Entry
Name
D-2-hydroxyglutarate dehydrogenase;
D2HGDH (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
(R)-2-hydroxyglutarate:acceptor 2-oxidoreductase
Reaction(IUBMB)
(R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor [RN:
R10575 ]
Reaction(KEGG)
Substrate
Product
Comment
Contains FAD. The enzyme has no activity with NAD+ or NADP+, and was assayed in vitro using artificial electron acceptors. It has lower activity with (R)-lactate, (R)-2-hydroxybutyrate and meso-tartrate, and no activity with the (S) isomers. The mammalian enzyme is stimulated by Zn2+, Co2+ and Mn2+.
History
EC 1.1.99.39 created 2013
Orthology
K18204 D-2-hydroxyglutarate dehydrogenase
Genes
MORG : 121433542 121446704
CTIG : 120297675(D2HGDH) 120319511
CIDE : 127494575 127524593
MANU : 129442888 129442889
SASA : 106574512 106575380
BBEL : 109465653 109479756
LPIC : 129276480 129276490
DSI : Dsimw501_GD16587(Dsim_GD16587)
CCAT : 101452249 101452433
SCAC : 106093131 106093133
LSQ : 119599689 119599706 119599803 119599816
AGRG : 126743880 126745773
CSET : 123311542 123313207
AGB : 108909935 108909939 108909941 111692762
LDC : 111508459 111514468 111514684
APLN : 108736897 108736919
PPYR : 116170989 116170991
SLIU : 111349619 111349620
CFEL : 113367308 113367311
ACOO : 126834727 126836239
HHAL : 106677210 106677211
MQU : 128985791 128992366 128992688 128993510
TPAL : 117641822 117642329 117645170
PTRU : 123515392 123515397
PPOI : 119089496 119089542 119089543 119098540 119106195
LPOL : 106470011 106471714
PMEO : 129583835 129583924 129583992
CEL : CELE_F54D5.12(dhgd-1)
MMER : 123526408 128551545
TAD : TRIADDRAFT_31230 TRIADDRAFT_60696
CSAT : 104716494 104721134 104729545
EUS : EUTSA_v10000690mg EUTSA_v10024815mg
HSYR : 120159588 120185549
PVU : PHAVU_002G112400g PHAVU_005G099900g
PSAT : 127095029 127120190
LJA : Lj2g3v1728750.1(Lj2g3v1728750.1)
AHF : 112717690 112749493 112800773
SSPL : 121774821 121777170
TAES : 123046715 123054564 123190424
PVIR : 120659565 120664339
SMO : SELMODRAFT_76083 SELMODRAFT_83489
MPP : MICPUCDRAFT_36867(JGI:MicpuC2_36867)
TET : TTHERM_00332200 TTHERM_00825650
PTM : GSPATT00036991001 GSPATT00036992001
SMIN : v1.2.004695.t1(symbB.v1.2.004695.t1)
PTI : PHATRDRAFT_20192(D-LCR)
PIF : PITG_02245 PITG_02246
PSOJ : PHYSODRAFT_284590 PHYSODRAFT_310261
» show all
Taxonomy
Reference
Authors
Engqvist M, Drincovich MF, Flugge UI, Maurino VG
Title
Two D-2-hydroxy-acid dehydrogenases in Arabidopsis thaliana with catalytic capacities to participate in the last reactions of the methylglyoxal and beta-oxidation pathways.
Journal
Sequence
Reference
Authors
Achouri Y, Noel G, Vertommen D, Rider MH, Veiga-Da-Cunha M, Van Schaftingen E
Title
Identification of a dehydrogenase acting on D-2-hydroxyglutarate.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.99.39