KEGG   ENZYME: 1.11.1.11
Entry
EC 1.11.1.11                Enzyme                                 
Name
L-ascorbate peroxidase;
L-ascorbic acid peroxidase;
L-ascorbic acid-specific peroxidase;
ascorbate peroxidase;
ascorbic acid peroxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
Sysname
L-ascorbate:hydrogen-peroxide oxidoreductase
Reaction(IUBMB)
2 L-ascorbate + H2O2 + 2 H+ = L-ascorbate + L-dehydroascorbate + 2 H2O (overall reaction) [RN:R00644];
(1a) 2 L-ascorbate + H2O2 + 2 H+ = 2 monodehydroascorbate + 2 H2O [RN:R09540];
(1b) 2 monodehydroascorbate = L-ascorbate + L-dehydroascorbate (spontaneous) [RN:R03186]
Reaction(KEGG)
Substrate
L-ascorbate [CPD:C00072];
H2O2 [CPD:C00027];
H+ [CPD:C00080];
monodehydroascorbate [CPD:C01041]
Product
L-ascorbate [CPD:C00072];
L-dehydroascorbate [CPD:C05422];
H2O [CPD:C00001];
monodehydroascorbate [CPD:C01041]
Comment
A heme protein. Oxidizes ascorbate and low molecular weight aromatic substrates. The monodehydroascorbate radical produced is either directly reduced back to ascorbate by EC 1.6.5.4 [monodehydroascorbate reductase (NADH)] or undergoes non-enzymic disproportionation to ascorbate and dehydroascorbate.
History
EC 1.11.1.11 created 1983, modified 2010, modified 2011
Pathway
ec00053  Ascorbate and aldarate metabolism
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Orthology
K00434  L-ascorbate peroxidase
Genes
SHON118997631
AJM119035166
TCF131880205
HMG100213023
ATHAT1G07890(APX1) AT1G77490(TAPX) AT3G09640(APX2) AT4G08390(SAPX) AT4G32320(APX6) AT4G35000(APX3) AT4G35970(APX5)
ALY9303117 9303168 9305354 9310603 9318697 9322135 9322136 9325208 9328486
CRB17878438 17879152 17880619 17884052 17890815 17893627 17893747 17896270 17899405
CSAT104702532 104707160 104713416 104716524 104716637 104716949 104720283 104721287 104729589 104729717 104730042 104736879 104739373 104745137 104747469 104747470 104751645 104754395 104754965 104764660 104765991 104766972 104766975 104792024 104792033
EUSEUTSA_v10008402mg EUTSA_v10018581mg EUTSA_v10021381mg EUTSA_v10022797mg EUTSA_v10023023mg EUTSA_v10025686mg EUTSA_v10025911mg EUTSA_v10025942mg EUTSA_v10028759mg
BRP103832195 103836413 103838791 103843426 103848043 103860476 103862119 103862385 103871533 103871729
BNA106346376 106347996 106354606 106362267 106389449 106400462 106401842 106407140 106415142 106419633 106420215 106422138 106423276 106427935 106428784 106439834 106446154 106446926 111199406 111207743 125580535
BOE106294764 106300129 106303893 106306187 106307224 106308404 106312994 106324757 106324893 106328411
RSZ108812703 108814310 108814761 108814785 108820821 108822828 108824179 108837581 108848897 108851335 108851337 108856542 108856708 130494473 130508251
THJ104800618 104803658 104804273 104804329 104813151 104813669 104815756 104816316 104826354
CPAP110806432 110808580 110813572 110822345 110825509
CIT102607382 102610460 102622372 102623082 102629716 102630188
CICCICLE_v10001194mg CICLE_v10008868mg CICLE_v10012554mg CICLE_v10026205mg CICLE_v10028990mg CICLE_v10030198mg
PVY116124157 116126833 116129839 116129862 116131607 116138091 116145613
MINC123194353 123198607 123200457 123201325 123203234 123206824 123207163 123209556 123212144 123214773 123224991 123228152 123229226
TCC18587790 18590832(APX) 18592363 18597892 18607557 18610739
GRA105767858 105769825 105769872 105772729 105773990 105781150 105785908 105787462 105792368 105792370 105792371 105795404
GHI107898310 107900057 107901425 107906191 107908653 107909465 107916997 107922467 107924317 107927982 107936563 107938996 107942909 107952958 107959060 107961677 107962527 107962799 107962802 107962803 121212696 121229506
