Entry
Name
hydrogen:quinone oxidoreductase;
hydrogen-ubiquinone oxidoreductase;
hydrogen:menaquinone oxidoreductase;
membrane-bound hydrogenase;
quinone-reactive Ni/Fe-hydrogenase
Class
Oxidoreductases;
Acting on hydrogen as donor;
With a quinone or similar compound as acceptor
BRITE hierarchy
Sysname
hydrogen:quinone oxidoreductase
Reaction(IUBMB)
H2 + menaquinone = menaquinol [RN:
R02965 ]
Reaction(KEGG)
Substrate
Product
Comment
Contains nickel, iron-sulfur clusters and cytochrome b. Also catalyses the reduction of water-soluble quinones (e.g. 2,3-dimethylnaphthoquinone) or viologen dyes (benzyl viologen or methyl viologen).
History
EC 1.12.5.1 created 1999 as EC 1.12.99.3, transferred 2002 to EC 1.12.5.1
Orthology
K05922 quinone-reactive Ni/Fe-hydrogenase large subunit
K05927 quinone-reactive Ni/Fe-hydrogenase small subunit
Genes
PDS : CAY62_05940 CAY62_05945
SON : SO_2098(hyaB) SO_2099(hyaA)
SBM : Shew185_1914 Shew185_1915
SBN : Sbal195_1921 Sbal195_1922
SBP : Sbal223_2404 Sbal223_2405
SBT : Sbal678_1960 Sbal678_1961
SBS : Sbal117_2006 Sbal117_2007
SBB : Sbal175_2465 Sbal175_2466
SPC : Sputcn32_2088 Sputcn32_2089
SHP : Sput200_1921 Sput200_1922
SHE : Shewmr4_1821 Shewmr4_1822
SHM : Shewmr7_2155 Shewmr7_2156
SHN : Shewana3_1879 Shewana3_1880
SHW : Sputw3181_1923 Sputw3181_1924
SHF : CEQ32_05685 CEQ32_05690
SJA : SJ2017_2000 SJ2017_2001
SBJ : CF168_11330 CF168_11335
SMAV : CFF01_10565 CFF01_10570
SHEW : CKQ84_18175 CKQ84_18180
SALG : BS332_18620 BS332_18625
SLJ : EGC82_10660 EGC82_10665
SPOL : FH971_09430 FH971_09435
SKH : STH12_01355(hydB) STH12_01356(hydA)
SAES : HBH39_13550 HBH39_13555
SLIT : JQC75_08375 JQC75_08380
SDK : KHX94_17960(hyaB) KHX94_17965(hyaA) KHX94_17975 KHX94_17980(hyaA)
SCAA : TUM17387_21020(hyaA) TUM17387_21030(hyaB)
SEUR : FM038_010610(hyaB) FM038_010615(hyaA)
SYK : KDN34_08530 KDN34_08535 KDN34_08545 KDN34_08550
SCYP : JYB88_09280 JYB88_09285
SAVI : JYB87_09490 JYB87_09495 JYB87_09505 JYB87_09510
SSEM : JYB85_09495 JYB85_09500
SGLA : FJ709_09540 FJ709_09545
SINV : K8B83_12375(hyaB) K8B83_12380(hyaA)
SXM : MKD32_09155(hyaB) MKD32_09160(hyaA)
SVM : KDH10_001071 KDH10_001072
SHEJ : MZ182_10460(hyaA) MZ182_10465(hyaB)
SSEH : N7V09_13985(hyaA) N7V09_13990(hyaB)
SCHK : GII14_10580 GII14_10585
SACH : K0H61_07930(hyaB) K0H61_07935(hyaA)
SAEG : K0H80_08940(hyaB) K0H80_08945(hyaA)
SDEO : D0436_11285(hyaA) D0436_11290(hyaB)
SMES : K0I73_08180(hyaB) K0I73_08185(hyaA)
SHAO : K0H81_10970(hyaA) K0H81_10975(hyaB)
SZH : K0H63_09045(hyaB) K0H63_09050(hyaA)
SSPA : K0I31_09090(hyaB) K0I31_09095(hyaA)
SHNS : K0J45_08905(hyaB) K0J45_08910(hyaA)
SRHS : K0I63_09035(hyaB) K0I63_09040(hyaA)
SPSJ : K0I62_08665(hyaB) K0I62_08670(hyaA)
