| Entry |
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| Name |
5-aminosalicylate 1,2-dioxygenase;
mabB (gene name)
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| Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
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| Sysname |
5-aminosalicylate:oxygen 1,2-oxidoreductase (ring-opening)
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| Reaction(IUBMB) |
5-aminosalicylate + O2 = (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate [RN: R12147]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
(2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate [CPD: C21928]
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| Comment |
Requires iron(II). The enzyme, characterized from different bacteria, is a nonheme iron dioxygenase in the bicupin family.
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| History |
EC 1.13.11.86 created 2018
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| Orthology |
| K23019 | 5-aminosalicylate 1,2-dioxygenase |
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| Reference |
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| Authors |
Stolz A, Nortemann B, Knackmuss HJ |
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| Title |
Bacterial metabolism of 5-aminosalicylic acid. Initial ring cleavage. |
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| Journal |
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| Reference |
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| Authors |
Yu H, Zhao S, Guo L |
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| Title |
Novel Gene Encoding 5-Aminosalicylate 1,2-Dioxygenase from Comamonas sp. Strain QT12 and Catalytic Properties of the Purified Enzyme. |
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| Journal |
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| Sequence |
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| Other DBs |
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