GAB108453402 108453752 108463433 108467585 108467715 108470238 108475956 108484599 108486104 108488538 108489681
HSYR120131431 120139822 120141606 120145805 120148287 120154056 120177897 120180125 120184814 120192198 120193889 120196143 120215348 120216192
DZI111281977 111285965 111296490 111297878 111300438 111302517 111303578 111308750 111312285 111315649 111317254 111317709
EGR104418937 104421699 104432832 104435850 104437032 104439814 104450927
GMX100170727 100170737 100784258 100792735 100799504 100802238 100806101 100813526 112998405 553156(APX1) 606508(APX2)
GSJ114373310 114374032 114374988 114375739 114379910 114380179 114410407 114411121 114414979 114415422 114419669
PVUPHAVU_002G104700g PHAVU_002G107000g PHAVU_009G093000g PHAVU_009G1265000 PHAVU_011G035000g PHAVU_011G071300g
VRA106756337 106756347 106759908 106762832 106776684 106776989
VAR108321266 108321268 108330815 108331841 108340597 108340692
VUN114162470 114164188 114169494 114169897 114173407
VUM124823125 124835734 124838303 124840963 124848319 124848328 124849005
CCAJ109798454 109798834 109800264 109800265 109800266 109800688 109808156 109817680
APRC113859214 113864980 113866037 113866932 113868726
MTR11412115 11414804 11419719 11436614 11443228
TPRA123894314 123908210 123908394 123913074 123919810
CAM101496561 101497640 101497868(peroxidase) 101507560 101511999(peroxidase)
PSAT127082822 127087660 127105270 127107321 127120134
VVO131601933 131601943 131602163 131631310 131631311 131655115 131655123 131661421
LJALj1g3v0839140.1(Lj1g3v0839140.1) Lj1g3v0839140.2(Lj1g3v0839140.2) Lj1g3v1901620.1(Lj1g3v1901620.1) Lj3g3v3465510.1(Lj3g3v3465510.1)
ADU107457615 107460700 107461634 107463271 107476561 107476911 107487471
AIP107606045 107611695 107612004 107628775 107629166 107641638
AHF112706052 112707898 112708373 112736565 112737011 112747725 112764605 112771587 112772858 112786625 112789081 112800332
LANG109325078 109328226 109328584 109332963 109343738 109344314 109348741 109351626 109353210 109355353 109355503 109363606
PCIN129284514 129285750 129294157 129297888 129303315 129315810 129317285 129321941
QSAO6P43_000279 O6P43_002117 O6P43_010337 O6P43_011462 O6P43_015163 O6P43_015696 O6P43_019769 O6P43_028320 O6P43_033593
FVE101294792 101295782 101296044 101298335 101306607 101311062 101312209
RCN112167733 112172770 112172888 112173456 112183427 112183428 112193157
PPER109950245 18768608 18769065 18772001 18774632 18788446 18788761
PMUM103319703 103319803 103324634 103334818 103337744 103340411 103340413
PAVI110744516 110750580 110752748 110753793 110758673 110758720 110763755
PDUL117613978 117614320 117629757 117630724 117636035 117636036 117637594
MDM103407746 103410608 103412451 103413542 103413735 103415927 103415928 103428850 103441493 103447832 103456150 103456198
MSYL126589851 126594449 126603873 126604926 126604927 126613863 126615748 126617694 126623325 126632506
PXB103929005 103929006 103934327 103939335 103943785 103946703 103948906 103953464 103953465 103965570 103965571 103965607 103965616 103967787
ZJU107404477 107405610 107411283 107421180 107424422 107432898 132803817
MNT21385400 21387990 21394468 21396537 21407196 21407716 21409300 21409302 21409303
CSAV115702667 115702668 115704704 115706904 115707840 115709468 115711955 115719381
CSV101203032 101206941 101216396 101216755 101220337 101221563
CMO103485146 103488313 103490293 103497220 103501901 103504072
BHJ120072693 120075834 120076694 120078025 120083781 120087817
MCHA111004683 111005573 111007684 111011899 111015531 111025487
CMAX111468480 111469373 111478732 111481050 111484522 111486242 111487023 111489480 111492742 111496267 111499924