SMAY : K0H60_09515(hyaB) K0H60_09520(hyaA)
SOG : RA178_12800(hyaA) RA178_12805(hyaB)
SPSR : EGC80_15510 EGC80_15515
FBL : Fbal_1090 Fbal_1091 Fbal_3143 Fbal_3144
FES : HER31_05840 HER31_05845
HEO : C694_03265 C694_03270
HPJ : jhp_0574(hyaA) jhp_0575(hyaB)
HPA : HPAG1_0614 HPAG1_0615
HPS : HPSH_03705 HPSH_03710
HHP : HPSH112_03855 HPSH112_03860
HHQ : HPSH169_03245 HPSH169_03250
HHR : HPSH417_03055 HPSH417_03060
HPG : HPG27_592(hydA) HPG27_593(hydB)
HPP : HPP12_0643(hydA) HPP12_0644(hydB)
HPB : HELPY_0739(hydB) HELPY_0740(hydA)
HPL : HPB8_831(hydA) HPB8_832(hydB)
HPC : HPPC_03185 HPPC_03190
HCA : HPPC18_03040 HPPC18_03045
HPM : HPSJM_03205 HPSJM_03210
HPE : HPELS_03385 HPELS_03390
HPO : HMPREF4655_20967(hydB) HMPREF4655_20968
HPI : hp908_0642 hp908_0643
HPQ : hp2017_0619 hp2017_0620
HPW : hp2018_0620 hp2018_0621
HPU : HPCU_03435 HPCU_03440
HEF : HPF16_0728(hyaB) HPF16_0729(hyaA)
HPF : HPF30_0695(hyaB) HPF30_0696(hyaA)
HEQ : HPF32_0608(hyaA) HPF32_0609(hyaB)
HEX : HPF57_0655(hyaA) HPF57_0656(hyaB)
HPT : HPSAT_03630 HPSAT_03635
HPZ : HPKB_0711(hyaB) HPKB_0712(hyaA)
HPV : HPV225_0639 HPV225_0640
HPX : HMPREF0462_0779(hydB) HMPREF0462_0780
HEN : HPSNT_03245 HPSNT_03250
HPH : HPLT_03145 HPLT_03150
HEG : HPGAM_03245 HPGAM_03250
HPN : HPIN_03485 HPIN_03490
HEP : HPPN120_03120 HPPN120_03125
HEU : HPPN135_03120 HPPN135_03125
HES : HPSA_02975 HPSA_02980
HPYS : HPSA20_0657 HPSA20_0658
HCN : HPB14_03515 HPB14_03520
HPD : KHP_0688(hydB) KHP_0689(hyaA)
HER : C695_03270 C695_03275
HEI : C730_03270 C730_03275
HPYA : HPAKL117_02980 HPAKL117_02985
HPYK : HPAKL86_04445 HPAKL86_04450
HPYO : HPOK113_0646(hyaA) HPOK113_0647(hyaB)
HPYL : HPOK310_0706(hyaB) HPOK310_0707(hyaA)
HPYB : HPOKI102_03855 HPOKI102_03860
HPYC : HPOKI112_03885 HPOKI112_03890
HPYD : HPOKI128_03010 HPOKI128_03015
HPYE : HPOKI154_03225 HPOKI154_03230
HPYF : HPOKI422_03860 HPOKI422_03865
HPYG : HPOKI673_03205 HPOKI673_03210
HPYH : HPOKI828_03215 HPOKI828_03220
HPYJ : HPOKI898_03855 HPOKI898_03860
HPYR : K747_07235 K747_07245
HPYI : K750_05455 K750_05460
HPYU : K751_03790 K751_09435
HPYM : K749_01870 K749_01880
HEM : K748_00360 K748_00365
HHE : HH_0056(hyaA) HH_0057(hyaB) HH_0198
HAC : Hac_0744(hyaA) Hac_0745(hyaB)
HMS : HMU06120(hydA2) HMU09900(hydB) HMU09910(hydA)
HFE : HFELIS_12820(hydB) HFELIS_12830(hydA)
HBI : HBZC1_10190 HBZC1_10200
HCE : HCW_06145 HCW_06150 HCW_07655
HCP : HCN_1167(hyaA) HCN_1168(hyaB) HCN_1570
HCB : HCBAA847_0800(hyaB) HCBAA847_0801(hyaA) HCBAA847_1797
HHM : BN341_16420 BN341_16430
HTY : BN2458_PEG0808 BN2458_PEG0809 BN2458_PEG1490
HBL : XJ32_05685 XJ32_09595 XJ32_09600
HAD : CDV25_05125 CDV25_05130
HCL : NCTC13205_00243(hyaA) NCTC13205_00244(hyaB) NCTC13205_01124(hydA)
HWI : A0Z60_00320 A0Z60_00325
