KEGG   ENZYME: 1.12.2.1
Entry
EC 1.12.2.1                 Enzyme                                 
Name
cytochrome-c3 hydrogenase;
H2:ferricytochrome c3 oxidoreductase;
cytochrome c3 reductase;
cytochrome hydrogenase;
hydrogenase [ambiguous]
Class
Oxidoreductases;
Acting on hydrogen as donor;
With a cytochrome as acceptor
Sysname
hydrogen:ferricytochrome-c3 oxidoreductase
Reaction(IUBMB)
H2 + 2 ferricytochrome c3 = 2 H+ + 2 ferrocytochrome c3 [RN:R04015]
Reaction(KEGG)
R04015
Substrate
H2 [CPD:C00282];
ferricytochrome c3 [CPD:C02682]
Product
H+ [CPD:C00080];
ferrocytochrome c3 [CPD:C02684]
Comment
An iron-sulfur protein. Some forms of the enzyme contain nickel ([NiFe]-hydrogenases) and, of these, some contain selenocysteine ([NiFeSe]-hydrogenases). Methylene blue and other acceptors can also be reduced.
History
EC 1.12.2.1 created 1972, modified 2002
Orthology
K00437  [NiFe] hydrogenase large subunit
K18008  [NiFe] hydrogenase small subunit
Genes
HTMRZR91_08890
HMRHipma_1098
GURGura_0544
DDSDdes_1038 Ddes_1039
DFIAXF13_05345 AXF13_05350
DPGDESPIGER_2408 DESPIGER_2409
DEFCNY67_06350 CNY67_06355
DTRRSDT_0750(hynA) RSDT_0751(hynB)
DFLDFE_1090 DFE_1091
PSYFN1030_05840 N1030_05845
DSBLN040_03705 LN040_03710 LN040_10885 LN040_10890
DMADMR_15600 DMR_15610
DCBC3Y92_13765 C3Y92_13770
DGGDGI_2261(hydB) DGI_2262(hydA)
DDEDde_2137 Dde_2138 Dde_3755 Dde_3756
DMSE8L03_04605 E8L03_04610
DSADesal_1915 Desal_1916
DHYDESAM_22353(hybC) DESAM_22354(hydA)
DAFDesaf_3127 Desaf_3128
DASDaes_2582 Daes_2583
DPIBN4_11411(hynB-1) BN4_11412(hynA-1) BN4_12036(hynA) BN4_12037(hynB)
DEJAWY79_10910 AWY79_10915 AWY79_15475 AWY79_15480
PPRFDPRO_2872(hydA) DPRO_2873(hybC) DPRO_3463(hydB) DPRO_3464(hynB)
PSELGM415_00940 GM415_00945
DDNDND132_3240 DND132_3241
PSEFPSDVSF_33320(hynB1) PSDVSF_33330(hynA-1)
PPORJCM14722_26830(hynB1) JCM14722_26840(hynA-1)
PNWSYK_14410(hynA-1_1) SYK_32520(hynB1) SYK_32530(hynA-1_2)
PTHELF599_05010 LF599_05015
DSXGD604_03825 GD604_03830
DSDGD606_11990 GD606_18650 GD606_18655
PBIZLWC08_05010 LWC08_05015
DVUDVU_1921(hynB-1) DVU_1922(hynA-1) DVU_2525(hynB-2) DVU_2526(hynA-2)
DVLDvul_0718 Dvul_0719 Dvul_1245 Dvul_1246
DVMDvMF_0270 DvMF_0271 DvMF_1732 DvMF_1733
DVGDeval_1388 Deval_1389 Deval_2330 Deval_2331
CLIHKPS_000369 KPS_000370 KPS_001976 KPS_001977
TMURJBF11_08395 JBF11_08400
DBADbac_0766 Dbac_0767
DESUNLA06_03975 NLA06_03980
THEWTDMWS_05530(hynB1) TDMWS_05540(hynA-1)
DRTDret_0265(hydB) Dret_0266(hydA)
DSFUWK_01156
DALDalk_2275 Dalk_2276
DATHRM2_22350(hynB) HRM2_22360(hynA)
DWDDSCW_35860(hynA-1) DSCW_35870(hynB1)
DALKDSCA_34960(hynA-1) DSCA_34970(hynB1_1) DSCA_49780 DSCA_49790(hynB1_2)
DLIdnl_48300(hynA) dnl_48320(hynB)
DTIDesti_3745 Desti_3746
SFUSfum_2952 Sfum_2953
DAXFDQ92_06195 FDQ92_06200
DBRDeba_1400 Deba_1401
TOPTOPB45_0886
OCWOW730_19290
AHATADCFC_11360(hynA-1)
RTSCE91St31_14000(hynA-1)
EBZJ7S26_02745
 » show all
Reference
1  [PMID:4364940]
  Authors
Der Vartanian DV, LeGall J.
  Title
A monomolecular electron transfer chain: structure and function of cytochrome C3.
  Journal
Biochim Biophys Acta 346:79-99 (1974)
DOI:10.1016/0304-4173(74)90012-3
Reference
2  [PMID:3546297]
  Authors
Higuchi Y, Yasuoka N, Kakudo M, Katsube Y, Yagi T, Inokuchi H.
  Title
Single crystals of hydrogenase from Desulfovibrio vulgaris Miyazaki F.
  Journal
J Biol Chem 262:2823-5 (1987)
  Sequence
Reference
3  [PMID:13741672]
  Authors
RIKLIS E, RITTENBERG D.
  Title
Some observations on the enzyme, hydrogenase.
  Journal
J Biol Chem 236:2526-9 (1961)
Reference
4  [PMID:13745271]
  Authors
SADANA JC, MOREY AV.
  Title
Purification and properties of the hydrogenase of Desulfovibrio desulfuricans.
  Journal
Biochim Biophys Acta 50:153-63 (1961)
DOI:10.1016/0006-3002(61)91072-1
Reference
5  [PMID:7854413]
  Authors
Volbeda A, Charon MH, Piras C, Hatchikian EC, Frey M, Fontecilla-Camps JC.
  Title
Crystal structure of the nickel-iron hydrogenase from Desulfovibrio gigas.
  Journal
Nature 373:580-7 (1995)
DOI:10.1038/373580a0
  Sequence
Reference
6  [PMID:10378275]
  Authors
Garcin E, Vernede X, Hatchikian EC, Volbeda A, Frey M, Fontecilla-Camps JC.
  Title
The crystal structure of a reduced [NiFeSe] hydrogenase provides an image of the activated catalytic center.
  Journal
Structure 7:557-66 (1999)
DOI:10.1016/S0969-2126(99)80072-0
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.12.2.1
IUBMB Enzyme Nomenclature: 1.12.2.1
ExPASy - ENZYME nomenclature database: 1.12.2.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.12.2.1
BRENDA, the Enzyme Database: 1.12.2.1
CAS: 9027-05-8

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