KEGG   ENZYME: 1.12.5.1
Entry
EC 1.12.5.1                 Enzyme                                 
Name
hydrogen:quinone oxidoreductase;
hydrogen-ubiquinone oxidoreductase;
hydrogen:menaquinone oxidoreductase;
membrane-bound hydrogenase;
quinone-reactive Ni/Fe-hydrogenase
Class
Oxidoreductases;
Acting on hydrogen as donor;
With a quinone or similar compound as acceptor
Sysname
hydrogen:quinone oxidoreductase
Reaction(IUBMB)
H2 + menaquinone = menaquinol [RN:R02965]
Reaction(KEGG)
R02965
Substrate
H2 [CPD:C00282];
menaquinone [CPD:C00828]
Product
menaquinol [CPD:C05819]
Comment
Contains nickel, iron-sulfur clusters and cytochrome b. Also catalyses the reduction of water-soluble quinones (e.g. 2,3-dimethylnaphthoquinone) or viologen dyes (benzyl viologen or methyl viologen).
History
EC 1.12.5.1 created 1999 as EC 1.12.99.3, transferred 2002 to EC 1.12.5.1
Orthology
K05922  quinone-reactive Ni/Fe-hydrogenase large subunit
K05927  quinone-reactive Ni/Fe-hydrogenase small subunit
Genes
PDSCAY62_05940 CAY62_05945
SONSO_2098(hyaB) SO_2099(hyaA)
SFRSfri_2103 Sfri_2104
SAZSama_1678 Sama_1679
SBLSbal_1888 Sbal_1889
SBMShew185_1914 Shew185_1915
SBNSbal195_1921 Sbal195_1922
SBPSbal223_2404 Sbal223_2405
SBTSbal678_1960 Sbal678_1961
SBSSbal117_2006 Sbal117_2007
SBBSbal175_2465 Sbal175_2466
SLOShew_1764 Shew_1765
SPCSputcn32_2088 Sputcn32_2089
SHPSput200_1921 Sput200_1922
SSESsed_1907 Ssed_1908
SPLSpea_2032 Spea_2033
SHEShewmr4_1821 Shewmr4_1822
SHMShewmr7_2155 Shewmr7_2156
SHNShewana3_1879 Shewana3_1880
SHWSputw3181_1923 Sputw3181_1924
SHLShal_2261 Shal_2262
SWPswp_2639 swp_2640
SHFCEQ32_05685 CEQ32_05690
SJASJ2017_2000 SJ2017_2001
SBJCF168_11330 CF168_11335
SMAVCFF01_10565 CFF01_10570
SHEWCKQ84_18175 CKQ84_18180
SALGBS332_18620 BS332_18625
SLJEGC82_10660 EGC82_10665
SMAIEXU30_08260
SPOLFH971_09430 FH971_09435
SKHSTH12_01355(hydB) STH12_01356(hydA)
SAESHBH39_13550 HBH39_13555
SLITJQC75_08375 JQC75_08380
SDKKHX94_17960(hyaB) KHX94_17965(hyaA) KHX94_17975 KHX94_17980(hyaA)
SCAATUM17387_21020(hyaA) TUM17387_21030(hyaB)
SEURFM038_010610(hyaB) FM038_010615(hyaA)
SYKKDN34_08530 KDN34_08535 KDN34_08545 KDN34_08550
SCYPJYB88_09280 JYB88_09285
SAVIJYB87_09490 JYB87_09495 JYB87_09505 JYB87_09510
SSEMJYB85_09495 JYB85_09500
SGLAFJ709_09540 FJ709_09545
SINVK8B83_12375(hyaB) K8B83_12380(hyaA)
SXMMKD32_09155(hyaB) MKD32_09160(hyaA)
