Entry Name 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase;
Class Oxidoreductases;BRITE hierarchy
Sysname (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine:acceptor oxidoreductase
Reaction(IUBMB) (1) (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + acceptor = (3R)-3-hydroxy-16-methoxy-1,2-didehydro-2,3-dihydrotabersonine + reduced acceptor [RN:
R11777 ];
(2) (3R)-3-hydroxy-2,3-dihydrotabersonine + acceptor = (3R)-3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine + reduced acceptor [RN:
R11802 ]
Reaction(KEGG) Substrate (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine [CPD:
C04578 ];
acceptor [CPD:
C00028 ];
(3R)-3-hydroxy-2,3-dihydrotabersonine [CPD:
C21682 ]
Product (3R)-3-hydroxy-16-methoxy-1,2-didehydro-2,3-dihydrotabersonine [CPD:
C21678 ];
reduced acceptor [CPD:
C00030 ];
(3R)-3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine [CPD:
C21683 ]
Comment This enzyme is involved in the biosynthesis of vindoline and vindorosine in the plant Catharanthus roseus (Madagascar periwinkle). In vivo, it functions in the direction of reduction. It has no activity with 3-epoxylated compounds, which can form spontaneously from its unstable substrates.
History EC 1.1.99.41 created 2017
Pathway ec00901 Indole alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology K22323 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase
Reference Authors Qu Y, Easson ML, Froese J, Simionescu R, Hudlicky T, De Luca V
Title Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 1.1.99.41