CMOS111435312 111445585 111445914 111448698 111451461 111452295 111453891 111454238 111455146 111458967 111464664
CPEP111776845 111782837 111787438 111788220 111792489 111794479 111799327 111804443 111808383 111811124 111811568
RCU8259449 8260651 8261021 8263921 8277776 8283829
JCU105637635 105638985 105642164 105647126
HBR110633839 110634700 110641765 110649030 110652554 110652862 110657885 110663897
MESC110603739 110606172 110606939 110606978 110613836 110618929 110621319 110626416 110627151
POP18099176 18100237 7453643 7460959 7463149 7467602 7471595 7491126 7494249
PEU105107245 105110717 105114120 105127784 105136153 105138704 105140948 105141227 105142465
PALZ118029249 118029860 118034724 118040460 118045884 118048545 118050275 118056899 118058813
JRE108981203 108982181 108989652 108992224 108993393 109006594 109017737 109020260
CILL122277817 122292426 122296386 122313335 122317412 122318915
CAVE132162398 132163322 132163374 132171709 132184096 132187864 132188992 132191806 132191918
QSU111986906 111986907 112020834 112028339 112034268 112035433 112037058
QLO115953030 115960304 115968592 115974948 115988749 115994468
TWL119979903 119989178 119993665 119996455 119997328 120002798 120013531 120015397
VVI100233013 100233048(APX) 100246866 100247405 100254009 104879121
VRI117906785 117911064 117912265 117913691 117916461 117919656
SLY101257790 101258987 101262528(APX7) 101264261 101264282 101264583 778223(APX1) 778224(APX2) 778341(APX6)
SPEN107005028 107007774 107008867 107009391 107023536 107023623 107023881 107029071 107029646 107029648
SOT102578720 102579602 102586145(APX) 102586473(APx) 102591426 102595667 102597356(APX) 102597359 102597684
SSTN125845069 125849001 125849502 125867429 125871593 125872555 125874359 125874399 125878176
SDUL129874749 129875023 129885322 129889136 129899031 129899346 129899501 129902454
CANN107838875 107840564 107842932 107859857 107859858 107868078 107873001 107873422 107873435
LBB132599323 132605926 132605927 132623401 132623673 132623929 132624641 132627000 132630110 132636205 132641433
NTA107759348 107759703 107763284 107765289(APX) 107774730 107775122 107776943 107779974 107782353 107782355 107783195 107783197 107787273 107791412 107792162 107809385 107819788
NSY104216288 104221831 104232845 104233186 104234451 104243324 104243325 104244992 104249656
NTO104093447 104101322 104105876 104105877 104110367 104112174 104112377 104119562
NAU109208242 109208522 109208525 109208571 109209066 109215800 109229383 109238727
INI109156366 109163296 109163297 109165070 109169557 109177383 109177732 109192924
ITR116000189 116002721 116006215 116017364 116024878 116024879 116032398
SIND105155173 105155321 105159461 105164521 105169784 105170682 105174346
OEU111369609 111372265 111374886 111387515 111393231 111399815 111403155 111410119
EGT105949203 105957766 105959157 105974328 105977246
SSPL121742289 121745414 121748480 121750417 121752419 121764629 121779838 121782989 121785033 121786877 121795610
SMIL130989314 130997661 131000004 131000707 131011869 131015543 131020103 131023823
APAN127246642 127252248 127257077 127257167 127259800 127262126 127265435
HAN110871293 110898546 110911573 110911973 110918963 110926092 110939906 110941205
ECAD122590766 122602698 122607341 122609751 122610025 122611228
LSV111882573 111883147 111884264 111895628 111897078 111897079 111897082 111897699 111899201 111902014 111909485 111915410 111915448 111915449
CCAV112508077 112512067 112514070 112517937 112521260 112524471 112527989
DCR108192373 108205033 108205636 108205654 108205727 108214806 108215779 108217695 108221051
CSIN114265311 114279703 114284060 114285269 114289093 114298111 114311391
