KEGG ENZYME: 1.14.11.7

ENZYME: 1.14.11.7

Entry

EC 1.14.11.7                Enzyme

Name

procollagen-proline 3-dioxygenase;
proline,2-oxoglutarate 3-dioxygenase;
prolyl 3-hydroxylase;
protocollagen proline 3-hydroxylase;
prolyl-4-hydroxyprolyl-glycyl-peptide,2-oxoglutarate:oxygen oxidoreductase, 3-hydroxylating

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

Sysname

[procollagen]-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)

Reaction(IUBMB)

[procollagen]-L-proline + 2-oxoglutarate + O2 = [procollagen]-trans-3-hydroxy-L-proline + succinate + CO2 [RN:R03218]

Reaction(KEGG)

R03218

Substrate

[procollagen]-L-proline [CPD:C01078];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]

Product

[procollagen]-trans-3-hydroxy-L-proline [CPD:C04397];
succinate [CPD:C00042];
CO2 [CPD:C00011]

Comment

Requires Fe2+ and ascorbate. The enzyme forms a complex with protein disulfide isomerase, and is located in the endoplasmic reticulum. It modifies proline residues within the procollagen peptide of certain collagen types. The modification is essential for proper collagen triple helix formation.

History

EC 1.14.11.7 created 1981, modified 1983, modified 2017

Orthology

K08134

procollagen-proline 3-dioxygenase 1

K22459

procollagen-proline 3-dioxygenase 2

K22460

procollagen-proline 3-dioxygenase 3

Genes

HSA:	10536(P3H3) 55214(P3H2) 64175(P3H1)

PTR:	100612169(P3H3) 456811(P3H1) 740124(P3H2)

PPS:	100967913(P3H3) 100988847(P3H2) 100995838(P3H1)

GGO:	101124810(P3H2) 101134181(P3H3) 101141437(P3H1)

PON:	100445803(P3H2) 100452759(P3H3) 100454619(P3H1)

NLE:	100579995(P3H2) 100580431(P3H1) 100592815(P3H3)

HMH:	116463708 116463719 116472603(P3H3) 116479962(P3H2)

MCC:	697917(P3H1) 704118(P3H2) 713865(P3H3)

MCF:	102115049(P3H1) 102125709(P3H3) 102137302(P3H2)

MTHB:

126930430 126948022 126959335

MNI:	105470865(P3H2) 105484207(P3H3) 105494858(P3H1)

CSAB:

103218477(P3H3) 103224997(P3H1) 103241897(P3H2)

CATY:

105575197(P3H2) 105583037(P3H3) 105594659(P3H1)

PANU:

101023075(P3H1) 101025099(P3H2) 101026956(P3H3)

TGE:	112619528(P3H2) 112621500(P3H1) 112634137(P3H3)

MLEU:

105540664(P3H2) 105541806(P3H3) 105555039(P3H1)

RRO:	104669007(P3H1) 104680052(P3H2) 104680134(P3H3)

RBB:	108530367(P3H1) 108530476(P3H2) 108542032(P3H3)

TFN:	117084375(P3H2) 117090611(P3H3) 117092759(P3H1)

PTEH:

111544367(P3H2) 111548713(P3H1) 111555923(P3H3)

CANG:

105514008(P3H1) 105519018(P3H3) 105525834(P3H2)

CJC:	100385724(P3H3) 100388266(P3H2) 100402370(P3H1)

SBQ:	101029883 101038436(LEPREL1) 101052278(LEPRE1)

CIMI:

108295001(P3H3) 108313377(P3H1) 108318523(P3H2)

CSYR:

103274069(P3H2) 103275194(P3H1)

MMUR:

105860445(P3H2) 105862270(P3H1) 105868996(P3H3)

LCAT:

123630385(P3H2) 123634275(P3H1) 123640102(P3H3)

PCOQ:

105805047(P3H3) 105806715(P3H2) 105812312(P3H1)

OGA:	100951275(P3H3) 100953257(P3H2) 100960942(P3H1)

MMU:	14789(P3h3) 210530(P3h2) 56401(P3h1)

MCAL:

110292274(P3h1) 110295793(P3h3) 110311568(P3h2)

MPAH:

110316244(P3h3) 110322804(P3h1) 110329669(P3h2)

RNO:	114200(P3h1) 288016(P3h2)

MCOC:

116085767(P3h2) 116095760(P3h1) 116099583(P3h3)

ANU:	117708874(P3h1) 117715408(P3h3) 117718224(P3h2)

MUN:	110542144(P3h2) 110547455(P3h1) 110548595(P3h3)

