| Entry |
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| Name |
2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming);
phnZ (gene name)
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| Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
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| Sysname |
2-amino-1-hydroxyethylphosphonate:oxygen 1-oxidoreductase (glycine-forming)
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| Reaction(IUBMB) |
(2-amino-1-hydroxyethyl)phosphonate + O2 = glycine + phosphate [RN: R10722]
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| Reaction(KEGG) |
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| Substrate |
(2-amino-1-hydroxyethyl)phosphonate [CPD: C05678];
O2 [CPD: C00007]
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| Product |
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| Comment |
Requires Fe2+. The enzyme, characterized from a marine bacterium, is involved in a 2-aminoethylphosphonate degradation pathway.
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| History |
EC 1.13.11.78 created 2014
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| Pathway |
| ec00440 | Phosphonate and phosphinate metabolism |
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| Orthology |
| K05915 | (hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase |
| K21196 | 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming) |
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| Genes |
| SSCK: | SPSK_02742 SPSK_09841 |
| PLJ: | VFPFJ_04692 VFPFJ_10444 |
| ZTR: | MYCGRDRAFT_104600 MYCGRDRAFT_96870 |
| BCOM: | BAUCODRAFT_309643 BAUCODRAFT_37034 |
| ACAN: | ACA1_131370 ACA1_196720 |
| SMIN: | v1.2.002470.t1(symbB.v1.2.002470.t1) |
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| Reference |
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| Authors |
McSorley FR, Wyatt PB, Martinez A, DeLong EF, Hove-Jensen B, Zechel DL |
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| Title |
PhnY and PhnZ comprise a new oxidative pathway for enzymatic cleavage of a carbon-phosphorus bond. |
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| Journal |
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| Reference |
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| Authors |
Worsdorfer B, Lingaraju M, Yennawar NH, Boal AK, Krebs C, Bollinger JM Jr, Pandelia ME |
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| Title |
Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases. |
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| Journal |
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| Sequence |
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| Other DBs |
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