RVL131302567 131314827 131318785 131323291 131324643 131326293 131329120 131332049
AEW130755544 130759158 130761389 130765063 130769979 130774563 130776361 130781750 130790637 130794021
BVG104891011 104895166 104895169 104895170 104895172 104895312 104895313 104903122 104903932 104904642 104908745 104908898
SOE110778432 110786989 110788379 110790239 110790627 110790631 110797270 110802362 110802381
CQI110694728 110694729 110694783 110695745 110698631 110701606 110701628 110701631 110701632 110705037 110709763 110711843 110718539 110721056 110724440 110724531 110724607 110733589 110739342
ATRI130798854 130804266 130805515 130806020 130810251 130812706 130824240 130824241 130824242
MOF131148126 131152101 131155806 131156655 131161961 131167932
NNU104587545 104592451 104594740 104603616 104605785
MING122057883 122063806 122071585 122075921 122085172 122087413 122090469
TSS122648216 122648778 122652897 122653276 122658417 122668032 122669521
PSOM113282817 113288942 113290889 113309651 113321825 113330609 113346337 113356406 113357184 113361130
OSA4329643 4332474 4335202 4335896 4344397 4346078 4346247 4351663 4351664 9269342
DOSAOs02t0553200-01(Os02g0553200) Os03t0285700-01(Os03g0285700) Os04t0223300-00(Os04g0223300) Os04t0434800-01(Os04g0434800) Os07t0694700-01(Os07g0694700) Os08t0522400-01(Os08g0522400) Os08t0549100-01(Os08g0549100) Os12t0178100-01(Os12g0178100) Os12t0178200-01(Os12g0178200)
OBR102702265 102702954 102703203 102713566 102713598 102714726 102719916
OGL127756834 127756835 127764204 127767452 127771151 127771241 127779602 127782355 127782475 127783618
BDI100825789 100826086 100828614 100836915 100836984 100838031 100838967 100839539
ATS109739529 109747802 109748346 109749043 109757934 109771362 109785628 109786189
TDC119285357 119290733 119300763 119308144 119318682 119325534 119328631 119336473 119348043 119353103 119355195 119358815 119362135 119362185 119364322
TAES123043447 123043501 123045501 123048498 123051366 123053349 123085536 123092501 123097814 123102836 123111065 123120058 123130688 123140069 123146328 123151359 123152520 123156422 123164630 123165359 123176406 123184518 123187311 123189249 123189250 542880
TUA125508522 125515615 125519646 125530284 125535467 125538321 125552029
LPER127295873 127299666 127316421 127331163 127331326 127334512 127334889
LRD124652386 124654893 124661425 124673359 124673772 124673860 124674121 124675475 124681785 124692377 124692381 124696499 124702148
SBI8058035 8064261 8067730 8076303 8077530 8080310 8081349 8081447
ZMA100193740 100193965 100194161 100282326 100283135 100285887 103634173 103634427 103639279 542476
SITA101753441 101754668 101760004 101761338 101769679 101776821 101780973 101786781
SVS117837486 117842945 117859935 117860239 117863384 117865913 117865975
PVIR120640175 120640948 120641028 120652750 120662269 120663742 120678459 120678528 120682240 120682370 120683430 120687989 120696865 120712855 120713778
PHAI112873832 112880254 112884946 112890455 112896534 112896981 112899872 112901091
PDA103701344 103702852 103706176 103706644 103708739 103709007 103719946 103720470
EGU105033983 105034165 105038429 105044047 105044666 105045793 105046775 105051809 105055090
MUS103968393 103969335 103971212 103984165(APX) 103985795 103989062 103989729 103991735 103992108
ZOF121968459 121971860 121976899 121982423 121986318 121988513 121988808 121988809 121997389 122001029 122005309 122007419 122008331 122014382 122019986 122021044 122024395 122051428 122052343
DCT110094846 110097560 110101121 110102819 110107707
PEQ110019994 110022020 110024096 110031920 110034160 110035128
