KEGG ENZYME: 1.14.11.32

ENZYME: 1.14.11.32

Entry

EC 1.14.11.32               Enzyme

Name

codeine 3-O-demethylase;
codeine O-demethylase;
CODM

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

Sysname

codeine,2-oxoglutarate:oxygen oxidoreductase (3-O-demethylating)

Reaction(IUBMB)

codeine + 2-oxoglutarate + O2 = morphine + formaldehyde + succinate + CO2 [RN:R09402]

Reaction(KEGG)

R09402;
(other) R05127

Substrate

codeine [CPD:C06174];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]

Product

morphine [CPD:C01516];
formaldehyde [CPD:C00067];
succinate [CPD:C00042];
CO2 [CPD:C00011]

Comment

Requires Fe2+. Catalyses a step in morphine biosynthesis. The enzyme also catalyses the 3-O-demethylation of thebaine to oripavine, with lower efficiency.

History

EC 1.14.11.32 created 2010

Pathway

ec00950

Isoquinoline alkaloid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K14975

codeine 3-O-demethylase