KEGG   ENZYME: 1.13.11.31
Entry
EC 1.13.11.31               Enzyme                                 
Name
arachidonate 12-lipoxygenase;
Delta12-lipoxygenase;
12-lipoxygenase;
12Delta-lipoxygenase;
C-12 lipoxygenase;
12S-lipoxygenase;
leukotriene A4 synthase;
LTA4 synthase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
arachidonate:oxygen 12-oxidoreductase
Reaction(IUBMB)
arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate [RN:R01596]
Reaction(KEGG)
R01596
Substrate
arachidonate [CPD:C00219];
O2 [CPD:C00007]
Product
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate [CPD:C05965]
Comment
The product is rapidly reduced to the corresponding 12S-hydroxy compound.
History
EC 1.13.11.31 created 1983
Pathway
ec00590  Arachidonic acid metabolism
Orthology
K00458  arachidonate 12-lipoxygenase
Genes
HSA: 239(ALOX12)
PTR: 455242(ALOX12) 455243
PPS: 100992721(ALOX12)
GGO: 101140132(ALOX12)
PON: 100435170 100448016
NLE: 100605486(ALOX12)
HMH: 116458265(ALOX12)
MCC: 713748(ALOX12)
MCF: 102136652(ALOX12)
MTHB: 126939829
MNI: 105473015
CSAB: 103242265(ALOX12)
CATY: 105582822(ALOX12)
PANU: 101012932(ALOX12)
TGE: 112609056(ALOX12)
MLEU: 105549914(ALOX12)
RRO: 104673348(ALOX12)
RBB: 108514395(ALOX12)
TFN: 117067814(ALOX12)
PTEH: 111521261(ALOX12)
CANG: 105523575(ALOX12)
CJC: 100400641(ALOX12)
SBQ: 101051396(ALOX12)
CIMI: 108306615(ALOX12)
CSYR: 103263245(ALOX12) 103263247
MMUR: 105878109(ALOX12) 105879294
LCAT: 123650840(ALOX12)
PCOQ: 105819472(ALOX12)
OGA: 100951876(ALOX12) 100961111
MMU: 11684(Alox12) 11685(Alox12e)
MCAL: 110304778(Alox12)
MPAH: 110331792(Alox12)
RNO: 287454(Alox12) 303252(Alox12e)
MCOC: 116077965
ANU: 117701406 117710866(Alox12) 117711132
MUN: 110540751
CGE: 100764620(Alox12)
MAUA: 101839190 101844629
PROB: 127219012 127219013(Alox12)
PLEU: 114693220(Alox12)
MORG: 121456507 121456764
MFOT: 126513995 126514127
AAMP: 119812811 119813474
NGI: 103752172(Alox12)
HGL: 101702123(Alox12)
CPOC: 100719400
CCAN: 109682903(Alox12)
DORD: 105983295 105983533(Alox12)
DSP: 122100378(Alox12)
PLOP: 125365503(Alox12)
NCAR: 124979056 124980537
MMMA: 107158101(Alox12)
OCU: 100340525
OPI: 101518253(ALOX12)
TUP: 102493396(ALOX12) 102494779
GVR: 103587106(ALOX12)
CFA: 479476(ALOX12)
CLUD: 112647510
VVP: 112924805
VLG: 121500195
NPO: 129497890(ALOX12)
AML: 100471037(ALOX12)
UMR: 103660455(ALOX12)
UAH: 113271099(ALOX12)
UAR: 123792172(ALOX12)
ELK: 111161172
LLV: 125086719 125087074
MPUF: 101684639(ALOX12)
MNP: 132003859(ALOX12)
MLK: 131815812(ALOX12)
NVS: 122906679(ALOX12)
ORO: 101379600(ALOX12)
EJU: 114225417(ALOX12)
ZCA: 113907925(ALOX12) 113939134
MLX: 117999898 117999978(ALOX12)
NSU: 110584560(ALOX12)
LWW: 102750079(ALOX12)
FCA: 101094304
PYU: 121016040(ALOX12)
PCOO: 112856976
PBG: 122484839
PVIV: 125151243(ALOX12)
LRUF: 124519666
PTG: 102969788(ALOX12)
PPAD: 109245992
PUC: 125927078
AJU: 106972408
HHV: 120231410(ALOX12)
BTA: 407169(ALOX12) 787450(ALOX12E)
BOM: 102284543(ALOX12)
