KEGG   ENZYME: 1.13.11.89
Entry
EC 1.13.11.89               Enzyme                                 
Name
(hydroxymethyl)phosphonate dioxygenase;
phnZ1 (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
(hydroxymethyl)phosphonate:oxygen 1-oxidoreductase (formate-forming)
Reaction(IUBMB)
(hydroxymethyl)phosphonate + O2 = formate + phosphate [RN:R12451]
Reaction(KEGG)
R12451
Substrate
hydroxymethylphosphonate [CPD:C06455];
O2 [CPD:C00007]
Product
formate [CPD:C00058];
phosphate [CPD:C00009]
Comment
Requires iron(II). The enzyme, characterized from the marine bacterium Gimesia maris, participates in a methylphosphonate degradation pathway. It also has the activity of EC 1.13.11.78, (2-amino-1-hydroxyethyl)phosphonate dioxygenase (glycine-forming).
History
EC 1.13.11.89 created 2019
Pathway
ec00440  Phosphonate and phosphinate metabolism
Orthology
K05915  (hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase
Genes
GMR: GmarT_03180
Reference
1  [PMID:30810303]
  Authors
Gama SR, Vogt M, Kalina T, Hupp K, Hammerschmidt F, Pallitsch K, Zechel DL
  Title
An Oxidative Pathway for Microbial Utilization of Methylphosphonic Acid as a Phosphate Source.
  Journal
ACS Chem Biol 14:735-741 (2019)
DOI:10.1021/acschembio.9b00024
  Sequence
[gmr:GmarT_03180]
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.89
IUBMB Enzyme Nomenclature: 1.13.11.89
ExPASy - ENZYME nomenclature database: 1.13.11.89
BRENDA, the Enzyme Database: 1.13.11.89

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (2)   
   InterPro (2)   
All databases (14)   

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