KEGG ENZYME: 1.1.99.35

ENZYME: 1.1.99.35

Entry

EC 1.1.99.35                Enzyme

Name

soluble quinoprotein glucose dehydrogenase;
soluble glucose dehydrogenase;
sGDH;
glucose dehydrogenase (PQQ-dependent)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors

Sysname

D-glucose:acceptor oxidoreductase

Reaction(IUBMB)

D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor [RN:R10411]

Reaction(KEGG)

R10411

Substrate

D-glucose [CPD:C00031];
acceptor [CPD:C00028]

Product

D-glucono-1,5-lactone [CPD:C00198];
reduced acceptor [CPD:C00030]

Comment

Soluble periplasmic enzyme containing a tightly-bound PQQ cofactor that is bound to a calcium ion. As the electron acceptor is not known, the enzyme has been assayed with Wurster's Blue or phenazine methosulfate. It has negligible sequence or structure similarity to other quinoproteins. It catalyses an exceptionally high rate of oxidation of a wide range of aldose sugars, including D-glucose, galactose, arabinose and xylose, and also the disaccharides lactose, cellobiose and maltose. It has been described only in Acinetobacter calcoaceticus.

History

EC 1.1.99.35 created 2010

Reference

Authors

Geiger, O. and Gorisch, H.

Title

Crystalline quinoprotein glucose dehydrogenase from Acinetobacter calcoaceticus.

Journal

Biochemistry 25:6043-6048 (1986)

Reference

2 [PMID:3800975]

Authors

Dokter P, Frank J, Duine JA

Title

Purification and characterization of quinoprotein glucose dehydrogenase from Acinetobacter calcoaceticus L.M.D. 79.41.

Journal

Biochem J 239:163-7 (1986)
DOI:10.1042/bj2390163

Reference

3 [PMID:2834325]

Authors

Cleton-Jansen AM, Goosen N, Wenzel TJ, van de Putte P

Title

Cloning of the gene encoding quinoprotein glucose dehydrogenase from Acinetobacter calcoaceticus: evidence for the presence of a second enzyme.

Journal

J Bacteriol 170:2121-5 (1988)
DOI:10.1128/JB.170.5.2121-2125.1988

Reference

4 [PMID:2551369]

Authors

Matsushita K, Shinagawa E, Adachi O, Ameyama M

Title

Quinoprotein D-glucose dehydrogenase of the Acinetobacter calcoaceticus respiratory chain: membrane-bound and soluble forms are different molecular species.

Journal

Biochemistry 28:6276-80 (1989)
DOI:10.1021/bi00441a020

Reference

5 [PMID:10933491]

Authors

Oubrie A, Dijkstra BW

Title

Structural requirements of pyrroloquinoline quinone dependent enzymatic reactions.

Journal

Protein Sci 9:1265-73 (2000)
DOI:10.1110/ps.9.7.1265

Reference

Authors

Matsushita, K., Toyama, H., Ameyama, M., Adachi, O., Dewanti, A. and Duine, J.A.

Title

Soluble and membrane-bound quinoprotein D-glucose dehydrogenases of the Acinetobacter calcoaceticus : the binding process of PQQ to the apoenzymes.

Journal

Biosci Biotechnol Biochem 59:1548-1555 (1995)

Other DBs

ExplorEnz - The Enzyme Database:

1.1.99.35

IUBMB Enzyme Nomenclature:

1.1.99.35

ExPASy - ENZYME nomenclature database:

1.1.99.35

BRENDA, the Enzyme Database:

1.1.99.35

All links

Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (19)   
   UniProt (18)   
   SWISS-PROT (1)   
DNA sequence (36)   
   GenBank (18)   
   EMBL (18)   
Protein domain (5)   
   InterPro (5)   
All databases (66)   

Download RDF

DBGET integrated database retrieval system