BIU: 109574004(ALOX12)
BBUB: 102395651(ALOX12)
BBIS: 104993944 104993949(ALOX12)
CHX: 102187263(ALOX12)
OAS: 101113685(ALOX12)
BTAX: 128064757 128065118
ODA: 120866088(ALOX12)
CCAD: 122446320 122446338(ALOX12)
MBEZ: 129542462(ALOX12) 129542473
SSC: 100620614(ALOX12)
CFR: 102504047(ALOX12)
CBAI: 105077467(ALOX12)
CDK: 105103060(ALOX12)
VPC: 102533742(ALOX12)
BACU: 103020542(ALOX12)
BMUS: 118887046(ALOX12)
LVE: 103074060(ALOX12)
OOR: 101279538(ALOX12)
DLE: 111185974(ALOX12)
PCAD: 102977395(ALOX12)
PSIU: 116745598(ALOX12)
NASI: 112390424(ALOX12)
ECB: 100072916
EPZ: 103561430(ALOX12)
EAI: 106844160(ALOX12)
MYB: 102246619 102248372 102248722 102248980 102249269 102249301 102249603 102249899 102254447(ALOX12) 102255394
MYD: 102753778 102755565 102755847 102768484 102769301 102769599
MMYO: 118672025 118672026 118672027 118672028
MLF: 102428351 102428552 102428668 102428965 102429158 102429663 102429971 102432805 102433118 102435623
PKL: 118726716(ALOX12) 118726717 118726718 118726720 118726721 118727040 118727041 118727042
EFUS: 103296941(ALOX12) 103296942 103296943 103296944 103296945 103296946 103296985 103296986 114227056 129147359 129147360
MNA: 107544244(ALOX12)
DRO: 112308919(ALOX12)
SHON: 118979425(ALOX12)
AJM: 119037160(ALOX12)
PHAS: 123809459
MMF: 118634472 118634597 118634882
PPAM: 129072205(ALOX12)
HAI: 109394599(ALOX12)
RFQ: 117013802(ALOX12)
PALE: 102897481(ALOX12)
PGIG: 120612187(ALOX12)
PVP: 105291977(ALOX12)
RAY: 107509504(ALOX12)
MJV: 108401224
TOD: 119232717
SARA: 101547220(ALOX12) 101547484
LAV: 100656524
TMU: 101341400
ETF: 101643858(ALOX12)
DNM: 101444550
MDO: 100015746(ALOX12) 100015831 100015867 100015906 100015945
GAS: 123243728 123247715
SHR: 100933073
AFZ: 127560919
PCW: 110194257
OAA: 100079469
MUO: 115458185(ALOX12)
GSH: 117350677(ALOX12)
DRE: 322732(alox12)
SRX: 107749792 107750578
SANH: 107669199
SGH: 107593795
CCAR: 109050063
CAUA: 113052069 113052070 113052072 113105799
CGIB: 127961063 128017081 128017082
PTET: 122348592(alox12)
LROH: 127167780(alox12)
OMC: 131543981(alox12)
PPRM: 120487640
RKG: 130102666(alox12)
MAMB: 125264591(alox12)
CIDE: 127515195
MASI: 127413609 127446982
TROS: 130570780(alox12)
TDW: 130422185(alox12)
MANU: 129441089(alox12)
IPU: 108267744 108267745(alox12)
IFU: 128610027 128610036
PHYP: 113539915
SMEO: 124387847 124387880 124388151
TFD: 113635137(alox12)
TVC: 132848618(alox12)
AMEX: 103037595
CMAO: 118801227 118801228
EEE: 113580793
CHAR: 105889668(alox12)
TRU: 101070898
TFS: 130522950(alox12)
LCO: 104937156
NCC: 104948188
TBEN: 117497588(alox12)
CGOB: 115023433
PGEO: 117463440(alox12)
GACU: 117535413(alox12)
EMAC: 134876050(alox12)
ELY: 117272669(alox12)
EFO: 125884070(alox12)
PLEP: 121962177(alox12)
SLUC: 116043997(alox12)
ECRA: 117934769(alox12)
ESP: 116707176
PFLV: 114545687
GAT: 120822087(alox12)
PPUG: 119222432(alox12)
AFB: 129093703(alox12)
CLUM: 117747621(alox12)
PSWI: 130212060(alox12)
MSAM: 119912247(alox12)
