KEGG   ENZYME: 1.14.11.48
Entry
EC 1.14.11.48               Enzyme                                 
Name
xanthine dioxygenase;
XanA;
alpha-ketoglutarate-dependent xanthine hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
xanthine,2-oxoglutarate:oxygen oxidoreductase
Reaction(IUBMB)
xanthine + 2-oxoglutarate + O2 = urate + succinate + CO2 [RN:R10920]
Reaction(KEGG)
R10920
Substrate
xanthine [CPD:C00385];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
urate [CPD:C00366];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and L-ascorbate. The enzyme, which was characterized from fungi, is specific for xanthine.
History
EC 1.14.11.48 created 2015
Orthology
K23516  xanthine dioxygenase
Genes
APRO: F751_4638
KLA: KLLA0_E04357g
KMX: KLMA_20520
LTH: KLTH0A03674g
ZRO: ZYRO0D16324g
TGB: HG536_0C04630
TDL: TDEL_0H02320(TDEL0H02320)
ZMK: HG535_0F03460
PPA: PAS_chr3_0332
DHA: DEHA2A01518g
PIC: PICST_34838
PGU: PGUG_04939
SPAA: SPAPADRAFT_60857
LEL: PVL30_001093
CAL: CAALFM_C201540WA(CaO19.1461)
CTP: CTRG_01245
COT: CORT_0A13470
CDU: CD36_16390
CTEN: CANTEDRAFT_112698
YLI: YALI0A06974g
CLU: CLUG_03270
CLUS: A9F13_01g09218
CAUR: CJI96_0002396
SLB: AWJ20_5294
PKZ: C5L36_0E04300
BNN: FOA43_002239
BBRX: BRETT_005011
OPA: HPODL_02648
SLUD: SCDLUD_000378
NCR: NCU09738
NTE: NEUTE1DRAFT78605(NEUTE1DRAFT_78605)
SMP: SMAC_04772
PAN: PODANSg7245
PBEL: QC761_602860(XAN1)
PPSD: QC762_602860(XAN1)
PPSP: QC763_602860(XAN1)
PPSA: QC764_602860(XAN1)
PGRI: PgNI_08720 PgNI_11652
TMN: UCRPA7_562 UCRPA7_8167 UCRPA7_8169
SSCK: SPSK_05310 SPSK_05319 SPSK_07553
FGR: FGSG_02692
FPU: FPSE_00399
FPOA: FPOAC1_002821(XAN1)
FVN: FVRRES_03136
FVR: FVEG_09012
FOX: FOXG_10360
NHE: NECHADRAFT_94403
FFC: NCS54_00820500
FKR: NCS57_00863700
FMU: J7337_005382(XAN1)
TRE: TRIREDRAFT_77767
TRR: M419DRAFT_35772
AMUS: LMH87_008517
VAL: VDBG_04614
VDA: VDAG_04163
CFJ: CFIO01_07110 CFIO01_12421 CFIO01_12422
CLUP: CLUP02_14577 CLUP02_14578 CLUP02_15960
CHIG: CH63R_11300 CH63R_12258 CH63R_12321
SAPO: SAPIO_CDS0323
ELA: UCREL1_10403 UCREL1_10408 UCREL1_2937
PFY: PFICI_02622 PFICI_03917 PFICI_03927 PFICI_11089 PFICI_11090
SSL: SS1G_04722
BFU: BCIN_01g08370
PSCO: LY89DRAFT_455914 LY89DRAFT_461846 LY89DRAFT_579972 LY89DRAFT_679151 LY89DRAFT_683826 LY89DRAFT_712245
GLZ: GLAREA_11001
ANI: ANIA_10081
ACT: ACLA_066400
AOR: AO090001000152
ANG: An01g14680
AFV: AFLA_008496
ALUC: AKAW2_20050A
ACHE: ACHE_70909A
APUU: APUU_11553A
PCS: N7525_007948
PDP: PDIP_55050
POU: POX_b01952
TMF: EYB26_003731 EYB26_003733 EYB26_009981
TRG: TRUGW13939_04711 TRUGW13939_11977 TRUGW13939_11979
PTE: PTT_11857 PTT_11858
BZE: COCCADRAFT_32934 COCCADRAFT_9324
BSC: COCSADRAFT_81895
BOR: COCMIDRAFT_8838 COCMIDRAFT_90268
AALT: CC77DRAFT_1029939 CC77DRAFT_1091742 CC77DRAFT_282647 CC77DRAFT_956058
ARAB: EKO05_0009821
PFJ: MYCFIDRAFT_132918 MYCFIDRAFT_191119 MYCFIDRAFT_204269 MYCFIDRAFT_210878 MYCFIDRAFT_4952
