KEGG ENZYME: 1.13.12.18

ENZYME: 1.13.12.18

Entry

EC 1.13.12.18               Enzyme

Name

dinoflagellate luciferase;
(dinoflagellate luciferin) luciferase;
Gonyaulax luciferase

Class

Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)

Sysname

dinoflagellate-luciferin:oxygen 132-oxidoreductase

Reaction(IUBMB)

dinoflagellate luciferin + O2 = oxidized dinoflagellate luciferin + H2O + hnu [RN:R09571]

Reaction(KEGG)

R09571

Substrate

dinoflagellate luciferin [CPD:C19704];
O2 [CPD:C00007]

Product

oxidized dinoflagellate luciferin [CPD:C19705];
H2O [CPD:C00001];
hnu [CPD:C00205]

Comment

A luciferase from dinoflagellates such as Gonyaulax polyedra, Lingulodinium polyedrum, Noctiluca scintillans, and Pyrocystis lunula. It is a single protein with three luciferase domains. The luciferin is strongly bound by a luciferin binding protein above a pH of 7.

History

EC 1.13.12.18 created 2011

Orthology

K22500

dinoflagellate luciferase

Reference

1 [PMID:7197271]

Authors

Dunlap JC, Hastings JW

Title

The biological clock in Gonyaulax controls luciferase activity by regulating turnover.

Journal

J Biol Chem 256:10509-18 (1981)

Reference

2 [PMID:2745419]

Authors

Morse D, Pappenheimer AM Jr, Hastings JW

Title

Role of a luciferin-binding protein in the circadian bioluminescent reaction of Gonyaulax polyedra.

Journal

J Biol Chem 264:11822-6 (1989)

Reference

3 [PMID:7918642]

Authors

Bae YM, Hastings JW

Title

Cloning, sequencing and expression of dinoflagellate luciferase DNA from a marine alga, Gonyaulax polyedra.

Journal

Biochim Biophys Acta 1219:449-56 (1994)
DOI:10.1016/0167-4781(94)90071-X

Sequence

[ag:AAC36472]

Reference

4 [PMID:10812605]

Authors

Li L

Title

Gonyaulax luciferase: gene structure, protein expression, and purification from recombinant sources.

Journal

Methods Enzymol 305:249-58 (2000)
DOI:10.1016/s0076-6879(00)05492-6

Reference

5 [PMID:10812606]

Authors

Morse D, Mittag M

Title

Dinoflagellate luciferin-binding protein.

Journal

Methods Enzymol 305:258-76 (2000)
DOI:10.1016/s0076-6879(00)05493-8

Reference

6 [PMID:15665092]

Authors

Schultz LW, Liu L, Cegielski M, Hastings JW

Title

Crystal structure of a pH-regulated luciferase catalyzing the bioluminescent oxidation of an open tetrapyrrole.

Journal

Proc Natl Acad Sci U S A 102:1378-83 (2005)
DOI:10.1073/pnas.0409335102

Other DBs

ExplorEnz - The Enzyme Database:

1.13.12.18

IUBMB Enzyme Nomenclature:

1.13.12.18

ExPASy - ENZYME nomenclature database:

1.13.12.18

BRENDA, the Enzyme Database:

1.13.12.18

CAS:	303183-71-3

All links

Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (38)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (36)   
Protein sequence (8)   
   UniProt (7)   
   SWISS-PROT (1)   
DNA sequence (16)   
   GenBank (8)   
   EMBL (8)   
Protein domain (6)   
   InterPro (6)   
All databases (75)   

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