Entry
Name
ectoine hydroxylase;
ectD (gene name);
ectoine dioxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
ectoine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)
Reaction(IUBMB)
ectoine + 2-oxoglutarate + O2 = 5-hydroxyectoine + succinate + CO2 [RN:
R08050 ]
Reaction(KEGG)
Substrate
Product
Comment
Requires Fe2+ and ascorbate. The enzyme, found in bacteria, is specific for ectoine.
History
EC 1.14.11.55 created 2017
Pathway
ec00260 Glycine, serine and threonine metabolism
Orthology
Genes
MHC : MARHY1452(ectD) MARHY3849(ectD)
HMI : soil367_13195(thpD) soil367_14180(thpD)
HCO : LOKO_00567 LOKO_03086
HALO : BWR19_12730 BWR19_17025
HBE : BEI_0262(ectD1) BEI_2549(ectD2)
HAXI : HAALTHF_18370n(ectD)
HSV : HNO53_14665(thpD) HNO53_19665(thpD)
HALF : QEN58_15820(thpD) QEN58_18675(thpD)
HASH : HXW73_01935(thpD) HXW73_07445(thpD) HXW73_16980(thpD)
HOL : HORIV_56850 HORIV_69520
HNP : SR894_16485(thpD) SR894_21285(thpD)
HTT : HZS52_05815(thpD) HZS52_09840(thpD)
HCAM : I4484_14265(thpD) I4484_19325(thpD)
HSX : HNO51_14005(thpD) HNO51_19405(thpD)
HTX : EKK97_15830(thpD) EKK97_21770(thpD)
ALCA : ASALC70_00238(ectD_1) ASALC70_02515(ectD_2)
BTRM : SAMEA390648704056(thpD_2)
SALE : EPH95_10530(thpD) EPH95_17035(thpD)
SCIB : HUG20_00440(thpD) HUG20_05415(thpD)
SCIA : HUG15_00695(thpD) HUG15_07680(thpD)
PSPN : L1F29_15935(thpD) L1F29_27085
NTP : CRH09_08825(thpD) CRH09_28080(thpD)
NWL : NWFMUON74_21420(ectD)
NSPU : IFM12276_27610(ectD)
RHA : RHA1_ro04580 RHA1_ro04934
ROP : ROP_44930(ectD) ROP_50010(ectD)
ROA : Pd630_LPD01050 Pd630_LPD01448
RKO : JWS14_24980(thpD) JWS14_27240(thpD)
ROZ : CBI38_04230 CBI38_28570
RPSK : JWS13_17325(thpD) JWS13_20025(thpD)
TPUL : TPB0596_40050(thpD)
DTM : BJL86_2147 BJL86_2615
SHO : SHJGH_3093 SHJGH_8431
STRP : F750_0924 F750_1726
SCW : TU94_03765 TU94_07930
SAMB : SAM23877_1941(ectD)
SRW : TUE45_01704 TUE45_02348 TUE45_03036
SLE : sle_52670(sle_52670)
STSI : A4E84_09420 A4E84_36765
SGM : GCM10017557_63920(ectD)
SALJ : SMD11_5132(ectD) SMD11_6819(ectD)
SGD : ELQ87_00200(thpD) ELQ87_30210(thpD)
STUI : GCM10017668_14640(ectD)
SHK : J2N69_07715(thpD) J2N69_33620(thpD)
SGOB : test1122_02425(thpD)
SXT : KPP03845_100690(ectD)
STTN : BSL84_29480 BSL84_30145
NEX : NE857_06630(thpD) NE857_15330(thpD)
NCG : KGD84_11965(thpD) KGD84_26990
SNAH : OUQ99_26655(thpD) OUQ99_30355(thpD)
AGRA : AGRA3207_003665(thpD) AGRA3207_006984(thpD)
PPEL : H6H00_10595(thpD) H6H00_26500(thpD)
PMAD : BAY61_17755 BAY61_28350
ACTU : Actkin_00431 Actkin_03251
NAV : JQS30_12445(thpD) JQS30_12450(thpD)
» show all
Taxonomy
Reference
Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
Journal
Sequence
Reference
Authors
Bursy J, Kuhlmann AU, Pittelkow M, Hartmann H, Jebbar M, Pierik AJ, Bremer E
Title
Synthesis and uptake of the compatible solutes ectoine and 5-hydroxyectoine by Streptomyces coelicolor A3(2) in response to salt and heat stresses.
Journal
Sequence
Reference
Authors
Reuter K, Pittelkow M, Bursy J, Heine A, Craan T, Bremer E
Title
Synthesis of 5-hydroxyectoine from ectoine: crystal structure of the non-heme iron(II) and 2-oxoglutarate-dependent dioxygenase EctD.
Journal
Sequence
Other DBs