KEGG   ENZYME: 1.14.11.54
Entry
EC 1.14.11.54               Enzyme                                 
Name
mRNA N1-methyladenine demethylase;
ALKBH3
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
mRNA-N1-methyladenine,2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming)
Reaction(IUBMB)
N1-methyladenine in mRNA + 2-oxoglutarate + O2 = adenine in mRNA + formaldehyde + succinate + CO2
Substrate
N1-methyladenine in mRNA;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
adenine in mRNA [CPD:C21844];
formaldehyde [CPD:C00067];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Contains iron(II). Catalyses oxidative demethylation of mRNA N1-methyladenine. The enzyme is also involved in alkylation repair in DNA [2].
History
EC 1.14.11.54 created 2016
Orthology
K10860  mRNA N1-methyladenine demethylase
Genes
HSA: 221120(ALKBH3)
PTR: 741336(ALKBH3)
PPS: 100973808(ALKBH3)
GGO: 101128171(ALKBH3)
PON: 100171823(ALKBH3)
NLE: 100602324(ALKBH3)
HMH: 116476330(ALKBH3)
MCC: 715921(ALKBH3)
MCF: 101925097(ALKBH3)
MTHB: 126935986
MNI: 105471609(ALKBH3)
CSAB: 103237116(ALKBH3)
CATY: 105586836(ALKBH3)
PANU: 101021086(ALKBH3)
TGE: 112607176(ALKBH3)
MLEU: 105554773(ALKBH3)
RRO: 104673889(ALKBH3)
RBB: 108519277(ALKBH3)
TFN: 117079980(ALKBH3)
PTEH: 111544937(ALKBH3)
CANG: 105527083(ALKBH3)
CJC: 100399955(ALKBH3)
SBQ: 101038261(ALKBH3)
CIMI: 108304911(ALKBH3)
CSYR: 103272130(ALKBH3)
MMUR: 105885533(ALKBH3)
LCAT: 123642614(ALKBH3)
PCOQ: 105819147(ALKBH3)
OGA: 100948961(ALKBH3)
MMU: 69113(Alkbh3)
MCAL: 110284895(Alkbh3)
MPAH: 110318986(Alkbh3)
RNO: 362169(Alkbh3)
MCOC: 116090520(Alkbh3)
ANU: 117704196(Alkbh3)
MUN: 110540590(Alkbh3)
CGE: 100774403(Alkbh3)
MAUA: 101841578(Alkbh3)
PROB: 127222210(Alkbh3)
PLEU: 114699732(Alkbh3)
MORG: 121440554(Alkbh3)
MFOT: 126504682
AAMP: 119814197(Alkbh3)
NGI: 103746670(Alkbh3)
HGL: 101716978(Alkbh3)
CPOC: 100721589(Alkbh3)
CCAN: 109697777(Alkbh3)
DORD: 105996071(Alkbh3)
DSP: 122100744(Alkbh3)
PLOP: 125361836(Alkbh3)
NCAR: 124960109
MMMA: 107135772(Alkbh3)
OCU: 100342939
OPI: 101520863 101530194(ALKBH3)
TUP: 102495653(ALKBH3)
GVR: 103602945(ALKBH3)
CFA: 475938(ALKBH3)
CLUD: 112663517(ALKBH3)
VVP: 112914443(ALKBH3)
VLG: 121501576(ALKBH3)
NPO: 129494106(ALKBH3)
AML: 100483392(ALKBH3)
UMR: 103672347(ALKBH3)
UAH: 113265015(ALKBH3)
UAR: 123799600(ALKBH3)
ELK: 111150166
LLV: 125079412
MPUF: 101674082(ALKBH3)