SVMKDH10_001071 KDH10_001072
SHEJMZ182_10460(hyaA) MZ182_10465(hyaB)
SSEHN7V09_13985(hyaA) N7V09_13990(hyaB)
SCHKGII14_10580 GII14_10585
SACHK0H61_07930(hyaB) K0H61_07935(hyaA)
SAEGK0H80_08940(hyaB) K0H80_08945(hyaA)
SDEOD0436_11285(hyaA) D0436_11290(hyaB)
SMESK0I73_08180(hyaB) K0I73_08185(hyaA)
SHAOK0H81_10970(hyaA) K0H81_10975(hyaB)
SZHK0H63_09045(hyaB) K0H63_09050(hyaA)
SSPAK0I31_09090(hyaB) K0I31_09095(hyaA)
SHNSK0J45_08905(hyaB) K0J45_08910(hyaA)
SRHSK0I63_09035(hyaB) K0I63_09040(hyaA)
SPSJK0I62_08665(hyaB) K0I62_08670(hyaA)
SMAYK0H60_09515(hyaB) K0H60_09520(hyaA)
SOGRA178_12800(hyaA) RA178_12805(hyaB)
SPSREGC80_15510 EGC80_15515
FBLFbal_1090 Fbal_1091 Fbal_3143 Fbal_3144
FESHER31_05840 HER31_05845
TCXTcr_2037 Tcr_2038
TMHJX580_00945
HPYHP_0631 HP_0632
HEOC694_03265 C694_03270
HPJjhp_0574(hyaA) jhp_0575(hyaB)
HPAHPAG1_0614 HPAG1_0615
HPSHPSH_03705 HPSH_03710
HHPHPSH112_03855 HPSH112_03860
HHQHPSH169_03245 HPSH169_03250
HHRHPSH417_03055 HPSH417_03060
HPGHPG27_592(hydA) HPG27_593(hydB)
HPPHPP12_0643(hydA) HPP12_0644(hydB)
HPBHELPY_0739(hydB) HELPY_0740(hydA)
HPLHPB8_831(hydA) HPB8_832(hydB)
HPCHPPC_03185 HPPC_03190
HCAHPPC18_03040 HPPC18_03045
HPMHPSJM_03205 HPSJM_03210
HPEHPELS_03385 HPELS_03390
HPOHMPREF4655_20967(hydB) HMPREF4655_20968
HPIhp908_0642 hp908_0643
HPQhp2017_0619 hp2017_0620
HPWhp2018_0620 hp2018_0621
HPUHPCU_03435 HPCU_03440
HEFHPF16_0728(hyaB) HPF16_0729(hyaA)
HPFHPF30_0695(hyaB) HPF30_0696(hyaA)
HEQHPF32_0608(hyaA) HPF32_0609(hyaB)
HEXHPF57_0655(hyaA) HPF57_0656(hyaB)
HPTHPSAT_03630 HPSAT_03635
HPZHPKB_0711(hyaB) HPKB_0712(hyaA)
HPVHPV225_0639 HPV225_0640
HPXHMPREF0462_0779(hydB) HMPREF0462_0780
HENHPSNT_03245 HPSNT_03250
HPHHPLT_03145 HPLT_03150
HEGHPGAM_03245 HPGAM_03250
HPNHPIN_03485 HPIN_03490
HEPHPPN120_03120 HPPN120_03125
HEUHPPN135_03120 HPPN135_03125
HESHPSA_02975 HPSA_02980
HPYSHPSA20_0657 HPSA20_0658
HCNHPB14_03515 HPB14_03520
HPDKHP_0688(hydB) KHP_0689(hyaA)
HEYMWE_0877 MWE_0878
HERC695_03270 C695_03275
HEIC730_03270 C730_03275
HPYAHPAKL117_02980 HPAKL117_02985
HPYKHPAKL86_04445 HPAKL86_04450
HPYOHPOK113_0646(hyaA) HPOK113_0647(hyaB)
HPYLHPOK310_0706(hyaB) HPOK310_0707(hyaA)
HPYBHPOKI102_03855 HPOKI102_03860
HPYCHPOKI112_03885 HPOKI112_03890
HPYDHPOKI128_03010 HPOKI128_03015
HPYEHPOKI154_03225 HPOKI154_03230
HPYFHPOKI422_03860 HPOKI422_03865
HPYGHPOKI673_03205 HPOKI673_03210
