KEGG ENZYME: 1.14.11.40

ENZYME: 1.14.11.40

Entry

EC 1.14.11.40               Enzyme

Name

enduracididine beta-hydroxylase;
MppO;
L-enduracididine,2-oxoglutarate:O2 oxidoreductase (3-hydroxylating)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

Sysname

L-enduracididine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)

Reaction(IUBMB)

L-enduracididine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-enduracididine + succinate + CO2 [RN:R10413]

Reaction(KEGG)

R10413

Substrate

L-enduracididine [CPD:C20602];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]

Product

(3S)-3-hydroxy-L-enduracididine [CPD:C20603];
succinate [CPD:C00042];
CO2 [CPD:C00011]

Comment

Fe2+-dependent enzyme. The enzyme is involved in biosynthesis of the nonproteinogenic amino acid beta-hydroxyenduracididine, a component of the mannopeptimycins (cyclic glycopeptide antibiotic), produced by Streptomyces hygroscopicus NRRL 30439.

History

EC 1.14.11.40 created 2013

Orthology

K20157

enduracididine beta-hydroxylase

Genes

PMAZ:

R5H13_00650(gntD)

PAEW:

KIH87_10705 KIH87_10710

PMAH:

PTQ21_29020(gntD)

SANL:

KZO11_33155

SLC:	SL103_33940

STRO:

STRMOE7_21380

SCHF:

IPT68_29035(vioC)

SMOB:

J7W19_00465

SINE:

KI385_25385

SRUG:

F0345_13160 F0345_18305

SVIO:

HWN34_05600 HWN34_12490

SCIR:

STRCI_008010

SXT:	KPP03845_105564

STEE:

F3L20_32770

SANT:

QR300_02945(vioC)

SFIY:

F0344_15590 F0344_25995

SHAU:

K9S39_20875

SCOA:

QU709_45565(gntD)

KBU:	Q4V64_42065(gntD)

MPRN:

Q3V37_15020(vioC)

DVC:	Dvina_20415

DFU:	Dfulv_06250

DROS:

Drose_05520

GML:	ISF26_10190

STOQ:

K2F26_16470(gntD)

SCOR:

J3U87_31550

COY:	HF329_04825

CSAC:

SIO70_21980

SINH:

LS482_06855

CHRJ:

CHRYMOREF3P_0460

CORA:

N0B40_06105

» show all

Reference

1 [PMID:16298295]

Authors

Haltli B, Tan Y, Magarvey NA, Wagenaar M, Yin X, Greenstein M, Hucul JA, Zabriskie TM

Title

Investigating beta-hydroxyenduracididine formation in the biosynthesis of the mannopeptimycins.

Journal

Chem Biol 12:1163-8 (2005)
DOI:10.1016/j.chembiol.2005.09.013

Sequence

[ag:AAU34208]

Reference

2 [PMID:16723579]

Authors

Magarvey NA, Haltli B, He M, Greenstein M, Hucul JA

Title

Biosynthetic pathway for mannopeptimycins, lipoglycopeptide antibiotics active against drug-resistant gram-positive pathogens.

Journal

Antimicrob Agents Chemother 50:2167-77 (2006)
DOI:10.1128/AAC.01545-05

Sequence

[ag:AAU34208]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.11.40

IUBMB Enzyme Nomenclature:

1.14.11.40

ExPASy - ENZYME nomenclature database:

1.14.11.40

BRENDA, the Enzyme Database:

1.14.11.40

All links

Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (37)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (36)   
Protein sequence (26)   
   UniProt (25)   
   SWISS-PROT (1)   
DNA sequence (26)   
   GenBank (13)   
   EMBL (13)   
Protein domain (5)   
   InterPro (5)   
All databases (102)   

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