MNP: 132008213 132008402
MLK: 131811629(ALKBH3)
NVS: 122912859(ALKBH3)
ORO: 101367649(ALKBH3)
EJU: 114215268(ALKBH3)
ZCA: 113913808(ALKBH3)
MLX: 118016268(ALKBH3)
NSU: 110575738(ALKBH3)
LWW: 102747133(ALKBH3)
FCA: 101082850(ALKBH3)
PYU: 121043520(ALKBH3)
PCOO: 112865460(ALKBH3)
PBG: 122483722(ALKBH3)
PVIV: 125176645(ALKBH3)
LRUF: 124505824
PTG: 102963280(ALKBH3)
PPAD: 109279205(ALKBH3)
PUC: 125912836
AJU: 106978053
HHV: 120228413(ALKBH3)
BTA: 514579(ALKBH3)
BOM: 102274694(ALKBH3)
BIU: 109569676(ALKBH3)
BBUB: 102390815(ALKBH3)
BBIS: 105000307(ALKBH3)
CHX: 102187149(ALKBH3)
OAS: 101110359(ALKBH3)
BTAX: 128060163(ALKBH3)
ODA: 120876904(ALKBH3)
CCAD: 122450095(ALKBH3)
MBEZ: 129554769(ALKBH3)
SSC: 100624169(ALKBH3)
CFR: 102515170(ALKBH3)
CBAI: 105076492(ALKBH3)
CDK: 105106833(ALKBH3)
VPC: 102543076(ALKBH3)
BACU: 102998891(ALKBH3)
BMUS: 118900009(ALKBH3)
LVE: 103091564(ALKBH3)
OOR: 101280185(ALKBH3)
DLE: 111184013(ALKBH3)
PCAD: 102977330(ALKBH3)
PSIU: 116757913(ALKBH3)
NASI: 112402140(ALKBH3)
ECB: 100055568(ALKBH3)
EPZ: 103556453(ALKBH3)
EAI: 106843966(ALKBH3)
MYB: 102263934(ALKBH3)
MYD: 107184435(ALKBH3)
MMYO: 118665114(ALKBH3)
MLF: 102422610(ALKBH3)
PKL: 118713577(ALKBH3)
EFUS: 103290864(ALKBH3)
MNA: 107525489(ALKBH3)
DRO: 112303284(ALKBH3)
SHON: 119002962(ALKBH3)
AJM: 119064442(ALKBH3)
PDIC: 114499939(ALKBH3)
PHAS: 123810082(ALKBH3)
MMF: 118627768(ALKBH3)
PPAM: 129081460(ALKBH3)
HAI: 109391971(ALKBH3)
RFQ: 117031275(ALKBH3)
PALE: 102889640(ALKBH3)
PGIG: 120606250(ALKBH3)
PVP: 105289992(ALKBH3)
RAY: 107511889(ALKBH3)
MJV: 108402894(ALKBH3)
TOD: 119255345(ALKBH3)
SARA: 101545936(ALKBH3)
LAV: 100670341(ALKBH3)
TMU: 101348315
ETF: 101653877(ALKBH3)
DNM: 101439626(ALKBH3)
MDO: 100013323(ALKBH3)
GAS: 123251680(ALKBH3)
SHR: 100926516(ALKBH3)
AFZ: 127539676
PCW: 110223980(ALKBH3)
OAA: 100079123(ALKBH3)
GGA: 423169(ALKBH3)
PCOC: 116228989(ALKBH3)
MGP: 100545576(ALKBH3)
CJO: 107314811(ALKBH3)
TPAI: 128086952(ALKBH3)
LMUT: 125695031(ALKBH3)
NMEL: 110402081(ALKBH3)
APLA: 101803990(ALKBH3)
ACYG: 106044148(ALKBH3)
CATA: 118250817(ALKBH3)
AFUL: 116489599(ALKBH3)
TGU: 100220917(ALKBH3)
LSR: 110472035(ALKBH3)
SCAN: 103827001(ALKBH3)
PMOA: 120512571(ALKBH3)
OTC: 121334524(ALKBH3)
PRUF: 121349558(ALKBH3)
GFR: 102039523(ALKBH3)
FAB: 101807443(ALKBH3)
OMA: 130253384(ALKBH3)
PHI: 102106986(ALKBH3)
PMAJ: 107206104(ALKBH3)
CCAE: 111930139(ALKBH3)