CGE:	100752370(P3h2) 100767056(P3h3) 100769529(P3h1)

MAUA:

101842039(P3h3) 101843136(P3h2) 101844959(P3h1)

PROB:

127212848(P3h3) 127225263(P3h1) 127227019(P3h2)

PLEU:

114697097(P3h2) 114704940(P3h1) 114708824(P3h3)

MORG:

121443056(P3h3) 121448761(P3h1) 121465132(P3h2)

MFOT:

126512308 126513092 126514890

AAMP:

119807780(P3h3) 119817502(P3h1) 119824997(P3h2)

NGI:	103727504(P3h3) 103739336(P3h2) 103741906(P3h1)

HGL:	101709763(P3h2) 101719240(P3h3) 101725544(P3h1)

CPOC:

100713593(P3h2) 100714440(P3h1) 100734213(P3h3)

CCAN:

109678351(P3h2) 109682771(P3h3) 109691192(P3h1)

DORD:

105986002(P3h1) 105987863(P3h2) 105991075(P3h3)

DSP:	122098574(P3h2) 122101947(P3h3) 122110913(P3h1)

PLOP:

125351879(P3h2) 125355008(P3h1)

NCAR:

124964291 124982086 124993301

MMMA:

107141881(P3h1) 107154377(P3h2) 107154941(P3h3)

OCU:	100344567 100356128 100357143

OPI:	101532483(P3H3) 101533941(P3H2) 101534730(P3H1)

TUP:	102468745(P3H1) 102489939(P3H3) 102490664(P3H2)

GVR:	103586410(LEPREL2) 103590826(LEPRE1) 103593056(LEPREL1)

CFA:	100686626(P3H3) 478674(P3H2) 606980(P3H1)

CLUD:

112642256(P3H1) 112645824(P3H2) 112675352(P3H3)

VVP:	112908251(P3H1) 112917513(P3H3) 112926308(P3H2)

VLG:	121477368(P3H2) 121479875(P3H3) 121481251(P3H1)

NPO:	129498620(P3H2) 129503453(P3H3) 129520625(P3H1)

AML:	100477435(P3H1) 100482440(P3H3) 100484169(P3H2)

UMR:	103656188(P3H3) 103670920(P3H1) 103676024(P3H2)

UAH:	113253554(P3H2) 113254805(P3H1) 113257960(P3H3)

UAR:	123781658(P3H3) 123793817(P3H1) 123801275(P3H2)

ELK:	111143043 111149280 111159772

LLV:	125097086 125102140 125106049

MPUF:

101681875(P3H2) 101682820(P3H1) 101683319(P3H3)

MNP:	132000695(P3H1) 132011938(P3H2) 132019911(P3H3)

MLK:	131809104(P3H1) 131824729(P3H2) 131838463(P3H3)

NVS:	122892607(P3H3) 122899840(P3H1) 122908804(P3H2)

ORO:	101366397(P3H1) 101370866(P3H3) 101373687(P3H2)

EJU:	114207098(P3H2) 114222611(P3H3) 114224201(P3H1)

ZCA:	113911494(P3H1) 113918448(P3H2) 113921347(P3H3)

MLX:	118006941(P3H2) 118019539(P3H1) 118025727(P3H3)

NSU:	110574953(P3H1) 110580950(P3H3) 110582618(P3H2)

LWW:	102731281(P3H2) 102741085(P3H3) 102743362(P3H1)

FCA:	101093365(P3H3) 101094278(P3H1) 101094873(P3H2)

PYU:	121021963(P3H3) 121026960(P3H1) 121034146(P3H2)

PCOO:

112849643(P3H2) 112863374(P3H1) 112867653(P3H3)

PBG:	122472380(P3H3) 122480360(P3H1) 122491612(P3H2)

PVIV:

125169795(P3H3) 125172939(P3H1) 125175131(P3H2)

LRUF:

124500963 124515996 124527028

PTG:	102950281(P3H2) 102955345(P3H3) 102958232(P3H1)

PPAD:

109254903(P3H1) 109275310(P3H2) 109276105(P3H3)

PUC:	125912702 125917978 125917988 125921087

AJU:	106965441 106968016 106970202

HHV:	120220442(P3H3) 120233112(P3H2) 120236066(P3H1)

BTA:	132345345(P3H3) 511799(P3H2) 539976(P3H1)

BOM:	102280597(P3H1) 102284601(P3H2) 102287577(P3H3)

BIU:	109556425(P3H1) 109556764(P3H2) 109558918(P3H3)

BBUB:

102394493(P3H3) 102395789(P3H1) 102400880(P3H2)

BBIS:

104992333(LEPREL2) 104996454(P3H2) 105004889(P3H1)

