KEGG ENZYME: 1.13.11.61

ENZYME: 1.13.11.61

Entry

EC 1.13.11.61               Enzyme

Name

linolenate 9R-lipoxygenase;
NspLOX;
(9R)-LOX;
linoleate 9R-dioxygenase

Class

Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen

Sysname

alpha-linolenate:oxygen (9R)-oxidoreductase

Reaction(IUBMB)

alpha-linolenate + O2 = (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate [RN:R09810]

Reaction(KEGG)

R09810

Substrate

alpha-linolenate [CPD:C06427];
O2 [CPD:C00007]

Product

(9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate [CPD:C19936]

Comment

In cyanobacteria the enzyme is involved in oxylipin biosynthesis. The enzyme also converts linoleate to (9R,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoate.

History

EC 1.13.11.61 created 2011

Orthology

K18031

linolenate 9R-lipoxygenase

Genes

AMR:

AM1_2589

ANA:

all8020

Reference

1 [PMID:20043865]

Authors

Jerneren F, Hoffmann I, Oliw EH

Title

Linoleate 9R-dioxygenase and allene oxide synthase activities of Aspergillus terreus.

Journal

Arch Biochem Biophys 495:67-73 (2010)
DOI:10.1016/j.abb.2009.12.022

Reference

2 [PMID:18439634]

Authors

Andreou AZ, Vanko M, Bezakova L, Feussner I

Title

Properties of a mini 9R-lipoxygenase from Nostoc sp. PCC 7120 and its mutant forms.

Journal

Phytochemistry 69:1832-7 (2008)
DOI:10.1016/j.phytochem.2008.03.002

Reference

3 [PMID:18031288]

Authors

Lang I, Gobel C, Porzel A, Heilmann I, Feussner I

Title

A lipoxygenase with linoleate diol synthase activity from Nostoc sp. PCC 7120.

Journal

Biochem J 410:347-57 (2008)
DOI:10.1042/BJ20071277

Sequence

[ana:all8020]

Other DBs

ExplorEnz - The Enzyme Database:

1.13.11.61

IUBMB Enzyme Nomenclature:

1.13.11.61

ExPASy - ENZYME nomenclature database:

1.13.11.61

BRENDA, the Enzyme Database:

1.13.11.61

DBGET integrated database retrieval system