KEGG ENZYME: 1.13.11.90

ENZYME: 1.13.11.90

Entry

EC 1.13.11.90               Enzyme

Name

[1-hydroxy-2-(trimethylamino)ethyl]phosphonate dioxygenase (glycine-betaine-forming);
tmpB (gene name)

Class

Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen

Sysname

[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate:oxygen 1R-oxidoreductase (glycine-betaine-forming)

Reaction(IUBMB)

[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 = glycine betaine + phosphate [RN:R12614]

Reaction(KEGG)

R12614

Substrate

[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate [CPD:C22271];
O2 [CPD:C00007]

Product

glycine betaine [CPD:C00719];
phosphate [CPD:C00009]

Comment

Requires Fe2+. This bacterial enzyme is involved in a degradation pathway for [2-(trimethylamino)ethyl]phosphonate.

History

EC 1.13.11.90 created 2020

Orthology

K24290

[1-hydroxy-2-(trimethylamino)ethyl]phosphonate dioxygenase

Genes

DCS:	ISN74_05310

MARJ:

MARI_16710

MOQ:	HWV03_17255

HAF:	C8233_04170

HPIS:

P1P91_13955

CAMH:

LCW13_07220

COBE:

CLAM6_13460

MARS:

A8C75_09135

MRZ:	KDW95_08525

TSN:	W908_07690

THIN:

CRN91_02450

PMEG:

FNZ07_29580

PPAI:

E1956_08230

MLO:

mll1439

MLN:	A9174_18905

MCI:	Mesci_3238

MCIC:

A4R28_10580

MOP:	Mesop_3630

MAM:	Mesau_03503

MAMO:

A6B35_22565

MESW:

A9K65_017535

MESP:

C1M53_13020

MHUA:

MCHK_3076

MJR:	EB229_19190

MERD:

EB233_16535

MOH:	IHQ72_17270

HOE:	IMCC20628_01349

PHYL:

HB779_23155

RLS:	HB780_09250

LNE:	FZC33_24915

NOH:	G5V57_30910

LABR:

CHH27_03685

LABP:

FJ695_19970

SIL:

SPO3381

SIT:	TM1040_0334

RUA:	D1823_16310

RUT:	FIU92_15155

RCON:

K3740_16495

PGA:	PGA1_c27210

PGL:	PGA2_c25230

PGD:

Gal_00706

PHP:	PhaeoP97_02667

PPIC:

PhaeoP14_02469

PHQ:	D1820_08320

OCT:	FTO60_03575

LMD:	METH_08245

LEJ:	ETW24_09555

LAQU:

R2C4_08475

LEV:	ETW23_09415

LCAE:

K3721_08725

SULZ:

C1J03_21465

SULI:

C1J05_15875

ROM:	EI983_17980

RPEL:

N7U68_11420

TSCO:

R1T40_13875

SEDI:

EBB79_01650

PPSO:

QPJ95_14620

PSEB:

EOK75_16315

PAED:

G5B38_12535

CACT:

HZ995_05370

ACRO:

K3J57_14490

AMYL:

QBD29_06790

SKT:	IGS68_25165

SNEA:

NBZ79_11450

PARH:

I5S86_23675

SOV:	QZH56_01015

AHEL:

Q31a_61960

AAGG:

ETAA8_30030

AMUC:

Pan181_49250

PND:	Pla175_29170

GPN:	Pan110_01650

TSPH:

KIH39_14755

COY:	HF329_07175

» show all

Reference

1 [PMID:30789718]

Authors

Rajakovich LJ, Pandelia ME, Mitchell AJ, Chang WC, Zhang B, Boal AK, Krebs C, Bollinger JM Jr

Title

A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases.

Journal

Biochemistry 58:1627-1647 (2019)
DOI:10.1021/acs.biochem.9b00044

Sequence

[ag:WP_027237573]

Other DBs

ExplorEnz - The Enzyme Database:

1.13.11.90

IUBMB Enzyme Nomenclature:

1.13.11.90

ExPASy - ENZYME nomenclature database:

1.13.11.90

BRENDA, the Enzyme Database:

1.13.11.90

All links

Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (795)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (74)   
   KEGG MGENES (720)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (3)   
   InterPro (3)   
All databases (805)   

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