CHX:	102176848(P3H1) 102188119(P3H3) 102189992(P3H2)

OAS:	101105862(P3H1) 101108618(P3H2) 101108826(P3H3)

BTAX:

128044509(P3H1) 128047896(P3H3) 128049104(P3H2)

ODA:	120856313(P3H1) 120858735(P3H3) 120872670(P3H2)

CCAD:

122423967(P3H3) 122437120(P3H1) 122444797(P3H2)

MBEZ:

129536554(P3H3) 129541670(P3H1) 129544467(P3H2)

SSC:	100156539(P3H3) 100520219(P3H2) 100620503(P3H1)

CFR:	102510969(P3H3) 102516638(P3H2) 102516978(P3H1)

CBAI:

105071089(LEPREL2) 105072351(P3H2) 105072736(P3H1)

CDK:	105097544(P3H2) 105098205(P3H3) 105103354(P3H1)

VPC:	102524649(P3H2) 102530387(P3H3) 102532573(P3H1)

BACU:

103005242(P3H2) 103015069(P3H3) 103015131(P3H1)

BMUS:

118894735(P3H2) 118899981(P3H1) 118902279(P3H3)

LVE:	103076723(LEPREL1) 103081402(LEPRE1) 103090013(LEPREL2)

OOR:	101273511(P3H1) 101285801(P3H3) 101289013(P3H2)

DLE:	111172711(P3H2) 111175681(P3H1) 111176688(P3H3) 111176693

PCAD:

102977913(P3H1) 102981742(P3H3) 102993003(P3H2)

PSIU:

116753392(P3H2) 116755713(P3H1) 116760195(P3H3)

NASI:

112391958(P3H3) 112399526(P3H1) 112415541(P3H2)

ECB:	100059777(P3H2) 100060032(P3H3) 100067315(P3H1)

EPZ:	103547016(P3H3) 103557310(P3H1) 103564888(P3H2)

EAI:	106832556(P3H2) 106847326(P3H3) 106847794(P3H1)

MYB:	102239815(P3H1) 102245885(P3H2) 102248956(P3H3)

MYD:	102755248(P3H3) 102759591(P3H2) 102764443(P3H1)

MMYO:

118649723(P3H3) 118676394(P3H2) 118676688(P3H1)

MLF:	102423043(P3H2) 102427832(P3H1) 102428125(P3H3)

PKL:	118724644(P3H1) 118724946(P3H2) 118730176(P3H3)

EFUS:

103289026(P3H3) 103294839(P3H1) 103295161(P3H2)

MNA:	107527300(P3H2) 107531174(P3H1) 107543975(P3H3)

DRO:	112299410(P3H1) 112300959(P3H2) 112321730(P3H3)

SHON:

118977594(P3H1) 118981928(P3H2) 119002342(P3H3)

AJM:	119039095(P3H2) 119052336(P3H1) 119060498(P3H3)

PDIC:

114491032(P3H2) 114497760(P3H1) 114513537(P3H3)

PHAS:

123810637(P3H3) 123827488(P3H2) 123831600(P3H1)

MMF:	118617224(P3H2) 118623938(P3H3) 118626294(P3H1)

PPAM:

129069364(P3H1) 129071437(P3H3) 129071438 129079878(P3H2)

HAI:	109371222(P3H2) 109373668(P3H3) 109383352(P3H1)

RFQ:	117012781(P3H2) 117027319(P3H1) 117028942(P3H3)

PALE:

102884197(P3H1) 102890385(P3H2) 102893257(P3H3)

PGIG:

120592972(P3H2) 120607189(P3H1) 120611662(P3H3)

PVP:	105296021(P3H3) 105304022(P3H1) 105307800

RAY:	107505908(P3H2) 107508292(P3H1) 107519795(P3H3)

MJV:	108384714(P3H2) 108403547(P3H3) 108410378

TOD:	119235556(P3H1) 119247773(P3H3) 119257389(P3H2)

SARA:

101537434(P3H2) 101545227(P3H3) 101545776(P3H1)

LAV:	100658405(P3H2) 100665625(P3H1) 100675290(P3H3)

TMU:	101343909 101346635 101349558

ETF:	101660051(P3H1) 101661521(P3H3) 101664172(P3H2)

DNM:	101417141(P3H1) 101419290(P3H2) 101447593(P3H3)

MDO:	100016121(P3H3) 100032694(P3H1) 100618320(P3H2)

GAS:	123242798(P3H2) 123243213(P3H1) 123248676(P3H3)

SHR:	100914814(P3H1) 100923448(P3H3) 100933913(P3H2)