SCHU: 122869982(alox12)
CUD: 121506630(alox12)
ALAT: 119026959(alox12)
MZE: 101479810
ONL: 100698983
OAU: 116321155(alox12)
OLA: 101174953
OML: 112155872(alox12)
XMA: 102224924
XCO: 114157899
XHE: 116733267
PRET: 103480141
PFOR: 103148853
PLAI: 106946955
PMEI: 106917266
GAF: 122820467(alox12)
PPRL: 129378384(alox12)
CVG: 107103814
CTUL: 119775005(alox12)
GMU: 124880055(alox12)
NFU: 107384708(alox15)
KMR: 108242243(alox12)
ALIM: 106526983
NWH: 119414629(alox12)
AOCE: 111564179
MCEP: 125000804(alox12)
POV: 109637629
SSEN: 122766699(alox12)
HHIP: 117751994(alox12)
HSP: 118102186(alox12)
SMAU: 118302281(alox12)
LCF: 108879679 108895226(alox12)
SDU: 111223569
SLAL: 111667993
XGL: 120797417(alox12)
PEE: 133398110(alox12)
PTAO: 133473005(alox12)
BPEC: 110170766
MALB: 109957267
BSPL: 114849198(alox12)
SJO: 128383885(alox12)
SASA: 100380705(lox12) 106608934
STRU: 115194626 115198574
OTW: 112214522(alox12) 112259738
OMY: 110500350(alox12) 110531448
OGO: 124008639 124013533(alox12)
ONE: 115122959 115133313
OKI: 109882634 109896866
OKE: 118378215 118392202(alox12)
SALP: 111952161
SNH: 120030395 120049296(alox12)
CCLU: 121554183 121571287(alox12)
ELS: 105027651
SFM: 108922837
PKI: 111846328
AANG: 118223344(alox12)
LOC: 102685586(alox12)
PSPA: 121305733 121306538
ARUT: 117426941
PSEX: 120525266(alox12) 120525267 120525269 120525271 120526494 120526784
CMK: 103190915(alox12)
RTP: 109926716
CPLA: 122544334 122544390
HOC: 132835132(alox12) 132835215
LPIC: 129282967
MMER: 123540522
XEN: 124443531
 » show all
Reference
1  [PMID:4215079]
  Authors
Hamberg M, Samuelsson B.
  Title
Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets.
  Journal
Proc Natl Acad Sci U S A 71:3400-4 (1974)
DOI:10.1073/pnas.71.9.3400
Reference
2  [PMID:804329]
  Authors
Nugteren DH.
  Title
Arachidonate lipoxygenase in blood platelets.
  Journal
Biochim Biophys Acta 380:299-307 (1975)
DOI:10.1016/0005-2760(75)90016-8
Reference
3  [PMID:6783111]
  Authors
Wallach DP, Brown VR.
  Title
A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases.
  Journal
Biochim Biophys Acta 663:361-72 (1981)
DOI:10.1016/0005-2760(81)90165-X
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.31
IUBMB Enzyme Nomenclature: 1.13.11.31
ExPASy - ENZYME nomenclature database: 1.13.11.31
BRENDA, the Enzyme Database: 1.13.11.31
CAS: 82391-43-3

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Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
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Gene (541)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (373)   
   KEGG MGENES (122)   
   RefGene (45)   
Protein sequence (239)   
   UniProt (200)   
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DNA sequence (30)   
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3D Structure (2)   
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Protein domain (10)   
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