1)   
All databases (9)   

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