KEGG   ENZYME: 1.1.99.40
Entry
EC 1.1.99.40                Enzyme                                 
Name
(R)-2-hydroxyglutarate---pyruvate transhydrogenase;
DLD3 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
Sysname
(R)-2-hydroxyglutarate:pyruvate oxidoreductase [(R)-lactate-forming]
Reaction(IUBMB)
(R)-2-hydroxyglutarate + pyruvate = 2-oxoglutarate + (R)-lactate [RN:R11593]
Reaction(KEGG)
R11593
Substrate
(R)-2-hydroxyglutarate [CPD:C01087];
pyruvate [CPD:C00022]
Product
2-oxoglutarate [CPD:C00026];
(R)-lactate [CPD:C00256]
Comment
The enzyme, characterized in the yeast Saccharomyces cerevisiae, also functions as EC 1.1.2.4, D-lactate dehydrogenase (cytochrome), and is active with oxaloacetate as electron acceptor forming (R)-malate.
History
EC 1.1.99.40 created 2017
Pathway
ec00620  Pyruvate metabolism
ec01100  Metabolic pathways
Orthology
K21618  (R)-2-hydroxyglutarate---pyruvate transhydrogenase
Genes
AJC117101910
SCEYDL178W(DLD2) YEL071W(DLD3)
SEUBDI49_0901 DI49_5679
SPAOSPAR_D00650 SPAR_E00030
AGOAGOS_ACL021C
ERCEcym_8034
KLAKLLA0_F05753g
KMXKLMA_60482(DLD2)
LTHKLTH0A05280g
ZROZYRO0C09218g
CGRCAGL0J06314g
NCSNCAS_0E03520(NCAS0E03520) NCAS_0H00160(NCAS0H00160)
NDINDAI_0A03060(NDAI0A03060) NDAI_0H04030(NDAI0H04030)
TPFTPHA_0A03280(TPHA0A03280)
TBLTBLA_0F01970(TBLA0F01970)
TGBHG536_0C05350 HG536_0G04870
TDLTDEL_0A08020(TDEL0A08020) TDEL_0E05730(TDEL0E05730) TDEL_0H01580(TDEL0H01580)
KAFKAFR_0L01170(KAFR0L01170)
KNGKNAG_0B02950(KNAG0B02950)
ZMKHG535_0C06490 HG535_0G01630
PPAPAS_chr3_0674
DHADEHA2B10142g
PICPICST_89565(DLD2)
PGUPGUG_01680
SPAASPAPADRAFT_51529
LELPVL30_002082(DLD2)
CALCAALFM_C303040WA(AIP2)
CTPCTRG_02583
COTCORT_0B03720
CDUCD36_83020
CTENCANTEDRAFT_103656
YLIYALI0C06446g
CLUCLUG_05807
CLUSA9F13_05g01430
CAURCJI96_0000621
SLBAWJ20_5329(DLD2)
PKZC5L36_0A01180
BNNFOA43_004635(DLD2)
BBRXBRETT_001775
OPAHPODL_02835
SLUDSCDLUD_000314
NCRNCU06441
NTENEUTE1DRAFT146088(NEUTE1DRAFT_146088)
SMPSMAC_02202
PANPODANSg5397
PBELQC761_709950(DLD2)
PPSDQC762_709950(DLD2)
PPSPQC763_709950(DLD2)
PPSAQC764_709950(DLD2)
TTTTHITE_2119881
MTMMYCTH_2303826
CTHRCTHT_0069840
MGRMGG_12830
PPEIPpBr36_06064
PGRIPgNI_00884
TMNUCRPA7_2227
SSCKSPSK_03231
FGRFGSG_13110
FPUFPSE_01095
FPOAFPOAC1_011061
FVNFVRRES_12081
FVRFVEG_05295
FOXFOXG_02132
NHENECHADRAFT_68595
FKRNCS57_00622200
FMUJ7337_002466
TRETRIREDRAFT_76013
TRRM419DRAFT_23753
