KEGG ENZYME: 1.14.11.64

ENZYME: 1.14.11.64

Entry

EC 1.14.11.64               Enzyme

Name

glutarate dioxygenase;
csiD (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

Sysname

glutarate, 2-oxoglutarate:oxygen oxidoreductase ((S)-2-hydroxyglutarate-forming)

Reaction(IUBMB)

glutarate + 2-oxoglutarate + O2 = (S)-2-hydroxyglutarate + succinate + CO2 [RN:R12216]

Reaction(KEGG)

R12216

Substrate

glutarate [CPD:C00489];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]

Product

(S)-2-hydroxyglutarate [CPD:C03196];
succinate [CPD:C00042];
CO2 [CPD:C00011]

Comment

Requires iron(II). The enzyme, characterized from the bacteria Escherichia coli and Pseudomonas putida, participates in L-lysine degradation in many bacteria. It provides an alternative route for L-glutarate degradation that does not proceed via CoA-activated intermediates.

History

EC 1.14.11.64 created 2019

Pathway

ec00310

Lysine degradation

ec01100

Metabolic pathways

Orthology

K15737

glutarate dioxygenase

Genes

ECO:	b2659(glaH)

ECJ:	JW5427(ygaT)

ECD:	ECDH10B_2826(ygaT)

EBW:	BWG_2402(csiD)

ECOC:

C3026_14660

ECE:

Z3956

ECS:	ECs_3520(csiD)

ECF:	ECH74115_3901

ETW:	ECSP_3604(ygaT)

ELX:	CDCO157_3281

EOI:	ECO111_3383(csiD)

EOJ:	ECO26_3728(csiD)

EOH:	ECO103_3200(csiD)

ECOO:

ECRM13514_3497(csiD)

ECOH:

ECRM13516_3363(csiD)

ESL:

O3K_06255

ESO:

O3O_19390

ESM:

O3M_06300

ECK:	EC55989_2927(ygaT)

ECG:	E2348C_2922(csiD)

EOK:	G2583_3305(csiD)

ELR:	ECO55CA74_15740

ELH:

ETEC_2856

ECW:	EcE24377A_2939

EUN:	UMNK88_3328

ECP:

ECP_2622

ENA:	ECNA114_2690

ECOS:

EC958_2923(ygaT)

ECV:	APECO1_3861(ygaT)

ECOA:

APECO78_16885

ECX:	EcHS_A2794

ECM:	EcSMS35_2779

ECY:

ECSE_2912

ECR:	ECIAI1_2755(ygaT)

ECQ:	ECED1_3112(ygaT)

EUM:	ECUMN_2983(ygaT)

ECT:	ECIAI39_2845(ygaT)

EOC:	CE10_3077(csiD)

EBR:	ECB_02515(csiD)

ECOB:

C3029_17255

EBL:	ECD_02515(csiD)

EBE:	B21_02479(csiD)

EBD:

ECBD_1060

ECI:	UTI89_C3014(ygaT)

EIH:	ECOK1_3025

ECZ:	ECS88_2923(ygaT)

ECC:	c3207(ygaT)

ELO:	EC042_2856(csiD)

ELN:	NRG857_13015

ESE:

ECSF_2456

ECL:	EcolC_1047

EKO:	EKO11_1112

EKF:	KO11_09710(csiD)

EAB:	ECABU_c29220(ygaT)

EDH:	EcDH1_1024

EDJ:	ECDH1ME8569_2575(csiD)

ELU:	UM146_03295

ELW:	ECW_m2856(csiD)

ELL:	WFL_13955(csiD)

ELC:	i14_2938(ygaT)

ELD:	i02_2938(ygaT)

ELP:	P12B_c2768

ELF:	LF82_0367(csiD)

ECOL:

LY180_13470

ECOI:

ECOPMV1_02911(csiD)

ECOJ:

P423_14570

EFE:	EFER_0413(ygaT)

EAL:	EAKF1_ch3338c

EMA:	C1192_22395

ESZ:	FEM44_03115(csiD)

ERUY:

OSH18_18385(glaH)

STY:

STY2909

STT:

t2684

SEX:	STBHUCCB_28260

SENT:

TY21A_13595

STM:

STM2789

SEO:	STM14_3365

SEV:	STMMW_27561

SEY:	SL1344_2773(csiD)

SEM:	STMDT12_C28420

SEJ:	STMUK_2777

SEB:	STM474_2924

SEF:	UMN798_3028(csiD)

SETU:

STU288_14115

SETC:

CFSAN001921_03135

SENR:

STMDT2_26941(csiD)

SEND:

DT104_27911(csiD)

SENI:

CY43_14580

SEEN:

SE451236_20040

SPT:

SPA2646

SEK:

SSPA2467

SPQ:	SPAB_03465

SEI:

SPC_2832

SEC:	SCH_2721(ygaT)

SHB:

SU5_03274

SENH:

CFSAN002069_18325

SEEH:

SEEH1578_22755

SEE:	SNSL254_A2986

SENN:

SN31241_38790

SENS:

Q786_13395

SEG:

SG2694

SEL:

SPUL_2783

SEGA:

SPUCDC_2769

SET:

SEN2633

SENA:

AU38_13360

SENO:

AU37_13370

SENV:

AU39_13370

SENQ:

AU40_15050

SENL:

IY59_13955

SENJ:

CFSAN001992_19575

SEEC:

CFSAN002050_20230

SEEB:

SEEB0189_006230

SEEP:

I137_13260

SENB:

BN855_28250

SENE:

IA1_13315

SENC:

SEET0819_20755

SES:	SARI_00184

SBG:

SBG_2414

SBZ:

A464_2810

SBV:	N643_11780

SALZ:

EOS98_05600(csiD)

SFL:

SF2686

SFX:

S2871

SFV:

SFV_2844

SFE:	SFxv_2945(csiD)

SFN:

SFy_3810

SFS:

SFyv_3891

SFT:	NCTC1_02953(csiD)

SSN:

SSON_2803

SBO:

SBO_2860

SBC:	SbBS512_E3222

SHQ:	A0259_16890

KPN:	KPN_00258(csiD)

KPU:

KP1_1104

KPM:	KPHS_09840

KPP:

A79E_4032

KPH:	KPNIH24_23865

KPZ:	KPNIH27_04775

KPV:	KPNIH29_05165

KPW:	KPNIH30_05195

KPY:	KPNIH31_02855

KPG:	KPNIH32_05200

KPC:	KPNIH10_04945

KPQ:	KPR0928_04955

KPT:	VK055_2308

KPO:	KPN2242_03710

KPJ:

N559_4163

KPI:	D364_01260

KPA:	KPNJ1_04463

KPS:	KPNJ2_04415

KPX:	PMK1_02563

KPB:	FH42_22145

KPNE:

KU54_021550

KPNU:

LI86_21390

KPNK:

BN49_1226(csiD)

KVA:

Kvar_4129

KPE:	KPK_4474(csiD)

KPK:	A593_15695

KVD:	KR75_13100

KVQ:	SP68_19770

KQU:	AVR78_09610

EAE:

EAE_12085

EAR:

CCG31546

KQV:	B8P98_22305

KAR:	LGL98_20060(csiD)

RON:	TE10_07025

RTG:	NCTC13098_05981(csiD_1)

CKO:

CKO_04006

CFD:	CFNIH1_00295

CBRA:

A6J81_22950

CWE:	CO701_04185

CYO:	CD187_05685

CPOT:

FOB25_16995(csiD)

CFQ:	C2U38_19285

CSED:

JY391_05210(csiD)

CAMA:

F384_14485

CAF:	AL524_08600

CIF:	AL515_17920

CFAR:

CI104_19485

CIR:	C2U53_29560

CIE:	AN232_10180

CPAR:

CUC49_13720

CTEL:

GBC03_10280(csiD)

CITZ:

E4Z61_22235(csiD)

CARS:

E1B03_20420(csiD)

CIX:	M4I31_05525(csiD)

CIB:	HF677_005450(csiD)

CENS:

P2W74_05305(glaH)

EBT:	EBL_c30580

PGE:	LG71_05945

ESC:	Entcl_0874

KLE:	AO703_17215

LAX:	APT61_19755

LEI:	C2U54_07550

LEH:	C3F35_09135

LEE:	DVA44_21225

LER:	GNG29_02795(csiD)

LEA:	GNG26_02395(csiD)

LEY:	DVA43_15155

YRE:	HEC60_00015(csiD)

IZH:	FEM41_10615(csiD)

PSGC:

G163CM_17800(glaH)

TOE:	QMG90_15925(glaH)

EBF:

D782_2799

EBU:	CUC76_10305

EBB:	F652_2682(csiD)

SFO:	Z042_17335

HAV:	AT03_18560

HPAR:

AL518_08030

OPO:	DSM2777_06840

VNA:	PN96_18440

VEJ:	VEJY3_18006

VFU:	vfu_B01320

PGH:	FH974_24105(csiD)

PRE:	PCA10_49700(csiD)

PFUW:

KF707C_14030 KF707C_41190

PCQ:	PcP3B5_44510

PPU:	PP_2909(csiD)

PPF:

Pput_2782

PPG:	PputGB1_2874

PPT:

PPS_3002

PPB:	PPUBIRD1_2827

PPI:

YSA_10038

PPX:

T1E_0473

PPUH:

B479_14930

PPUT:

L483_12730

PPUN:

PP4_29100(csiD)

PPUD:

DW66_3269

PMON:

X969_14385

PMOT:

X970_14030

PPJ:	RK21_01650 RK21_02891

PALD:

LU682_016095(glaH)

PIX:	RIN61_24555(glaH)

PMOS:

O165_009775

PFN:	HZ99_03380

PKR:	AYO71_16565

PSV:	PVLB_22550

PSK:	U771_16055

PKC:	PKB_4027(csiD)

