KEGG   ENZYME: 1.11.1.22
Entry
EC 1.11.1.22                Enzyme                                 
Name
hydroperoxy fatty acid reductase;
slr1171 (gene name);
slr1992 (gene name);
hydroperoxy fatty acid:NADPH oxidoreductase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
Sysname
NADPH:hydroperoxy fatty acid oxidoreductase
Reaction(IUBMB)
a hydroperoxy fatty acid + NADPH + H+ = a hydroxy fatty acid + NADP+ + H2O
Substrate
hydroperoxy fatty acid;
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
hydroxy fatty acid;
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the cyanobacterium Synechocystis PCC 6803, can reduce unsaturated fatty acid hydroperoxides and alkyl hydroperoxides. The enzyme, which utilizes NADPH generated by the photosynthetic electron transfer system, protects the cells from lipid peroxidation.
History
EC 1.11.1.22 created 2013
Orthology
K20207  hydroperoxy fatty acid reductase
Genes
VOG: LCH97_16840
SYN: slr1171 slr1992
SYZ: MYO_113170 MYO_117870
SYY: SYNGTS_1305(slr1992) SYNGTS_1769(slr1171)
SYT: SYNGTI_1305(slr1992) SYNGTI_1769(slr1171)
SYS: SYNPCCN_1304(slr1992) SYNPCCN_1768(slr1171)
SYQ: SYNPCCP_1304(slr1992) SYNPCCP_1768(slr1171)
SYJ: D082_12190(gpx1) D082_14430(gpx2)
SYO: C7I86_06760
WNA: KA717_05995
SYP: SYNPCC7002_A0970
SYV: AWQ23_05015
SYL: AWQ21_04785
LEP: Lepto7376_4561
SYNN: NIES970_13410
SBAM: SCB77_05900
NKF: Nkreftii_002768
 » show all
Reference
1  [PMID:11418106]
  Authors
Gaber A, Tamoi M, Takeda T, Nakano Y, Shigeoka S
  Title
NADPH-dependent glutathione peroxidase-like proteins (Gpx-1, Gpx-2) reduce unsaturated fatty acid hydroperoxides in Synechocystis PCC 6803.
  Journal
FEBS Lett 499:32-6 (2001)
DOI:10.1016/S0014-5793(01)02517-0
  Sequence
[syn:slr1171 slr1992]
Reference
2  [PMID:15347790]
  Authors
Gaber A, Yoshimura K, Tamoi M, Takeda T, Nakano Y, Shigeoka S
  Title
Induction and functional analysis of two reduced nicotinamide adenine dinucleotide phosphate-dependent glutathione peroxidase-like proteins in Synechocystis PCC 6803 during the progression of oxidative stress.
  Journal
Plant Physiol 136:2855-61 (2004)
DOI:10.1104/pp.104.044842
  Sequence
[syn:slr1171 slr1992]
Other DBs
ExplorEnz - The Enzyme Database: 1.11.1.22
IUBMB Enzyme Nomenclature: 1.11.1.22
ExPASy - ENZYME nomenclature database: 1.11.1.22
BRENDA, the Enzyme Database: 1.11.1.22

  All links  
Gene (25)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (24)   
Protein sequence (50)   
   UniProt (48)   
   SWISS-PROT (2)   
DNA sequence (970)   
   GenBank (493)   
   EMBL (477)   
Protein domain (5)   
   InterPro (5)   
All databases (1050)   

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