HSH : NHP194022_12670(hydA) NHP194022_12690(hydB)
HPUL : NCTC13154_01288(hyaA) NCTC13154_01289(hyaB)
HAIL : ASB7_01380 ASB7_01390
TDN : Suden_1435 Suden_1436
SULN : FJR47_05945 FJR47_05950 FJR47_06660 FJR47_06665
SULG : FJR48_01020 FJR48_01025 FJR48_04205 FJR48_04210
SULC : CVO_02800 CVO_02805 CVO_03520 CVO_03525
SPAL : FM071_10500 FM071_10505
SSEI : FJR45_03525 FJR45_03530 FJR45_05105 FJR45_05110
SBAL : HUE88_03515 HUE88_03520
SMAS : HUE87_08005 HUE87_08010 HUE87_08760 HUE87_08765
SAQT : GJV85_07505 GJV85_07510 GJV85_07570
SKU : Sulku_2051 Sulku_2052 Sulku_2056 Sulku_2057
SULR : B649_09615 B649_09620 B649_09665 B649_09670
CJE : Cj1266c(hydB) Cj1267c(hydA) Cj1399c(hydA2)
CJB : BN148_1266c(hydB) BN148_1267c(hydA) BN148_1399c(hydA2)
CJJ : CJJ81176_1282(hydB) CJJ81176_1283(hydA) CJJ81176_1398
CJU : C8J_1210(hydB) C8J_1211(hydA) C8J_1313(hydA2)
CJN : ICDCCJ07001_1213 ICDCCJ07001_1214 ICDCCJ07001_1330
CJI : CJSA_1205(hydB) CJSA_1206(hydA) CJSA_1330(hydA2)
CJM : CJM1_1247(hydB) CJM1_1248(hydA) CJM1_1356(hydA2)
CJS : CJS3_1311(hydB) CJS3_1312(hydA) CJS3_1494
CJP : A911_06150 A911_06155 A911_06805
CJEJ : N564_01230 N564_01231 N564_01396
CJEU : N565_01271 N565_01272 N565_01436
CJEN : N755_01266 N755_01267 N755_01433
CJEI : N135_01299 N135_01300 N135_01488
CJER : H730_07285 H730_07290 H730_07950
CJV : MTVDSCj20_1271(hydB) MTVDSCj20_1272(hydA) MTVDSCj20_1375
CJY : QZ67_01345(hydB) QZ67_01346(hydA_2) QZ67_01534(hydA_4)
CJQ : UC78_1217(hydB) UC78_1218(hydA_1) UC78_1341(hydA_2)
CJL : PJ17_06460 PJ17_06465 PJ17_07365
CJW : PJ18_06265 PJ18_06270
CJR : CJE1402(hydB) CJE1403(hydA) CJE1586
CJD : JJD26997_0458(hydA) JJD26997_0459(hydB) JJD26997_1733
CJZ : M635_02020 M635_02025 M635_02670
CJX : BN867_12600 BN867_12610 BN867_13790
CFF : CFF8240_0939 CFF8240_0940
CFT : CFF04554_0940(hydB) CFF04554_0941(hydA)
CFV : CFVI03293_0815(hydB)
CAMP : CFT03427_0932(hydB) CFT03427_0933(hydA)
CFP : CR44_04735 CR44_04740
CCV : CCV52592_1902(hydB) CCV52592_1903(hydA)
CHA : CHAB381_0861 CHAB381_0862
CCO : CCC13826_0100(hydB) CCC13826_0101(hydA)
CCOC : CCON33237_1010(hydB) CCON33237_1011(hydA)
CLA : CLA_0414 CLA_0712(hydA) CLA_0713(hydB)
CLR : UPTC16701_0410 UPTC16701_0726(hydA) UPTC16701_0727(hydB)
CLM : UPTC16712_0416 UPTC16712_0727(hydA) UPTC16712_0728(hydB)
CLQ : UPTC4110_0410 UPTC4110_0730(hydA) UPTC4110_0731(hydB)
CLN : UPTC3659_0430 UPTC3659_0819(hydA) UPTC3659_0820(hydB)
CLL : CONCH_0417 CONCH_0724(hydA) CONCH_0725(hydB)
CCOL : BN865_07400 BN865_15080c BN865_15090c
CCC : G157_01850 G157_05795 G157_05800
CCQ : N149_0565 N149_0566 N149_1360
CCF : YSQ_01875 YSQ_06335 YSQ_06340
CCY : YSS_02705 YSS_02710 YSS_07545
CCOI : YSU_01910 YSU_05975 YSU_05980
