KEGG ENZYME: 1.14.11.46

ENZYME: 1.14.11.46

Entry

EC 1.14.11.46               Enzyme

Name

2-aminoethylphosphonate dioxygenase;
phnY (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

Sysname

(2-aminoethyl)phosphonate,2-oxoglutarate:oxygen oxidoreductase (1-hydroxylating)

Reaction(IUBMB)

(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 = (2-amino-1-hydroxyethyl)phosphonate + succinate + CO2 [RN:R10724]

Reaction(KEGG)

R10724

Substrate

(2-aminoethyl)phosphonate [CPD:C03557];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]

Product

(2-amino-1-hydroxyethyl)phosphonate [CPD:C05678];
succinate [CPD:C00042];
CO2 [CPD:C00011]

Comment

Requires Fe2+ and ascorbate. The enzyme, characterized from an uncultured marine bacterium, is involved in a (2-aminoethyl)phosphonate degradation pathway.

History

EC 1.14.11.46 created 2014

Pathway

ec00440

Phosphonate and phosphinate metabolism

ec01100

Metabolic pathways

Orthology

K21195

2-aminoethylphosphonate dioxygenase

Genes

HSY:

130647361

SSCK:

SPSK_09539

FVR:	FVEG_07745

FOX:	FOXG_04606

FMU:	J7337_010235

MAW:

MAC_01242

MAJ:

MAA_09259

PCHM:

VFPPC_10562

AMUS:

LMH87_001948 LMH87_002500

PLJ:	VFPFJ_04691 VFPFJ_10443

PTKZ:

JDV02_002889

BFU:	BCIN_06g00110

PSCO:

LY89DRAFT_740562 LY89DRAFT_780538

NFI:	NFIA_065130

AOR:	AO090003000788

ANG:	An02g08170

AFV:	AFLA_000896

ALUC:

AKAW2_10681S

ACHE:

ACHE_70898S

APUU:

APUU_10043A APUU_21506A APUU_22170A

PCS:	N7525_000653 N7525_005070

TMF:	EYB26_004302

TRG:	TRUGW13939_10951

PFJ:	MYCFIDRAFT_208708

FFU:	CLAFUR5_08687

BCOM:

BAUCODRAFT_150689 BAUCODRAFT_152254

TASA:

A1Q1_05374

CCAC:

CcaHIS019_0503930(CcaverHIS019_0503930)

MPR:	MPER_04257 MPER_08557 MPER_09847

MRR:	Moror_5305

E1B28_010180

ACAN:

ACA1_254860

PTI:	PHATRDRAFT_45928

FCY:	FRACYDRAFT_268105

EHX:	EMIHUDRAFT_205428

SRL:	SOD_c30110

SRY:	M621_16415

XVA:	C7V42_21005

PPZ:	H045_01945

PCUC:

PSH97_03870

LHA:

LHA_1528

LCD:	clem_07265 clem_12590

LLG:	44548918_01853

LCJ:	NCTC11976_01454

FHA:	CDV26_02635

NOC:

Noc_1391

NHL:

Nhal_1353

NWA:

Nwat_1690

NJP:	NEJAP_2516

BOK:

DM82_2522

BOC:

BG90_2211

BSAV:

WS86_03975

BPLA:

bpln_2g04930

BCAI:

K788_00002425

PBRY:

NDK50_34995

CPRA:

CPter91_0286

MLO:

mlr5924

MLN:	A9174_32400

MAMO:

A6B35_30635

MJR:	EB229_33120

MERD:

EB233_30770

MOH:	IHQ72_34060

AMIS:

Amn_11160

REC:	RHECIAT_PB0000354

REP:	IE4803_PB00468

RHN:	AMJ98_PC00366

RPHA:

AMC79_PC00337

RHX:	AMK02_PC00355

RHK:	Kim5_PA00463

REZ:	AMJ99_PB00360

ARA:

Arad_7878

BJA:	blr2133(blr2133)

BJU:	BJ6T_77170

BJP:	RN69_37475

BRC:	BCCGELA001_30190

BBAN:

J4G43_043220

BXN:	I3J27_33220

SXA:	FMM02_04075

RGI:	RGI145_09800

ROS:	CTJ15_07630

RMUC:

FOB66_09655

LCK:	HN018_01530

HTQ:	FRZ44_48830

HADH:

FRZ61_47170

ECOG:

FIV45_14930

PSWU:

SY83_09970

MMAM:

K3U93_12405

SLIA:

HA039_16970

NPS:	KRR39_01800

FRA:	Francci3_1994

KBU:	Q4V64_21655

AOU:	ACTOB_005088

ABAI:

IMCC26256_11466

AYM:	YM304_40490

AQZ:	KSP35_12360

SYND:

KR52_11175

PMF:	P9303_11261

PMG:	P9301_12551

RCS:	NIES932_28410

TOQ:	HCG51_21855

NCN:	BZZ01_05245

SNG:	SNE_A16380

PIR:	VN12_13835

LCRE:

Pla8534_05960

PLS:	VT03_21420

GPN:	Pan110_03670

GFM:	Enr17x_03140

LRS:	PX52LOC_01454

TSPH:

KIH39_09740 KIH39_13710

PGO:	FSB84_15750

PCM:	AY601_0443

PGJ:	QG516_04660

RCG:	N7E81_15235

» show all

Reference

1 [PMID:22564006]

Authors

McSorley FR, Wyatt PB, Martinez A, DeLong EF, Hove-Jensen B, Zechel DL

Title

PhnY and PhnZ comprise a new oxidative pathway for enzymatic cleavage of a carbon-phosphorus bond.

Journal

J Am Chem Soc 134:8364-7 (2012)
DOI:10.1021/ja302072f

Other DBs

ExplorEnz - The Enzyme Database:

1.14.11.46

IUBMB Enzyme Nomenclature:

1.14.11.46

ExPASy - ENZYME nomenclature database:

1.14.11.46

BRENDA, the Enzyme Database:

1.14.11.46

DBGET integrated database retrieval system