KEGG ENZYME: 1.14.11.11

ENZYME: 1.14.11.11

Entry

EC 1.14.11.11               Enzyme

Name

hyoscyamine (6S)-dioxygenase;
hyoscyamine 6beta-hydroxylase;
hyoscyamine 6beta-dioxygenase;
hyoscyamine 6-hydroxylase

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

Sysname

L-hyoscyamine,2-oxoglutarate:oxygen oxidoreductase [(6S)-hydroxylating]

Reaction(IUBMB)

L-hyoscyamine + 2-oxoglutarate + O2 = (6S)-hydroxyhyoscyamine + succinate + CO2 [RN:R03812]

Reaction(KEGG)

R03812

Substrate

L-hyoscyamine [CPD:C02046];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]

Product

(6S)-hydroxyhyoscyamine [CPD:C03325];
succinate [CPD:C00042];
CO2 [CPD:C00011]

Comment

Requires Fe2+ and ascorbate.

History

EC 1.14.11.11 created 1989

Pathway

ec00960

Tropane, piperidine and pyridine alkaloid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K12692

hyoscyamine (6S)-dioxygenase / 6beta-hydroxyhyoscyamine epoxidase

Reference

1 [PMID:16664866]

Authors

Hashimoto T, Yamada Y.

Title

Hyoscyamine 6beta-Hydroxylase, a 2-Oxoglutarate-Dependent Dioxygenase, in Alkaloid-Producing Root Cultures.

Journal

Plant Physiol 81:619-625 (1986)
DOI:10.1104/pp.81.2.619

Other DBs

ExplorEnz - The Enzyme Database:

1.14.11.11

IUBMB Enzyme Nomenclature:

1.14.11.11

ExPASy - ENZYME nomenclature database:

1.14.11.11

BRENDA, the Enzyme Database:

1.14.11.11

CAS:	103865-33-4

DBGET integrated database retrieval system