HPYHHPOKI828_03215 HPOKI828_03220
HPYJHPOKI898_03855 HPOKI898_03860
HPYRK747_07235 K747_07245
HPYIK750_05455 K750_05460
HPYUK751_03790 K751_09435
HPYMK749_01870 K749_01880
HEMK748_00360 K748_00365
HEBU063_0934 U063_0935
HEZU064_0938 U064_0939
HHEHH_0056(hyaA) HH_0057(hyaB) HH_0198
HACHac_0744(hyaA) Hac_0745(hyaB)
HMSHMU06120(hydA2) HMU09900(hydB) HMU09910(hydA)
HFEHFELIS_12820(hydB) HFELIS_12830(hydA)
HBIHBZC1_10190 HBZC1_10200
HCEHCW_06145 HCW_06150 HCW_07655
HCMHCD_01200 HCD_01205
HCPHCN_1167(hyaA) HCN_1168(hyaB) HCN_1570
HCBHCBAA847_0800(hyaB) HCBAA847_0801(hyaA) HCBAA847_1797
HHMBN341_16420 BN341_16430
HTYBN2458_PEG0808 BN2458_PEG0809 BN2458_PEG1490
HBLXJ32_05685 XJ32_09595 XJ32_09600
HADCDV25_05125 CDV25_05130
HCLNCTC13205_00243(hyaA) NCTC13205_00244(hyaB) NCTC13205_01124(hydA)
HWIA0Z60_00320 A0Z60_00325
HSHNHP194022_12670(hydA) NHP194022_12690(hydB)
HPULNCTC13154_01288(hyaA) NCTC13154_01289(hyaB)
HAILASB7_01380 ASB7_01390
WSUWS1686 WS1687(HYDA)
TDNSuden_1435 Suden_1436
SUASaut_1309 Saut_1310
SULNFJR47_05945 FJR47_05950 FJR47_06660 FJR47_06665
SULGFJR48_01020 FJR48_01025 FJR48_04205 FJR48_04210
SULCCVO_02800 CVO_02805 CVO_03520 CVO_03525
SPALFM071_10500 FM071_10505
SSEIFJR45_03525 FJR45_03530 FJR45_05105 FJR45_05110
SBALHUE88_03515 HUE88_03520
SMASHUE87_08005 HUE87_08010 HUE87_08760 HUE87_08765
SMAXFJR03_06230
SAQTGJV85_07505 GJV85_07510 GJV85_07570
SKUSulku_2051 Sulku_2052 Sulku_2056 Sulku_2057
SULRB649_09615 B649_09620 B649_09665 B649_09670
CJECj1266c(hydB) Cj1267c(hydA) Cj1399c(hydA2)
CJBBN148_1266c(hydB) BN148_1267c(hydA) BN148_1399c(hydA2)
CJJCJJ81176_1282(hydB) CJJ81176_1283(hydA) CJJ81176_1398
CJUC8J_1210(hydB) C8J_1211(hydA) C8J_1313(hydA2)
CJNICDCCJ07001_1213 ICDCCJ07001_1214 ICDCCJ07001_1330
CJICJSA_1205(hydB) CJSA_1206(hydA) CJSA_1330(hydA2)
CJMCJM1_1247(hydB) CJM1_1248(hydA) CJM1_1356(hydA2)
CJSCJS3_1311(hydB) CJS3_1312(hydA) CJS3_1494
CJPA911_06150 A911_06155 A911_06805
CJEJN564_01230 N564_01231 N564_01396
CJEUN565_01271 N565_01272 N565_01436
CJENN755_01266 N755_01267 N755_01433
CJEIN135_01299 N135_01300 N135_01488
CJERH730_07285 H730_07290 H730_07950
CJVMTVDSCj20_1271(hydB) MTVDSCj20_1272(hydA) MTVDSCj20_1375
CJYQZ67_01345(hydB) QZ67_01346(hydA_2) QZ67_01534(hydA_4)
CJQUC78_1217(hydB) UC78_1218(hydA_1) UC78_1341(hydA_2)
CJLPJ17_06460 PJ17_06465 PJ17_07365
CJWPJ18_06265 PJ18_06270