FFU: CLAFUR5_06013
BCOM: BAUCODRAFT_464815 BAUCODRAFT_70747
NPA: UCRNP2_604 UCRNP2_605 UCRNP2_67 UCRNP2_9547
SPO: SPCC576.01c
SOM: SOMG_04881(xan1)
CNE: CNC06420
CNB: CNBC0790
CNG: CNAG_01542
CGI: CGB_C1100C
CDEU: CNBG_3894
TMS: TREMEDRAFT_26085
TASA: A1Q1_00018
CCAC: CcaHIS019_0109030(CcaverHIS019_0109030)
TVS: TRAVEDRAFT_67834
DSQ: DICSQDRAFT_96760
PCO: PHACADRAFT_248632
SHS: STEHIDRAFT_101392 STEHIDRAFT_170594
PSQ: PUNSTDRAFT_117809
ADL: AURDEDRAFT_79471
FME: FOMMEDRAFT_143156 FOMMEDRAFT_23586
GTR: GLOTRDRAFT_102027 GLOTRDRAFT_134924
RSX: RhiXN_09780
LBC: LACBIDRAFT_181264 LACBIDRAFT_227808 LACBIDRAFT_242796 LACBIDRAFT_301478
CCI: CC1G_00598 CC1G_00658
ABP: AGABI1DRAFT67631(AGABI1DRAFT_67631)
ABV: AGABI2DRAFT196515(AGABI2DRAFT_196515)
PCUB: JR316_0000256 JR316_0000260 JR316_0012159
MPR: MPER_00967
MRR: Moror_11000 Moror_1739
MORE: E1B28_001800
SCM: SCHCO_02505277(SCHCODRAFT_02505277)
CPUT: CONPUDRAFT_79364 CONPUDRAFT_79365
SLA: SERLADRAFT_480389
WSE: WALSEDRAFT_31174
UMA: UMAG_03386
SGRA: EX895_005468
MSYM: MSY001_2908
PGR: PGTG_00897
PTRC: PtA15_17A261
PSTR: Pst134EA_030520
MLR: MELLADRAFT_71644
PIF: PITG_15878
PSOJ: PHYSODRAFT_491326
 » show all
Reference
1  [PMID:15948966]
  Authors
Cultrone A, Scazzocchio C, Rochet M, Montero-Moran G, Drevet C, Fernandez-Martin R
  Title
Convergent evolution of hydroxylation mechanisms in the fungal kingdom: molybdenum cofactor-independent hydroxylation of xanthine via alpha-ketoglutarate-dependent dioxygenases.
  Journal
Mol Microbiol 57:276-90 (2005)
DOI:10.1111/j.1365-2958.2005.04686.x
  Sequence
[ani:ANIA_10081] [ncr:NCU09738] [spo:SPCC576.01c]
Reference
2  [PMID:17429948]
  Authors
Montero-Moran GM, Li M, Rendon-Huerta E, Jourdan F, Lowe DJ, Stumpff-Kane AW, Feig M, Scazzocchio C, Hausinger RP
  Title
Purification and characterization of the FeII- and alpha-ketoglutarate-dependent  xanthine hydroxylase from Aspergillus nidulans.
  Journal
Biochemistry 46:5293-304 (2007)
DOI:10.1021/bi700065h
  Sequence
[ani:ANIA_10081]
Reference
3  [PMID:18036331]
  Authors
Li M, Muller TA, Fraser BA, Hausinger RP
  Title
Characterization of active site variants of xanthine hydroxylase from Aspergillus nidulans.
  Journal
Arch Biochem Biophys 470:44-53 (2008)
DOI:10.1016/j.abb.2007.11.002
  Sequence
[ani:ANIA_10081]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.48
IUBMB Enzyme Nomenclature: 1.14.11.48
ExPASy - ENZYME nomenclature database: 1.14.11.48
BRENDA, the Enzyme Database: 1.14.11.48

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Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (220)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (179)   
   KEGG MGENES (40)   
Protein sequence (8)   
   UniProt (4)   
   SWISS-PROT (4)   
Protein domain (3)   
   InterPro (3)   
All databases (239)   

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