KEGG ENZYME: 1.10.3.4

ENZYME: 1.10.3.4

Entry

EC 1.10.3.4                 Enzyme

Name

o-aminophenol oxidase;
isophenoxazine synthase;
o-aminophenol:O2 oxidoreductase;
2-aminophenol:O2 oxidoreductase

Class

Oxidoreductases;
Acting on diphenols and related substances as donors;
With oxygen as acceptor

Sysname

2-aminophenol:oxygen oxidoreductase

Reaction(IUBMB)

4 2-aminophenol + 3 O2 = 2 2-aminophenoxazin-3-one + 6 H2O [RN:R00074]

Reaction(KEGG)

R00074;
(other) R08762 R08763

Substrate

2-aminophenol [CPD:C01987];
O2 [CPD:C00007]

Product

2-aminophenoxazin-3-one [CPD:C02161];
H2O [CPD:C00001]

Comment

A flavoprotein which catalyses a 6-electron oxidation. The enzyme from the plant Tecoma stans requires Mn2+ and FAD [1] whereas the fungus Pycnoporus coccineus requires Mn2+ and riboflavin 5'-phosphate [2], the bacteria Streptomyces antibioticus requires Cu2+ [4] and the plant Bauhenia monandra does not require any co-factors [3].

History

EC 1.10.3.4 created 1972, modified 2006

Pathway

ec00380

Tryptophan metabolism

ec01100

Metabolic pathways

Orthology

K20204

grixazone synthase / o-aminophenol oxidase

K20219

o-aminophenol oxidase

Genes

GAM:	GII34_14885

SGR:	SGR_4246(griF) SGR_451

SANL:

KZO11_14645 KZO11_36460

SCYE:

R2B67_01230 R2B67_21105

SHY:

SHJG_7149

SHO:	SHJGH_6909

SMAL:

SMALA_8206

SSOI:

I1A49_44770

SALS:

SLNWT_0196

SCW:	TU94_26000

SCZ:	ABE83_01200

SCX:	AS200_11930

SCLF:

BB341_23440

SGS:	AVL59_11960

SCAD:

DN051_42725

SVU:	B1H20_33335

SLAU:

SLA_1218

SALF:

SMD44_06685(cotA)

SALJ:

SMD11_4561

SFK:

KY5_6301

SLK:	SLUN_21385

SCYA:

EJ357_36225

SKA:	CP970_09510

SRK:	FGW37_10820

SFY:	GFH48_03275

SBY:	H7H31_02485

SRIM:

CP984_27170

SPAC:

B1H29_00585

SCHA:

CP983_09795

SSPB:

CP982_31945

SBRO:

GQF42_32885

SCYG:

S1361_30405(phsA)

SROI:

IAG44_08720

SXN:	IAG42_07900

SHK:	J2N69_29590

STRY:

EQG64_33370

SDD:	D9753_07635

SMAO:

CAG99_16185 CAG99_20795

SAOV:

G3H79_07455

SDUR:

M4V62_10970

SLON:

LGI35_33140

SARG:

HKX69_07345

SJN:	RI060_08970

SOV:	QZH56_24575

SLAI:

P8A22_31355

SFP:	QUY26_08165

SINN:

ABB07_08015

STRZ:

OYE22_02440

KIT:	CFP65_6120

YIA:	LO772_07340

STRH:

GXP74_27850

AGLA:

OIE69_01240 OIE69_03860

MIO:	AOA12_11920

GMN:	GMOLON4_1400

KPL:	KPaMU14_03240

PBO:	PACID_21950

AACI:

ASQ49_10910

ACIJ:

JS278_01296(phsA)

SNAH:

OUQ99_09285

NGN:	LCN96_42575 LCN96_42620

AMD:	AMED_6380(cotA)

AMN:

RAM_32710

AMM:	AMES_6289(cotA)

AMZ:	B737_6289(cotA)

AMYC:

CU254_35240

AMYB:

BKN51_18515

AACD:

LWP59_01785

APRT:

MUY14_41215

ATHM:

L1857_04530

PAUT:

Pdca_55480(cotA)

SSYI:

EKG83_29820

KAL:

KALB_4813

KBU:	Q4V64_40400

KPHY:

AOZ06_18215

AHM:	TL08_10825 TL08_10830

ACTI:

UA75_11550 UA75_11555

ACAD:

UA74_11465 UA74_11470

AHG:	AHOG_10805(phsA1) AHOG_10810(phsA2)

SAQ:

Sare_1241

» show all

Reference

1 [PMID:14170322]

Authors

NAIR PM, VAIDYANATHAN CS.

Title

ISOPHENOXAZINE SYNTHASE.

Journal

Biochim Biophys Acta 81:507-16 (1964)
DOI:10.1016/0926-6569(64)90135-x

Reference

2 [PMID:14298835]

Authors

NAIR PM, VINING LC.

Title

ESOPHENOXAZINE SYNTHASE APOENZYME FROM PYCNOPORUS COCCINEUS.

Journal

Biochim Biophys Acta 96:318-27 (1965)
DOI:10.1016/0005-2787(65)90594-0

Reference

3 [PMID:4166439]

Authors

Subba Rao PV, Vaidyanathan CS.

Title

Studies on the metabolism of o-aminophenol. Purification and properties of isophenoxazine synthase from Bauhenia monandra.

Journal

Arch Biochem Biophys 118:388-94 (1967)
DOI:10.1016/0003-9861(67)90365-7

Reference

4 [PMID:2477054]

Authors

Barry CE 3rd, Nayar PG, Begley TP

Title

Phenoxazinone synthase: mechanism for the formation of the phenoxazinone chromophore of actinomycin.

Journal

Biochemistry 28:6323-33 (1989)
DOI:10.1021/bi00441a026

Sequence

[ag:AAA86668]

Other DBs

ExplorEnz - The Enzyme Database:

1.10.3.4

IUBMB Enzyme Nomenclature:

1.10.3.4

ExPASy - ENZYME nomenclature database:

1.10.3.4

BRENDA, the Enzyme Database:

1.10.3.4

CAS:

9013-85-8

DBGET integrated database retrieval system