CJRCJE1402(hydB) CJE1403(hydA) CJE1586
CJDJJD26997_0458(hydA) JJD26997_0459(hydB) JJD26997_1733
CJZM635_02020 M635_02025 M635_02670
CJXBN867_12600 BN867_12610 BN867_13790
CFFCFF8240_0939 CFF8240_0940
CFTCFF04554_0940(hydB) CFF04554_0941(hydA)
CFVCFVI03293_0815(hydB)
CFXCFV97608_1000(hydB)
CFZCSG_10510 CSG_10530
CAMPCFT03427_0932(hydB) CFT03427_0933(hydA)
CFPCR44_04735 CR44_04740
CCVCCV52592_1902(hydB) CCV52592_1903(hydA)
CHACHAB381_0861 CHAB381_0862
CCOCCC13826_0100(hydB) CCC13826_0101(hydA)
CCOCCCON33237_1010(hydB) CCON33237_1011(hydA)
CLACLA_0414 CLA_0712(hydA) CLA_0713(hydB)
CLRUPTC16701_0410 UPTC16701_0726(hydA) UPTC16701_0727(hydB)
CLMUPTC16712_0416 UPTC16712_0727(hydA) UPTC16712_0728(hydB)
CLQUPTC4110_0410 UPTC4110_0730(hydA) UPTC4110_0731(hydB)
CLNUPTC3659_0430 UPTC3659_0819(hydA) UPTC3659_0820(hydB)
CLLCONCH_0417 CONCH_0724(hydA) CONCH_0725(hydB)
CCOLBN865_07400 BN865_15080c BN865_15090c
CCCG157_01850 G157_05795 G157_05800
CCQN149_0565 N149_0566 N149_1360
CCFYSQ_01875 YSQ_06335 YSQ_06340
CCYYSS_02705 YSS_02710 YSS_07545
CCOIYSU_01910 YSU_05975 YSU_05980
CCOFVC76_02990(hydA_2) VC76_02995(hydB) VC76_07000(hydA_3)
CCOOATE51_00766(hydA_1) ATE51_02402(hydB) ATE51_02404(hydA_2)
CAJCIG1485E_0982(hydB) CIG1485E_0983(hydA)
CISCINS_0691(hydA) CINS_0692(hydB)
CVOCVOL_0404 CVOL_0704(hydA) CVOL_0705(hydB)
CPELCPEL_0424 CPEL_0781(hydA) CPEL_0782(hydB)
CAMRCAQ16704_0430 CAQ16704_0832(hydB) CAQ16704_0833(hydA)
CSMCSUB8521_0448 CSUB8521_0760(hydA) CSUB8521_0761(hydB)
CSFCSUB8523_0434 CSUB8523_0848(hydA) CSUB8523_0849(hydB)
CGRACGRAC_1164(hydB) CGRAC_1165(hydA)
CURECUREO_0784(hydA) CUREO_0785(hydB)
CHYOCHH_0992(hydB) CHH_0993(hydA)
CHVCHELV3228_0165 CHELV3228_0505(hydA) CHELV3228_0506(hydB)
CSPFCSF_1191(hydA) CSF_1192(hydB)
CCUNCCUN_0543 CCUN_1375(hydB) CCUN_1376(hydA)
CLXCLAN_1091(hydB) CLAN_1092(hydA)
CAVICAV_0707(hydA) CAV_0708(hydB) CAV_1139
CHWA2J15_000685 A2J15_000690
CAMZCVIC12175_1053(hydB) CVIC12175_1054(hydA)
CAMYCSUIS_1177(hydB) CSUIS_1178(hydA)
COJCORN_0421 CORN_0802(hydA) CORN_0803(hydB)
CUXCUP3940_1174(hydB) CUP3940_1175(hydA) CUP3940_1521
CGEOCGEO_0954(hydA) CGEO_0955(hydB)
CBLACBLAS_0966(hydA) CBLAS_0967(hydB)
CCORCCORG_0887(hydB) CCORG_0888(hydA)
CARMCARM_0395 CARM_0781(hydA) CARM_0782(hydB)
CMUCCMCT_0938(hydB) CMCT_0939(hydA)
CSHOCSHOW_0922(hydA) CSHOW_0923(hydB)
CINFCINF_1429(hydB) CINF_1430(hydA)