AOF109823240 109830309 109845098 109848456 109850069 109851292
MSIN131223134 131229519 131236620 131239642 131251334 131253258
NCOL116245954 116248806 116254643 116255429 116255882 116260421 116266532
ATR18423687 18431875 18436903 18446589
SMOSELMODRAFT_108251 SELMODRAFT_119039 SELMODRAFT_131845 SELMODRAFT_139337 SELMODRAFT_144791 SELMODRAFT_156990 SELMODRAFT_157825 SELMODRAFT_169019 SELMODRAFT_270176 SELMODRAFT_271672 SELMODRAFT_74674 SELMODRAFT_85469 SELMODRAFT_92054 SELMODRAFT_94117
PPP112273052 112273380 112273527 112285230 112294750
CRECHLRE_02g087700v5 CHLRE_05g233900v5 CHLRE_06g285150v5
VCNVOLCADRAFT_62034(apx2) VOLCADRAFT_82395(apx1)
MNGMNEG_1131 MNEG_3533
CSLCOCSUDRAFT_19106 COCSUDRAFT_20424 COCSUDRAFT_26227 COCSUDRAFT_49139 COCSUDRAFT_58469
CVRCHLNCDRAFT_19036 CHLNCDRAFT_28686
APROF751_6473
OLUOSTLU_32890 OSTLU_6186 OSTLU_93205
OTAOT_ostta01g03640 OT_ostta08g00190 OT_ostta09g00500
BPGBathy04g00180 Bathy10g03910
MISMICPUN_109237 MICPUN_51963 MICPUN_70664
MPPMICPUCDRAFT_48214(JGI:MicpuC2_48214) MICPUCDRAFT_56164(JGI:MicpuC2_56164) MICPUCDRAFT_8305(JGI:MicpuC2_8305)
CMECYME_CMM158C
GSLGasu_32860 Gasu_33520
CCPCHC_T00008640001 CHC_T00010024001
PPEIPpBr36_04871
PGRIPgNI_11278
GLZGLAREA_10389
MPRMPER_08989
MBRMONBRDRAFT_13407 MONBRDRAFT_18816
SREPTSG_00062
SMINv1.2.006460.t2(symbB.v1.2.006460.t2) v1.2.015684.t1(symbB.v1.2.015684.t1) v1.2.018236.t1(symbB.v1.2.018236.t1) v1.2.018679.t1(symbB.v1.2.018679.t1) v1.2.024207.t2(symbB.v1.2.024207.t2) v1.2.024207.t3(symbB.v1.2.024207.t3) v1.2.028328.t1(symbB.v1.2.028328.t1) v1.2.032093.t1(symbB.v1.2.032093.t1)
PTIPHATRDRAFT_13174 PHATRDRAFT_46616 PHATRDRAFT_47395
FCYFRACYDRAFT_173923(APX1) FRACYDRAFT_287495(APX3)
TPSTHAPSDRAFT_262753(ApxS) THAPSDRAFT_262809 THAPSDRAFT_38724
GTTGUITHDRAFT_153788 GUITHDRAFT_65752
TCR503745.30 506193.60
LMALMJF_34_0070(APX)
LIFLINJ_34_0070(APX)
LDOLDBPK_340070
LMILMXM_33_0070
LBZLBRM_20_0150(APX)
LPANLPMP_200320(APX)
 » show all
Reference
1  [PMID:6772104]
  Authors
Shigeoka S, Nakano Y, Kitaoka S.
  Title
Purification and some properties of L-ascorbic-acid-specific peroxidase in Euglena gracilis Z.
  Journal
Arch Biochem Biophys 201:121-7 (1980)
DOI:10.1016/0003-9861(80)90495-6
Reference
2  [PMID:6768357]
  Authors
Shigeoka S, Nakano Y, Kitaoka S.
  Title
Metabolism of hydrogen peroxide in Euglena gracilis Z by L-ascorbic acid peroxidase.
  Journal
Biochem J 186:377-80 (1980)
DOI:10.1042/bj1860377
Reference
3
  Authors
Nakano, Y and Asada, K.
  Title
Purification of ascorbate peroxidase in spinach chloroplasts; its inactivation in ascorbate-depleted medium and reactivation by monodehydroascorbate radical.
  Journal
Plant Cell Physiol 28:131-140 (1987)
Reference
4  [PMID:7703247]
  Authors
Patterson WR, Poulos TL
  Title
Crystal structure of recombinant pea cytosolic ascorbate peroxidase.
  Journal
Biochemistry 34:4331-41 (1995)
DOI:10.1021/bi00013a023
Reference
5  [PMID:15236572]
  Authors
Sharp KH, Moody PC, Brown KA, Raven EL
  Title
Crystal structure of the ascorbate peroxidase-salicylhydroxamic acid complex.
  Journal
Biochemistry 43:8644-51 (2004)
DOI:10.1021/bi049343q
  Sequence
[gmx:553156]
Reference
6  [PMID:16784232]
  Authors
Macdonald IK, Badyal SK, Ghamsari L, Moody PC, Raven EL
  Title
Interaction of ascorbate peroxidase with substrates: a mechanistic and structural analysis.
  Journal
Biochemistry 45:7808-17 (2006)
DOI:10.1021/bi0606849
  Sequence
[gmx:553156]
Other DBs
ExplorEnz - The Enzyme Database: 1.11.1.11
IUBMB Enzyme Nomenclature: 1.11.1.11
ExPASy - ENZYME nomenclature database: 1.11.1.11
BRENDA, the Enzyme Database: 1.11.1.11
CAS: 72906-87-7

DBGET integrated database retrieval system