CCW: 104688097(ALKBH3)
CBRC: 103620913(ALKBH3)
ETL: 114064859(ALKBH3)
ZAB: 102064160(ALKBH3)
ACHL: 103804349(ALKBH3)
SVG: 106851558(ALKBH3)
MMEA: 130572487(ALKBH3)
HRT: 120754644(ALKBH3)
FPG: 101917358(ALKBH3)
FCH: 102056465(ALKBH3)
CLV: 102087563(ALKBH3)
EGZ: 104134097(ALKBH3)
NNI: 104019570(ALKBH3)
PCRI: 104031898(ALKBH3)
PCAO: 104046663(ALKBH3)
ACUN: 113480635(ALKBH3)
TALA: 104367470(ALKBH3)
PADL: 103921725(ALKBH3)
AFOR: 103897533(ALKBH3)
ACHC: 115334572(ALKBH3)
HALD: 104324275(ALKBH3)
HLE: 104839722(ALKBH3)
AGEN: 126049421
GCL: 127016888
CCRI: 104155532(ALKBH3)
CSTI: 104560638(ALKBH3)
CMAC: 104483325(ALKBH3)
MUI: 104545681(ALKBH3)
BREG: 104640696(ALKBH3)
FGA: 104070497(ALKBH3)
GSTE: 104257560(ALKBH3)
LDI: 104349545(ALKBH3)
OHA: 104330178(ALKBH3)
NNT: 104410311(ALKBH3)
SHAB: 115607336(ALKBH3)
DPUB: 104303048(ALKBH3)
PGUU: 104463662(ALKBH3)
ACAR: 104527082(ALKBH3)
CPEA: 104390445(ALKBH3)
AVIT: 104274782(ALKBH3)
CVF: 104295885(ALKBH3)
RTD: 128908798(ALKBH3)
CUCA: 104067330(ALKBH3)
TEO: 104377610(ALKBH3)
BRHI: 104488160(ALKBH3)
AAM: 106498339(ALKBH3)
AROW: 112978305(ALKBH3)
NPD: 112943532(ALKBH3)
TGT: 104565057(ALKBH3)
DNE: 112979237(ALKBH3)
SCAM: 104149261(ALKBH3)
ASN: 102379536(ALKBH3)
AMJ: 102559132(ALKBH3)
CPOO: 109321369(ALKBH3)
GGN: 109298938(ALKBH3)
PSS: 102446051(ALKBH3)
CMY: 102946097(ALKBH3)
CCAY: 125638498(ALKBH3)
DCC: 119857851(ALKBH3)
CPIC: 101950462(ALKBH3)
TST: 117876979(ALKBH3)
CABI: 116830762(ALKBH3)
MRV: 120404300(ALKBH3)
ACS: 100557858(alkbh3)
ASAO: 132768512(ALKBH3)
PVT: 110081512(ALKBH3)
SUND: 121936322(ALKBH3)
PBI: 103049891(ALKBH3)
PMUR: 107289669(ALKBH3)
CTIG: 120307966(ALKBH3)
TSR: 106545010(ALKBH3)
PGUT: 117665487(ALKBH3)
APRI: 131187431(ALKBH3)
PTEX: 113440762(ALKBH3)
NSS: 113410224(ALKBH3)
VKO: 123026755(ALKBH3)
PMUA: 114596277(ALKBH3)
PRAF: 128413537(ALKBH3)
ZVI: 118085411(ALKBH3)
HCG: 128339352(ALKBH3)
GJA: 107119117(ALKBH3)
STOW: 125425939(ALKBH3)
EMC: 129325315(ALKBH3)
XLA: 496071(alkbh3.L)
XTR: 100495476(alkbh3)
NPR: 108785848(ALKBH3)
RTEM: 120917034(ALKBH3)
BBUF: 120981146(ALKBH3)
BGAR: 122920137(ALKBH3)
MUO: 115468805(ALKBH3)
GSH: 117352284(ALKBH3)
DRE: 792266(alkbh3)
SRX: 107716661
SANH: 107661502 107696266
SGH: 107573924(alkbh3) 107598856
CCAR: 109063459
CAUA: 113043364 113066937(alkbh3)
CGIB: 127946686 128013916
PTET: 122330312(alkbh3)
LROH: 127156747(alkbh3)
OMC: 131534815(alkbh3)
