Entry
Name
tryptophan 2'-dioxygenase;
indole-3-alkane alpha-hydroxylase;
tryptophan side-chain alpha,beta-oxidase;
tryptophan side chain oxidase II;
tryptophan side-chain oxidase;
TSO;
indolyl-3-alkan alpha-hydroxylase;
tryptophan side chain oxidase type I;
TSO I ;
TSO II;
tryptophan side chain oxidase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
Miscellaneous
BRITE hierarchy
Sysname
L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)
Reaction(IUBMB)
L-tryptophan + O2 = (indol-3-yl)glycolaldehyde + CO2 + NH3 [RN:
R00681 ]
Reaction(KEGG)
Substrate
Product
Comment
A hemoprotein. Acts on a number of indole-3-alkane derivatives, oxidizing the 3-side-chain in the 2'-position. Best substrates were L-tryptophan and 5-hydroxy-L-tryptophan.
History
EC 1.13.99.3 created 1984
Pathway
Reference
Authors
Roberts J, Rosenfeld HJ.
Title
Isolation, crystallization, and properties of indolyl-3-alkane alpha-hydroxylase. A novel tryptophan-metabolizing enzyme.
Journal
J Biol Chem 252:2640-7 (1977)
Reference
Authors
Takai K, Ushiro H, Noda Y, Narumiya S, Tokuyama T.
Title
Crystalline hemoprotein from Pseudomonas that catalyzes oxidation of side chain of tryptophan and other indole derivatives.
Journal
J Biol Chem 252:2648-56 (1977)
Other DBs
ExPASy - ENZYME nomenclature database: 1.13.99.3