Entry
Name
hydroquinone 1,2-dioxygenase;
hydroquinone dioxygenase;
benzene-1,4-diol:oxygen 1,2-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
benzene-1,4-diol:oxygen 1,2-oxidoreductase (ring-opening)
Reaction(IUBMB)
benzene-1,4-diol + O2 = (2Z,4E)-4-hydroxy-6-oxohexa-2,4-dienoate [RN:
R05246 ]
Reaction(KEGG)
Substrate
Product
(2Z,4E)-4-hydroxy-6-oxohexa-2,4-dienoate
Comment
The enzyme is an extradiol-type dioxygenase, and is a member of the nonheme-iron(II)-dependent dioxygenase family. It catalyses the ring cleavage of a wide range of hydroquinone substrates to produce the corresponding 4-hydroxymuconic semialdehydes.
History
EC 1.13.11.66 created 2012
Pathway
ec00361 Chlorocyclohexane and chlorobenzene degradation
ec01120 Microbial metabolism in diverse environments
Orthology
K15240 hydroquinone 1,2-dioxygenase
Genes
SINA : KNJ79_19535 KNJ79_19710(linE)
SPMI : K663_19943 K663_22998
Taxonomy
Reference
Authors
Miyauchi K, Adachi Y, Nagata Y, Takagi M
Title
Cloning and sequencing of a novel meta-cleavage dioxygenase gene whose product is involved in degradation of gamma-hexachlorocyclohexane in Sphingomonas paucimobilis.
Journal
Sequence
Reference
Authors
Moonen MJ, Synowsky SA, van den Berg WA, Westphal AH, Heck AJ, van den Heuvel RH, Fraaije MW, van Berkel WJ
Title
Hydroquinone dioxygenase from pseudomonas fluorescens ACB: a novel member of the family of nonheme-iron(II)-dependent dioxygenases.
Journal
Reference
Authors
Shen W, Liu W, Zhang J, Tao J, Deng H, Cao H, Cui Z
Title
Cloning and characterization of a gene cluster involved in the catabolism of p-nitrophenol from Pseudomonas putida DLL-E4.
Journal
Other DBs