PPRM: 120469201(alkbh3)
RKG: 130104469(alkbh3)
MAMB: 125247648(alkbh3)
CIDE: 127507617
MASI: 127437772
TROS: 130552230(alkbh3)
TDW: 130414571(alkbh3)
MANU: 129433406(alkbh3)
IPU: 100528586(alkbh3)
IFU: 128617854(alkbh3)
PHYP: 113529737(alkbh3)
SMEO: 124392890(alkbh3)
TFD: 113654064(alkbh3)
TVC: 132856867(alkbh3)
AMEX: 103026192(alkbh3)
CMAO: 118811762(alkbh3)
EEE: 113571858(alkbh3)
CHAR: 105913394(alkbh3)
TRU: 101068007(alkbh3)
TFS: 130535909(alkbh3)
TNG: GSTEN00019672G001
LCO: 104922397(alkbh3)
NCC: 104950558
TBEN: 117497258(alkbh3)
CGOB: 115010259(alkbh3)
PGEO: 117448142(alkbh3)
GACU: 117557472(alkbh3)
EMAC: 134883907(alkbh3)
ELY: 117262634(alkbh3)
EFO: 125887888(alkbh3)
PLEP: 121938181 121950266(alkbh3)
SLUC: 116046802(alkbh3)
ECRA: 117948979(alkbh3)
ESP: 116693583(alkbh3)
PFLV: 114560330(alkbh3)
GAT: 120809369(alkbh3)
PPUG: 119196541(alkbh3)
AFB: 129108403(alkbh3)
CLUM: 117731839(alkbh3)
PSWI: 130194941 130195756
MSAM: 119893647(alkbh3)
SCHU: 122874606(alkbh3)
CUD: 121514579(alkbh3)
ALAT: 119024425(alkbh3)
MZE: 101486257(alkbh3)
ONL: 100698973(alkbh3)
OAU: 116313952(alkbh3)
OLA: 101164226(alkbh3)
OML: 112151953(alkbh3)
CSAI: 133443633(alkbh3)
XMA: 102224505(alkbh3)
XCO: 114134553(alkbh3)
XHE: 116710020(alkbh3)
PRET: 103465694(alkbh3)
PFOR: 103152824(alkbh3)
PLAI: 106964818(alkbh3)
PMEI: 106904444(alkbh3)
GAF: 122835862(alkbh3)
PPRL: 129358942(alkbh3)
CVG: 107092180(alkbh3)
CTUL: 119798181(alkbh3)
GMU: 124861177(alkbh3)
NFU: 107374482(alkbh3)
KMR: 108245714(alkbh3)
ALIM: 106529602(alkbh3)
NWH: 119415412(alkbh3)
AOCE: 111567883(alkbh3)
MCEP: 125014327(alkbh3)
CSEM: 103379804(alkbh3)
POV: 109623981(alkbh3)
SSEN: 122775381(alkbh3)
HHIP: 117763684(alkbh3)
HSP: 118110022(alkbh3)
SMAU: 118315693(alkbh3)
LCF: 108889309
SDU: 111229672(alkbh3)
SLAL: 111650456(alkbh3)
XGL: 120793747(alkbh3)
HCQ: 109513176(alkbh3)
SSCV: 125970945
SBIA: 133502085(alkbh3)
PEE: 133403357(alkbh3)
PTAO: 133478263(alkbh3)
BPEC: 110160323(alkbh3)
MALB: 109973531(alkbh3)
BSPL: 114857821(alkbh3)
SJO: 128358313(alkbh3)
SASA: 106561092(alkbh3)
STRU: 115197101(alkbh3)
OTW: 112218280
OMY: 110492083(alkbh3)
OGO: 124039647(alkbh3)
ONE: 115121940 115134525(alkbh3)
OKI: 109867581(alkbh3)
OKE: 118396401(alkbh3)
SALP: 111962104(alkbh3)
SNH: 120066092(alkbh3)
CCLU: 121532127 121540108
ELS: 105006119(alkbh3)
SFM: 108942111(alkbh3)
PKI: 111859477(alkbh3)
AANG: 118215767(alkbh3)