MAWMAC_00625
MAJMAA_05955
PCHMVFPPC_02734
CMTCCM_01480
AMUSLMH87_004156
PLJVFPFJ_05626
PTKZJDV02_000856(DLD2_2)
VALVDBG_02828
VDAVDAG_03746
CFJCFIO01_10052
CLUPCLUP02_03998
CHIGCH63R_02967
SAPOSAPIO_CDS5745
ELAUCREL1_1651
PFYPFICI_11909
SSLSS1G_07702
BFUBCIN_15g02730
MBEMBM_06930
PSCOLY89DRAFT_60738
GLZGLAREA_06857
ANIANIA_11045
AFMAFUA_5G02230
ACTACLA_003010
NFINFIA_039880
AORAO090102000291
ANGAn02g10670
AFVAFLA_011734
ALUCAKAW2_10900S
ACHEACHE_51025S
APUUAPUU_41540A
PCSN7525_008041
PDPPDIP_48140
POUPOX_a00075
TMFEYB26_004184
TRGTRUGW13939_08504
CIMCIMG_06424
CPWCPC735_029240
UREUREG_03983
PBLPAAG_07804
PBNPADG_02733
ABEARB_00809
TVETRV_00678
AJEHCAG_00349
BGHBDBG_01546
PNOSNOG_11128
PTEPTT_18111
BZECOCCADRAFT_5082
BSCCOCSADRAFT_82172
BORCOCMIDRAFT_93512
AALTCC77DRAFT_741863
ARABEKO05_0009888
ZTRMYCGRDRAFT_74344
PFJMYCFIDRAFT_215437
FFUCLAFUR5_06940
CBETCB0940_09722
BCOMBAUCODRAFT_150031
NPAUCRNP2_192
TMLGSTUM_00011704001
SPOSPBC713.03
SOMSOMG_01473(dld2)
CNECNB01750 CNK01540
CNBCNBB3980 CNBK2000
CNGCNAG_02664 CNAG_03676
CGICGB_B5760W CGB_K2470C
CDEUCNBG_0079 CNBG_3125
TMSTREMEDRAFT_44101
TASAA1Q1_08226
CCACCcaHIS019_0209500(DLD2)
TVSTRAVEDRAFT_159410 TRAVEDRAFT_16748
DSQDICSQDRAFT_75448
PCOPHACADRAFT_180107
SHSSTEHIDRAFT_117557
HIRHETIRDRAFT_307493
PSQPUNSTDRAFT_58716
ADLAURDEDRAFT_111902
FMEFOMMEDRAFT_121754
GTRGLOTRDRAFT_31335
RSXRhiXN_00802
LBCLACBIDRAFT_175753
CCICC1G_03657
ABPAGABI1DRAFT110375(AGABI1DRAFT_110375)
ABVAGABI2DRAFT60921(AGABI2DRAFT_60921)
PCUBJR316_0000843
MRRMoror_99
MOREE1B28_001223
SCMSCHCO_02609927(SCHCODRAFT_02609927)
CPUTCONPUDRAFT_115042
SLASERLADRAFT_358276 SERLADRAFT_456132
WSEWALSEDRAFT_58973
WICJ056_004400
UMAUMAG_01314
PFPPFL1_04079
SGRAEX895_001713
MGLMGL_2442
MRTMRET_3321
MSYMMSY001_1771
PGRPGTG_05096
PTRCPtA15_3A252
PSTRPst134EA_007528
MLRMELLADRAFT_49675
 » show all
Reference
1  [PMID:26774271]
  Authors
Becker-Kettern J, Paczia N, Conrotte JF, Kay DP, Guignard C, Jung PP, Linster CL
  Title
Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase.
  Journal
J Biol Chem 291:6036-58 (2016)
DOI:10.1074/jbc.M115.704494
  Sequence
[sce:YEL071W]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.99.40
IUBMB Enzyme Nomenclature: 1.1.99.40
ExPASy - ENZYME nomenclature database: 1.1.99.40
BRENDA, the Enzyme Database: 1.1.99.40

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