KEGG   ENZYME: 1.1.99.42
Entry
EC 1.1.99.42                Enzyme                                 
Name
4-pyridoxic acid dehydrogenase;
mlr6792 (locus name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
Sysname
4-pyridoxate:acceptor 5-oxidoreductase
Reaction(IUBMB)
4-pyridoxate + acceptor = 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + reduced acceptor [RN:R02993]
Reaction(KEGG)
R02993
Substrate
4-pyridoxate [CPD:C00847];
acceptor [CPD:C00028]
Product
5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate [CPD:C06050];
reduced acceptor [CPD:C00030]
Comment
The enzyme, characterized from the bacteria Pseudomonas sp. MA-1 and Mesorhizobium loti, participates in the degradation of pyridoxine (vitamin B6). It is membrane bound and contains FAD. The enzyme has been assayed in vitro in the presence of the artificial electron acceptor dichloroindophenol (DCPIP).
History
EC 1.1.99.42 created 2018
Pathway
ec00750  Vitamin B6 metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K18611  4-pyridoxate dehydrogenase
Genes
SLIG: GTU79_17840
PEN: PSEEN2583
PCAS: LOY40_17950
RPJ: N234_09610
CUH: BJN34_35770
BUR: Bcep18194_A4369
PPAI: E1956_29505 E1956_44070
PPNO: DA70_00425
PPNM: LV28_05890
PRB: X636_01905
PPUL: RO07_15700
PAPI: SG18_27430
PVE: UC34_08025
PFIB: PI93_020865
BAV: BAV1907(betA)
BHZ: ACR54_02254(alkJ_2)
BPDZ: BBN53_10555
AXO: NH44784_030571
ACHR: C2U31_22445
AAEG: RA224_08445
AMIM: MIM_c20980(betA3)
PIG: EGT29_03170
PACR: FXN63_10980
MLO: mlr6792
MLN: A9174_14040
MCI: Mesci_2016
MCIC: A4R28_16595
MAM: Mesau_02084
MESW: A9K65_010520
MESM: EJ066_21220
MESP: C1M53_04605
MHUA: MCHK_0414
MJR: EB229_14155
MERD: EB233_11005
MMEI: LRP31_23305
BARH: WN72_45755
LNE: FZC33_07130
RHZ: RHPLAN_10160 RHPLAN_17500 RHPLAN_55520
MEY: TM49_03780
MMED: Mame_00126(betA_1)
AUZ: Sa4125_23890
PSIN: CAK95_27150
NOH: G5V57_22515
RDI: CMV14_07050
SAMI: SAMIE_1031420
HTQ: FRZ44_12430
HADH: FRZ61_12490
TED: U5C87_03880
 » show all
Reference
1  [PMID:6348042]
  Authors
Yagi T, Kishore GM, Snell EE
  Title
The bacterial oxidation of vitamin B6. 4-Pyridoxic acid dehydrogenase: a membrane-bound enzyme from Pseudomonas MA-1.
  Journal
J Biol Chem 258:9419-25 (1983)
Reference
2  [PMID:18216065]
  Authors
Ge F, Yokochi N, Yoshikane Y, Ohnishi K, Yagi T
  Title
Gene identification and characterization of the pyridoxine degradative enzyme 4-pyridoxic acid dehydrogenase from the nitrogen-fixing symbiotic bacterium Mesorhizobium loti MAFF303099.
  Journal
J Biochem 143:603-9 (2008)
DOI:10.1093/jb/mvn010
  Sequence
[mlo:mlr6792]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.99.42
IUBMB Enzyme Nomenclature: 1.1.99.42
ExPASy - ENZYME nomenclature database: 1.1.99.42
BRENDA, the Enzyme Database: 1.1.99.42

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (548)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (51)   
   KEGG MGENES (496)   
Protein sequence (4)   
   UniProt (3)   
   SWISS-PROT (1)   
Protein domain (4)   
   InterPro (4)   
All databases (566)   

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