CNVCNZW441b_0417(hydA) CNZW441b_0418(hydB) CNZW441b_1279
CVUCVULP_0454(hydA) CVULP_0455(hydB) CVULP_1556
SDLSdel_1105 Sdel_1106
SBASulba_1144 Sulba_1145
SMULSMUL_1423(hydA) SMUL_1424(hydB)
SHALSHALO_1400 SHALO_1401
SULSSdiek1_1468 Sdiek1_1469
SULJSJPD1_1403 SJPD1_1404
SULTFA592_13255 FA592_13260
ABUAbu_1427(hydB) Abu_1428(hydA) Abu_1434(hyaB) Abu_1435(hyaA)
ABTABED_1331 ABED_1332 ABED_1338 ABED_1339
ABLA7H1H_1448(hydB) A7H1H_1449(hydA) A7H1H_1453(hyaB) A7H1H_1454(hyaA)
ASKEI285_09010 EI285_09015
ATPATR_1926(hyaB) ATR_1927(hyaA)
ACIBACBT_1261(hyaB) ACBT_1262(hyaA)
ACREACRYA_0484(hyaA) ACRYA_0485(hyaB)
ALANALANTH_0943(hyaA) ALANTH_0944(hyaB)
AFCAFAEC_1174(hyaB) AFAEC_1175(hyaA)
ATHRATH_1842(hydB) ATH_1843(hydA)
ANTArnit_0035 Arnit_0036 Arnit_1360 Arnit_1361 Arnit_1365 Arnit_1366
AELLAELL_1809(hyaB) AELL_1810(hyaA)
AAQIAAQM_1642(hyaB) AAQM_1643(hyaA)
ASUIASUIS_1066(hyaA) ASUIS_1067(hyaB) ASUIS_1072(hydA) ASUIS_1073(hydB)
ACLOACLO_1622(hyaB) ACLO_1623(hyaA)
AVPAVENP_1244(hyaA) AVENP_1245(hyaB) AVENP_2883(hydB) AVENP_2884(hydA)
ADZADFLV_1948(hyaB) ADFLV_1949(hyaA)
ARCABLL_1908 ABLL_1909
PACOAACT_0065 AACT_0066 AACT_1896(hyaB) AACT_1897(hyaA)
APOCAPORC_1965(hydB) APORC_1966(hydA)
AROSNJU99_06245 NJU99_06250
ALKALEK_1485(hyaA) ALEK_1486(hyaB) ALEK_1493(hydA) ALEK_1494(hydB)
ALPLPB137_07805 LPB137_07810
AHSAHALO_1105(hydA) AHALO_1106(hydB)
AMYTAMYT_1212(hyaA) AMYT_1213(hyaB) AMYT_1217(hydA) AMYT_1218(hydB)
AMARAMRN_1096(hydA) AMRN_1097(hydB)
ACAAACAN_1146(hydA) ACAN_1147(hydB)
AMOLAMOL_1077(hyaA) AMOL_1078(hyaB) AMOL_1082(hydA) AMOL_1083(hydB)
APAIAPAC_0036 APAC_1019(hyaA) APAC_1020(hyaB)
HBVABIV_1736(hydB) ABIV_1737(hydA) ABIV_1741(hyaB) ABIV_1742(hyaA)
HEBRAEBR_1135(hyaA) AEBR_1136(hyaB) AEBR_1140(hydA) AEBR_1141(hydB)
AANAAANAER_1110(hyaA) AANAER_1111(hyaB) AANAER_1115(hydA) AANAER_1116(hydB)
HYONNO_1689 NNO_1690
HTMRZR91_02015 RZR91_02020 RZR91_11080 RZR91_11085 RZR91_12490 RZR91_12495
HCJHCR_08090 HCR_08100(hyaA)
NSANitsa_0074 Nitsa_0075
SUNSUN_1652 SUN_1653 SUN_1662 SUN_1663
SINUIMZ28_06630 IMZ28_06635 IMZ28_06680 IMZ28_06685 IMZ28_06705 IMZ28_06710 IMZ28_10450 IMZ28_10455
SMABLN246_01910 LN246_01915 LN246_07645 LN246_14495
NISNIS_0963 NIS_0964
NAMNAMH_0574 NAMH_0575
NAPC3L23_03010 C3L23_03015
CMEDFE773_04140 FE773_04145 FE773_05615 FE773_05620
CPAFC6V80_06595 C6V80_06600
HMRHipma_1097
