KEGG ENZYME: 1.13.12.23

ENZYME: 1.13.12.23

Entry

EC 1.13.12.23               Enzyme

Name

4-hydroxy-3-prenylbenzoate synthase;
CloR;
novR (gene name)

Class

Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)

Sysname

4-hydroxy-3-prenylmandelate:oxygen oxidoreductase (4-hydroxy-3-prenylbenzoate forming)

Reaction(IUBMB)

4-hydroxy-3-prenylmandelate + O2 = 4-hydroxy-3-prenylbenzoate + CO2 + H2O [RN:R06759]

Reaction(KEGG)

R06759

Substrate

4-hydroxy-3-prenylmandelate [CPD:C12457];
O2 [CPD:C00007]

Product

4-hydroxy-3-prenylbenzoate [CPD:C12458];
CO2 [CPD:C00011];
H2O [CPD:C00001]

Comment

Isolated from the bacterium Streptomyces roseochromogenes DS 12976. A bifunctional enzyme involved in clorobiocin biosynthesis that also catalyses the activity of EC 1.13.11.83, 4-hydroxy-3-prenylphenylpyruvate oxygenase.

History

EC 1.13.12.23 created 2017

Pathway

ec00401

Novobiocin biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K12708

4-hydroxy-3-prenylphenylpyruvate oxygenase / 4-hydroxy-3-prenylbenzoate synthase

Genes