KEGG ENZYME: 1.13.12.21

ENZYME: 1.13.12.21

Entry

EC 1.13.12.21               Enzyme

Name

tetracenomycin-F1 monooxygenase;
tcmH (gene name)

Class

Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)

Sysname

tetracenomycin-F1:oxygen C5-monooxygenase

Reaction(IUBMB)

tetracenomycin F1 + O2 = tetracenomycin D3 + H2O [RN:R06700]

Reaction(KEGG)

R06700

Substrate

tetracenomycin F1 [CPD:C12367];
O2 [CPD:C00007]

Product

tetracenomycin D3 [CPD:C12368];
H2O [CPD:C00001]

Comment

The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens.

History

EC 1.13.12.21 created 2013

Pathway

ec01057

Biosynthesis of type II polyketide products

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K15969

tetracenomycin F1 monooxygenase

Genes

SGU:	SGLAU_26340(tcmH)

Reference

1 [PMID:8329392]

Authors

Shen B, Hutchinson CR

Title

Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.

Journal

Biochemistry 32:6656-63 (1993)
DOI:10.1021/bi00077a019

Other DBs

ExplorEnz - The Enzyme Database:

1.13.12.21

IUBMB Enzyme Nomenclature:

1.13.12.21

ExPASy - ENZYME nomenclature database:

1.13.12.21

BRENDA, the Enzyme Database:

1.13.12.21

DBGET integrated database retrieval system