DAVDESACE_00635 DESACE_00640
DAKDaAHT2_0894 DaAHT2_0895
SAYTPY_2250 TPY_2251
SAPSulac_3618 Sulac_3619
STHRBXT84_13760 BXT84_13765
HFVR50_1064(hynA) R50_1065(hynB)
MMEHM5I08_01670
MEAPMTHMO_1378(hynA) MTHMO_1379(hynB)
SAFSULAZ_0754 SULAZ_0755(hynL)
PMXPERMA_0695 PERMA_0696
DINSelin_1084 Selin_1085
 » show all
Reference
1  [PMID:1587288]
  Authors
Dross F, Geisler V, Lenger R, Theis F, Krafft T, Fahrenholz F, Kojro E, Duchene A, Tripier D, Juvenal K, et al.
  Title
The quinone-reactive Ni/Fe-hydrogenase of Wolinella succinogenes.
  Journal
Eur J Biochem 206:93-102 (1992)
DOI:10.1111/j.1432-1033.1992.tb16905.x
  Sequence
Reference
2  [PMID:8319698]
  Authors
Dross F, Geisler V, Lenger R, Theis F, Krafft T, Fahrenholz F, Kojro E, Duchene A, Tripier D, Juvenal K, et al.
  Title
The quinone-reactive Ni/Fe-hydrogenase of Wolinella Succinogenes.
  Journal
Eur J Biochem 214:949-50 (1993)
DOI:10.1111/j.1432-1033.1993.tb17999.x
  Sequence
Reference
3  [PMID:9822828]
  Authors
Gross R, Simon J, Lancaster CR, Kroger A.
  Title
Identification of histidine residues in Wolinella succinogenes hydrogenase that are essential for menaquinone reduction by H2.
  Journal
Mol Microbiol 30:639-46 (1998)
DOI:10.1046/j.1365-2958.1998.01100.x
Reference
4  [PMID:9310376]
  Authors
Bernhard M, Benelli B, Hochkoeppler A, Zannoni D, Friedrich B.
  Title
Functional and structural role of the cytochrome b subunit of the membrane-bound hydrogenase complex of Alcaligenes eutrophus H16.
  Journal
Eur J Biochem 248:179-86 (1997)
DOI:10.1111/j.1432-1033.1997.00179.x
Reference
5  [PMID:8354459]
  Authors
Ferber DM, Maier RJ.
  Title
Hydrogen-ubiquinone oxidoreductase activity by the Bradyrhizobium japonicum membrane-bound hydrogenase.
  Journal
FEMS Microbiol Lett 110:257-64 (1993)
DOI:10.1111/j.1574-6968.1993.tb06331.x
Reference
6
  Authors
Ishii, M., Omori, T., Igarashi, Y., Adachi, O., Ameyama, M. and Kodama, T.
  Title
Methionaquinone is a direct natural electron-acceptor for the membrane-bound hydrogenase in Hydrogenobacter thermophilus strain TK-6.
  Journal
Agric Biol Chem 55:3011-3016 (1991)
Other DBs
ExplorEnz - The Enzyme Database: 1.12.5.1
IUBMB Enzyme Nomenclature: 1.12.5.1
ExPASy - ENZYME nomenclature database: 1.12.5.1
BRENDA, the Enzyme Database: 1.12.5.1
CAS: 151616-65-8

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