LOC: 102684577(alkbh3)
PSPA: 121330137(alkbh3)
ARUT: 117432411 117434590
PSEX: 120523169(alkbh3)
LCM: 102354734(ALKBH3)
CMK: 103174969(alkbh3)
CPLA: 122557662(alkbh3)
HOC: 132824262(alkbh3)
LERI: 129705678(alkbh3)
PMRN: 116949621(ALKBH3)
LRJ: 133346906(ALKBH3)
BFO: 118408270
BBEL: 109480313
CIN: 100187190
SPU: 592282
LPIC: 129283390
APLC: 110989950
AJC: 117105046
SKO: 102804926
CSCU: 111626499
PTEP: 107437569 122268709
LPOL: 106465920
HRO: HELRODRAFT_185055
LGI: LOTGIDRAFT_133518
PVUL: 126829374
BGT: 106056468
GAE: 121370573
HRF: 124123766
HRJ: 124256624
CRG: 105340036
CVN: 111101457 111101679 111101938
CANU: 128184610
OED: 125672974
MYI: 110457607
PMAX: 117326994
MCAF: 127724249
MMER: 123552565
RPHI: 132743640
DPOL: 127852137
OBI: 106871726
OSN: 115232595
LAK: 106150965 106173692
NVE: 5510799
EPA: 110247701
ATEN: 116301025
XEN: 124446187
HSY: 130655960
 » show all
Reference
1  [PMID:16858410]
  Authors
Sundheim O, Vagbo CB, Bjoras M, Sousa MM, Talstad V, Aas PA, Drablos F, Krokan HE, Tainer JA, Slupphaug G
  Title
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
  Journal
EMBO J 25:3389-97 (2006)
DOI:10.1038/sj.emboj.7601219
  Sequence
[hsa:221120]
Reference
2  [PMID:22055184]
  Authors
Dango S, Mosammaparast N, Sowa ME, Xiong LJ, Wu F, Park K, Rubin M, Gygi S, Harper JW, Shi Y
  Title
DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.
  Journal
Mol Cell 44:373-84 (2011)
DOI:10.1016/j.molcel.2011.08.039
  Sequence
[hsa:221120]
Reference
3  [PMID:26863410]
  Authors
Li X, Xiong X, Wang K, Wang L, Shu X, Ma S, Yi C
  Title
Transcriptome-wide mapping reveals reversible and dynamic N(1)-methyladenosine methylome.
  Journal
Nat Chem Biol 12:311-6 (2016)
DOI:10.1038/nchembio.2040
  Sequence
[hsa:221120]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.54
IUBMB Enzyme Nomenclature: 1.14.11.54
ExPASy - ENZYME nomenclature database: 1.14.11.54
BRENDA, the Enzyme Database: 1.14.11.54

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Gene (2595)   
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   KEGG GENES (434)   
   KEGG MGENES (185)   
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Protein sequence (39)   
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   SWISS-PROT (4)   
   RefSeq(pep) (23)   
DNA sequence (31)   
   RefSeq(nuc) (23)   
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