CCOF : VC76_02990(hydA_2) VC76_02995(hydB) VC76_07000(hydA_3)
CCOO : ATE51_00766(hydA_1) ATE51_02402(hydB) ATE51_02404(hydA_2)
CAJ : CIG1485E_0982(hydB) CIG1485E_0983(hydA)
CIS : CINS_0691(hydA) CINS_0692(hydB)
CVO : CVOL_0404 CVOL_0704(hydA) CVOL_0705(hydB)
CPEL : CPEL_0424 CPEL_0781(hydA) CPEL_0782(hydB)
CAMR : CAQ16704_0430 CAQ16704_0832(hydB) CAQ16704_0833(hydA)
CSM : CSUB8521_0448 CSUB8521_0760(hydA) CSUB8521_0761(hydB)
CSF : CSUB8523_0434 CSUB8523_0848(hydA) CSUB8523_0849(hydB)
CGRA : CGRAC_1164(hydB) CGRAC_1165(hydA)
CURE : CUREO_0784(hydA) CUREO_0785(hydB)
CHYO : CHH_0992(hydB) CHH_0993(hydA)
CHV : CHELV3228_0165 CHELV3228_0505(hydA) CHELV3228_0506(hydB)
CSPF : CSF_1191(hydA) CSF_1192(hydB)
CCUN : CCUN_0543 CCUN_1375(hydB) CCUN_1376(hydA)
CLX : CLAN_1091(hydB) CLAN_1092(hydA)
CAVI : CAV_0707(hydA) CAV_0708(hydB) CAV_1139
CHW : A2J15_000685 A2J15_000690
CAMZ : CVIC12175_1053(hydB) CVIC12175_1054(hydA)
CAMY : CSUIS_1177(hydB) CSUIS_1178(hydA)
COJ : CORN_0421 CORN_0802(hydA) CORN_0803(hydB)
CUX : CUP3940_1174(hydB) CUP3940_1175(hydA) CUP3940_1521
CGEO : CGEO_0954(hydA) CGEO_0955(hydB)
CBLA : CBLAS_0966(hydA) CBLAS_0967(hydB)
CCOR : CCORG_0887(hydB) CCORG_0888(hydA)
CARM : CARM_0395 CARM_0781(hydA) CARM_0782(hydB)
CMUC : CMCT_0938(hydB) CMCT_0939(hydA)
CSHO : CSHOW_0922(hydA) CSHOW_0923(hydB)
CINF : CINF_1429(hydB) CINF_1430(hydA)
CNV : CNZW441b_0417(hydA) CNZW441b_0418(hydB) CNZW441b_1279
CVU : CVULP_0454(hydA) CVULP_0455(hydB) CVULP_1556
SBA : Sulba_1144 Sulba_1145
SMUL : SMUL_1423(hydA) SMUL_1424(hydB)
SHAL : SHALO_1400 SHALO_1401
SULS : Sdiek1_1468 Sdiek1_1469
SULJ : SJPD1_1403 SJPD1_1404
SULT : FA592_13255 FA592_13260
ABU : Abu_1427(hydB) Abu_1428(hydA) Abu_1434(hyaB) Abu_1435(hyaA)
ABT : ABED_1331 ABED_1332 ABED_1338 ABED_1339
ABL : A7H1H_1448(hydB) A7H1H_1449(hydA) A7H1H_1453(hyaB) A7H1H_1454(hyaA)
ASK : EI285_09010 EI285_09015
ATP : ATR_1926(hyaB) ATR_1927(hyaA)
ACIB : ACBT_1261(hyaB) ACBT_1262(hyaA)
ACRE : ACRYA_0484(hyaA) ACRYA_0485(hyaB)
ALAN : ALANTH_0943(hyaA) ALANTH_0944(hyaB)
AFC : AFAEC_1174(hyaB) AFAEC_1175(hyaA)
ATHR : ATH_1842(hydB) ATH_1843(hydA)
ANT : Arnit_0035 Arnit_0036 Arnit_1360 Arnit_1361 Arnit_1365 Arnit_1366
AELL : AELL_1809(hyaB) AELL_1810(hyaA)
AAQI : AAQM_1642(hyaB) AAQM_1643(hyaA)
ASUI : ASUIS_1066(hyaA) ASUIS_1067(hyaB) ASUIS_1072(hydA) ASUIS_1073(hydB)
ACLO : ACLO_1622(hyaB) ACLO_1623(hyaA)
AVP : AVENP_1244(hyaA) AVENP_1245(hyaB) AVENP_2883(hydB) AVENP_2884(hydA)
ADZ : ADFLV_1948(hyaB) ADFLV_1949(hyaA)
PACO : AACT_0065 AACT_0066 AACT_1896(hyaB) AACT_1897(hyaA)
APOC : APORC_1965(hydB) APORC_1966(hydA)
AROS : NJU99_06245 NJU99_06250
ALK : ALEK_1485(hyaA) ALEK_1486(hyaB) ALEK_1493(hydA) ALEK_1494(hydB)
ALP : LPB137_07805 LPB137_07810
