Entry Name 2-hydroxyethylphosphonate dioxygenase;
Class Oxidoreductases;BRITE hierarchy
Sysname 2-hydroxyethylphosphonate:oxygen 1,2-oxidoreductase (hydroxymethylphosphonate-forming)
Reaction(IUBMB) 2-hydroxyethylphosphonate + O2 = hydroxymethylphosphonate + formate [RN:
R08864 ]
Reaction(KEGG) Substrate Product Comment Requires non-heme-iron(II). Isolated from some bacteria including Streptomyces hygroscopicus and Streptomyces viridochromogenes. The pro-R hydrogen at C-2 of the ethyl group is retained by the formate ion. Any stereochemistry at C-1 of the ethyl group is lost. One atom from dioxygen is present in each product. Involved in phosphinothricin biosynthesis.
History EC 1.13.11.72 created 2012
Pathway ec00440 Phosphonate and phosphinate metabolism
ec01110 Biosynthesis of secondary metabolites
Orthology K12905 2-hydroxyethylphosphonate dioxygenase
Reference Authors Cicchillo RM, Zhang H, Blodgett JA, Whitteck JT, Li G, Nair SK, van der Donk WA, Metcalf WW
Title An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis.
Journal Sequence Reference Authors Whitteck JT, Malova P, Peck SC, Cicchillo RM, Hammerschmidt F, van der Donk WA
Title On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase.
Journal Reference Authors Peck SC, Cooke HA, Cicchillo RM, Malova P, Hammerschmidt F, Nair SK, van der Donk WA
Title Mechanism and substrate recognition of 2-hydroxyethylphosphonate dioxygenase.
Journal Sequence Other DBs
