Entry
Name
arachidonate 12-lipoxygenase;
Delta12-lipoxygenase;
12-lipoxygenase;
12Delta-lipoxygenase;
C-12 lipoxygenase;
12S-lipoxygenase;
leukotriene A4 synthase;
LTA4 synthase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
arachidonate:oxygen 12-oxidoreductase
Reaction(IUBMB)
arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate [RN:
R01596 ]
Reaction(KEGG)
Substrate
Product
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate [CPD:
C05965 ]
Comment
The product is rapidly reduced to the corresponding 12S-hydroxy compound.
History
EC 1.13.11.31 created 1983
Pathway
ec00590 Arachidonic acid metabolism
Orthology
K00458 arachidonate 12-lipoxygenase
Genes
PTR : 455242(ALOX12) 455243
CSYR : 103263245(ALOX12) 103263247
MMUR : 105878109(ALOX12) 105879294
OGA : 100951876(ALOX12) 100961111
MMU : 11684(Alox12) 11685(Alox12e)
RNO : 287454(Alox12) 303252(Alox12e)
ANU : 117701406 117710866(Alox12) 117711132
MAUA : 101839190 101844629
PROB : 127219012 127219013(Alox12)
MORG : 121456507 121456764
MFOT : 126513995 126514127
AAMP : 119812811 119813474
DORD : 105983295 105983533(Alox12)
NCAR : 124979056 124980537
TUP : 102493396(ALOX12) 102494779
ZCA : 113907925(ALOX12) 113939134
MLX : 117999898 117999978(ALOX12)
BTA : 407169(ALOX12) 787450(ALOX12E)
BBIS : 104993944 104993949(ALOX12)
BTAX : 128064757 128065118
CCAD : 122446320 122446338(ALOX12)
MBEZ : 129542462(ALOX12) 129542473
MYB : 102246619 102248372 102248722 102248980 102249269 102249301 102249603 102249899 102254447(ALOX12) 102255394
MYD : 102753778 102755565 102755847 102768484 102769301 102769599
MMYO : 118672025 118672026 118672027 118672028
MLF : 102428351 102428552 102428668 102428965 102429158 102429663 102429971 102432805 102433118 102435623
PKL : 118726716(ALOX12) 118726717 118726718 118726720 118726721 118727040 118727041 118727042
EFUS : 103296941(ALOX12) 103296942 103296943 103296944 103296945 103296946 103296985 103296986 114227056 129147359 129147360
MMF : 118634472 118634597 118634882
SARA : 101547220(ALOX12) 101547484
MDO : 100015746(ALOX12) 100015831 100015867 100015906 100015945
CAUA : 113052069 113052070 113052072 113105799
CGIB : 127961063 128017081 128017082
MASI : 127413609 127446982
IPU : 108267744 108267745(alox12)
SMEO : 124387847 124387880 124388151
CMAO : 118801227 118801228
LCF : 108879679 108895226(alox12)
SASA : 100380705(lox12) 106608934
STRU : 115194626 115198574
OTW : 112214522(alox12) 112259738
OMY : 110500350(alox12) 110531448
OGO : 124008639 124013533(alox12)
OKE : 118378215 118392202(alox12)
SNH : 120030395 120049296(alox12)
CCLU : 121554183 121571287(alox12)
PSPA : 121305733 121306538
PSEX : 120525266(alox12) 120525267 120525269 120525271 120526494 120526784
CPLA : 122544334 122544390
HOC : 132835132(alox12) 132835215
» show all
Taxonomy
Reference
Authors
Hamberg M, Samuelsson B.
Title
Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets.
Journal
Reference
Authors
Nugteren DH.
Title
Arachidonate lipoxygenase in blood platelets.
Journal
Reference
Authors
Wallach DP, Brown VR.
Title
A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases.
Journal
Other DBs