AHS : AHALO_1105(hydA) AHALO_1106(hydB)
AMYT : AMYT_1212(hyaA) AMYT_1213(hyaB) AMYT_1217(hydA) AMYT_1218(hydB)
AMAR : AMRN_1096(hydA) AMRN_1097(hydB)
ACAA : ACAN_1146(hydA) ACAN_1147(hydB)
AMOL : AMOL_1077(hyaA) AMOL_1078(hyaB) AMOL_1082(hydA) AMOL_1083(hydB)
APAI : APAC_0036 APAC_1019(hyaA) APAC_1020(hyaB)
HBV : ABIV_1736(hydB) ABIV_1737(hydA) ABIV_1741(hyaB) ABIV_1742(hyaA)
HEBR : AEBR_1135(hyaA) AEBR_1136(hyaB) AEBR_1140(hydA) AEBR_1141(hydB)
AANA : AANAER_1110(hyaA) AANAER_1111(hyaB) AANAER_1115(hydA) AANAER_1116(hydB)
HTM : RZR91_02015 RZR91_02020 RZR91_11080 RZR91_11085 RZR91_12490 RZR91_12495
HCJ : HCR_08090 HCR_08100(hyaA)
NSA : Nitsa_0074 Nitsa_0075
SUN : SUN_1652 SUN_1653 SUN_1662 SUN_1663
SINU : IMZ28_06630 IMZ28_06635 IMZ28_06680 IMZ28_06685 IMZ28_06705 IMZ28_06710 IMZ28_10450 IMZ28_10455
SMAB : LN246_01910 LN246_01915 LN246_07645 LN246_14495
NAP : C3L23_03010 C3L23_03015
CMED : FE773_04140 FE773_04145 FE773_05615 FE773_05620
CPAF : C6V80_06595 C6V80_06600
DAV : DESACE_00635 DESACE_00640
DAK : DaAHT2_0894 DaAHT2_0895
SAP : Sulac_3618 Sulac_3619
STHR : BXT84_13760 BXT84_13765
HFV : R50_1064(hynA) R50_1065(hynB)
MEAP : MTHMO_1378(hynA) MTHMO_1379(hynB)
SAF : SULAZ_0754 SULAZ_0755(hynL)
PMX : PERMA_0695 PERMA_0696
DIN : Selin_1084 Selin_1085
» show all
Taxonomy
Reference
Authors
Dross F, Geisler V, Lenger R, Theis F, Krafft T, Fahrenholz F, Kojro E, Duchene A, Tripier D, Juvenal K, et al.
Title
The quinone-reactive Ni/Fe-hydrogenase of Wolinella succinogenes.
Journal
Sequence
Reference
Authors
Dross F, Geisler V, Lenger R, Theis F, Krafft T, Fahrenholz F, Kojro E, Duchene A, Tripier D, Juvenal K, et al.
Title
The quinone-reactive Ni/Fe-hydrogenase of Wolinella Succinogenes.
Journal
Sequence
Reference
Authors
Gross R, Simon J, Lancaster CR, Kroger A.
Title
Identification of histidine residues in Wolinella succinogenes hydrogenase that are essential for menaquinone reduction by H2.
Journal
Reference
Authors
Bernhard M, Benelli B, Hochkoeppler A, Zannoni D, Friedrich B.
Title
Functional and structural role of the cytochrome b subunit of the membrane-bound hydrogenase complex of Alcaligenes eutrophus H16.
Journal
Reference
Authors
Ferber DM, Maier RJ.
Title
Hydrogen-ubiquinone oxidoreductase activity by the Bradyrhizobium japonicum membrane-bound hydrogenase.
Journal
Reference
6
Authors
Ishii, M., Omori, T., Igarashi, Y., Adachi, O., Ameyama, M. and Kodama, T.
Title
Methionaquinone is a direct natural electron-acceptor for the membrane-bound hydrogenase in Hydrogenobacter thermophilus strain TK-6.
Journal
Agric Biol Chem 55:3011-3016 (1991)
Other DBs
ExplorEnz - The Enzyme Database: 1.12.5.1
ExPASy - ENZYME nomenclature database: 1.12.5.1