KEGG   ENZYME: 1.1.99.7
Entry
EC 1.1.99.7                 Enzyme                                 
Name
lactate---malate transhydrogenase;
malate-lactate transhydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
Sysname
(S)-lactate:oxaloacetate oxidoreductase
Reaction(IUBMB)
(S)-lactate + oxaloacetate = pyruvate + malate [RN:R01447]
Reaction(KEGG)
R01447
Substrate
(S)-lactate [CPD:C00186];
oxaloacetate [CPD:C00036]
Product
pyruvate [CPD:C00022];
malate [CPD:C00149]
Comment
Catalyses hydrogen transfer from C3 or C4 (S)-2-hydroxy acids to 2-oxo acids. It contains tightly bound nicotinamide nucleotide in its active centre. This cofactor cannot be removed without denaturation of the protein.
History
EC 1.1.99.7 created 1972
Pathway
ec00620  Pyruvate metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:4289051]
  Authors
Allen SH.
  Title
The isolation and characterization of malate-lactate transhydrogenase from Micrococcus lactilyticus.
  Journal
J Biol Chem 241:5266-75 (1966)
Reference
2  [PMID:4333516]
  Authors
Allen SH, Patil JR.
  Title
Studies on the structure and mechanism of action of the malate-lactate transhydrogenase.
  Journal
J Biol Chem 247:909-16 (1972)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.99.7
IUBMB Enzyme Nomenclature: 1.1.99.7
ExPASy - ENZYME nomenclature database: 1.1.99.7
BRENDA, the Enzyme Database: 1.1.99.7
CAS: 9077-15-0

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
All databases (10)   

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