KEGG ENZYME: 1.14.11.41

ENZYME: 1.14.11.41

Entry

EC 1.14.11.41               Enzyme

Name

L-arginine hydroxylase;
VioC (ambiguous);
L-arginine,2-oxoglutarate:O2 oxidoreductase (3-hydroxylating)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

Sysname

L-arginine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)

Reaction(IUBMB)

L-arginine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-arginine + succinate + CO2 [RN:R09363]

Reaction(KEGG)

R09363

Substrate

L-arginine [CPD:C00062];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]

Product

(3S)-3-hydroxy-L-arginine [CPD:C18473];
succinate [CPD:C00042];
CO2 [CPD:C00011]

Comment

Fe2+-dependent enzyme. The enzyme is involved in the biosynthesis of the cyclic pentapeptide antibiotic viomycin. It differs from EC 1.14.20.7, 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming), because it does not form guanidine and (S)-1-pyrroline-5-carboxylate from 3-hydroxy-L-arginine.

History

EC 1.14.11.41 created 2013

Orthology

K20612

L-arginine hydroxylase

Genes

SCAL:

I6J39_31740(vioC)

Reference

1 [PMID:15368582]

Authors

Ju J, Ozanick SG, Shen B, Thomas MG