PPSL:

BJP27_05680

PSET:

THL1_1563 THL1_561

PANH:

HU763_011575(csiD)

PWZ:	J7655_09260(csiD)

PCAV:

D3880_00670(csiD)

PASI:

LG197_20595(csiD)

PKM:	PZ739_15440(glaH)

PTAI:

ICN73_20950(csiD)

PKK:	QQ992_14130(glaH)

PSJY:

AA098_12625

CPS:

CPS_4661

CBER:

B5D82_16465

PIN:

Ping_2737

LPH:	LPV_0222(csiD)

CSA:

Csal_1996

HCS:	FF32_16800

HSI:	BOX17_04720

HBE:	BEI_0618(csiD)

HBP:	HPTD01_2794

HHAO:

QWG60_02875(glaH)

HASO:

B2G49_06005

HALW:

B6N23_13310(glaH)

HALK:

CUU95_14185

HVN:	EI420_11305(csiD)

MRZ:	KDW95_00995(csiD)

NJP:	NEJAP_2465(csiD)

AJP:	AMJAP_1265(csiD)

ENW:	MJO57_10535(csiD)

EMP:	EZMO1_2685(csiD)

OCE:

GU3_03510

OPE:	PU634_14530(glaH)

ZDF:	AN401_01065

IGN:	MMG00_06370(csiD)

WCN:	PE074_01960(glaH)

TSN:	W908_02520

THIN:

CRN91_07610

NLS:	PJU73_07010(glaH)

CCAH:

DWG20_12830

RPJ:	N234_30460

CNC:	CNE_BB1p02240(csiD)

CUH:	BJN34_08410

REU:	Reut_A1662

CUK:	KB879_38140(csiD)

BUZ:	AYM40_06960 AYM40_24995

PSPW:

BJG93_33550(csiD)

PPAI:

E1956_36745(csiD)

PPK:	U875_05070

PPNO:

DA70_22145

PRB:	X636_04355

CABA:

SBC2_52260(glaH)

CABK:

NK8_44620(csiD)

BAV:	BAV3238(csiD)

BHZ:	ACR54_03871

BPDZ:

BBN53_03650

AIS:	BUW96_04605

PARK:

LSG25_13825(csiD)

CTT:	CtCNB1_3674

CTES:

O987_21475

CRJ:	QMY55_18075(glaH)

HYN:	F9K07_22130(csiD)

PUB:	SAR11_1354(gab)

PEL:	SAR11G3_00795

PEG:	E5R92_06485(csiD)

APM:	HIMB5_00009960

HFE:	HFELIS_13920

HBI:	HBZC1_12310

HBL:	XJ32_10720

HAIL:

ASB7_01760(csiD)

BTM:

MC28_0159

BWE:	BcerKBAB4_0797

BWW:	bwei_4105(csiD)

BMYO:

BG05_5008(csiD)

BTY:	Btoyo_3570

BMYC:

DJ92_3470(csiD)

BNT:	GSN03_04955(csiD)

BFD:	NCTC4823_03324(csiD)

BBAD:

K7T73_01470(csiD)

BARD:

QRY57_06375(glaH)

HHD:	HBHAL_4197

HMN:	HM131_05905

HLI:

HLI_15330

HSHI:

MUO14_09510(csiD) MUO14_15215(csiD)

FEC:	QNH15_15865(glaH) QNH15_15900(glaH) QNH15_15905(glaH)

BSJ:	UP17_12210

PBUT:

DTO10_25105

PFRI:

L8956_12845(csiD)

NMK:	CHR53_04645

NCM:	QNK12_05030(glaH)

MSEM:

GMB29_11690(csiD)

SFOR:

QNH23_12310(glaH)

PNP:	IJ22_14190 IJ22_35750

ANX:	ACH33_12815

ASOC:

CB4_03263

ATHE:

K3F53_06115(csiD)

SPAE:

E2C16_04230(csiD)

PANC:

E2636_12560(csiD)

» show all

Reference

1 [PMID:30498244]

Authors

Knorr S, Sinn M, Galetskiy D, Williams RM, Wang C, Muller N, Mayans O, Schleheck D, Hartig JS

Title

Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate.

Journal

Nat Commun 9:5071 (2018)
DOI:10.1038/s41467-018-07563-6

Sequence

[eco:b2659]

Reference

2 [PMID:29844506]

Authors

Zhang M, Gao C, Guo X, Guo S, Kang Z, Xiao D, Yan J, Tao F, Zhang W, Dong W, Liu P, Yang C, Ma C, Xu P

Title

Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving L-2-hydroxyglutarate.

Journal

Nat Commun 9:2114 (2018)
DOI:10.1038/s41467-018-04513-0

Sequence

[ppu:PP_2909]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.11.64

IUBMB Enzyme Nomenclature:

1.14.11.64

ExPASy - ENZYME nomenclature database:

1.14.11.64

BRENDA, the Enzyme Database:

1.14.11.64

DBGET integrated database retrieval system