AFZ:	127539232 127555550 127558328

PCW:	110193120(P3H2) 110206219(P3H1) 110213786(P3H3)

OAA:	100081783(P3H2) 100085351(P3H1) 103168172(P3H3)

GGA:	414142(P3H1) 414143(P3H2) 418289(P3H3)

PCOC:

116235341(P3H2) 116238345(P3H1) 116239939(P3H3)

MGP:	100546471(P3H1) 100548323(P3H3) 100549834(P3H2)

CJO:	107318275(P3H2) 107318675(P3H3) 107323389(P3H1)

TPAI:

128082823(P3H2) 128085110(P3H1) 128089880(P3H3)

LMUT:

125685211(P3H3) 125697625(P3H2) 125703394(P3H1)

NMEL:

110398259(P3H2) 110398399(P3H3) 110408525(P3H1)

APLA:

101793572(P3H1) 101794735(P3H3) 101795167(P3H2)

ACYG:

106044830(P3H2) 106047855(P3H3) 106049155(P3H1)

CATA:

118247024(P3H2) 118247623(P3H3) 118258801(P3H1)

AFUL:

116492502(P3H2) 116497562(P3H1) 116502297(P3H3)

TGU:	100221140(P3H3) 100221254(P3H1) 100224069(P3H2)

LSR:	110472240(P3H1) 110473861(P3H2) 110480812(P3H3)

SCAN:

103812452(P3H3) 103815383(P3H2) 103824173

PMOA:

120498992(P3H1) 120504367(P3H2) 120506513(P3H3)

OTC:	121333074(P3H1) 121336673(P3H2) 121339254(P3H3)

PRUF:

121351585(P3H3) 121353848(P3H2) 121365790(P3H1)

GFR:	102036321(P3H1) 102040203(P3H3) 102040654(P3H2)

FAB:	101810645(P3H3) 101821011(P3H2) 101821087(P3H1)

OMA:	130256065(P3H3) 130256681(P3H2) 130261692(P3H1)

PHI:	102099220(P3H2) 102106882(P3H1) 102112679(P3H3)

PMAJ:

107208918(P3H2) 107213395(P3H3) 107213791(P3H1)

CCAE:

111933453(P3H2) 111938269(P3H3) 111938574(P3H1)

CCW:	104687224(P3H3) 104687928(P3H2) 104697539(P3H1)

CBRC:

103614062(P3H3) 103616210(P3H1) 103625159(P3H2)

ETL:	114057609(P3H2) 114058157(P3H3) 114066843(P3H1)

ZAB:	102063366(P3H3) 102064950(P3H1) 102074218(P3H2)

ACHL:

103797120(LEPRE1) 103797628(LEPREL2) 103811737(LEPREL1)

SVG:	106856449(P3H1) 106857894(P3H3) 106862517(P3H2)

MMEA:

130574783(P3H3) 130579652(P3H2) 130583070(P3H1)

HRT:	120748508(P3H3) 120757354(P3H2) 120762314(P3H1)

FPG:	101917584(P3H2) 101919025(P3H3) 101923126(P3H1)

FCH:	102048595(P3H1) 102050123(P3H2) 102055974(P3H3)

CLV:	102084407(P3H3) 102094017(P3H1) 102097675(P3H2)

EGZ:	104123376(LEPREL1) 104126599(LEPREL2) 104131732(LEPRE1)

NNI:	104011258(LEPRE1) 104015666(LEPREL1) 104022495(LEPREL2)

PCRI:

104026902(LEPRE1) 104028695(LEPREL2) 104035992(LEPREL1)

PLET:

104620548(LEPRE1) 104624766(LEPREL2) 104628721(LEPREL1)

EHS:	104504088(LEPRE1) 104513521(LEPREL2) 104514259(LEPREL1)

PCAO:

104042731(LEPRE1) 104049585(LEPREL1) 104052979(LEPREL2)

ACUN:

113476602(P3H3) 113483556(P3H2) 113487825(P3H1)

TALA:

104360794(P3H2) 104363765(P3H3) 104369444(P3H1)

PADL:

103921957(LEPREL2) 103925387(LEPREL1) 103925411(LEPRE1)

AFOR:

103901461(P3H2) 103905500(P3H3) 103906904(P3H1)

ACHC:

115343286(P3H1) 115343592(P3H3) 115347537(P3H2)

HALD:

104319100(LEPREL2) 104322359(LEPREL1)

HLE:	104831865(LEPREL2) 104835183(LEPREL1) 104837978(LEPRE1)

AGEN:

126037674 126039707 126049044

GCL:	127014949 127020268 127024724

CCRI:

104157321(LEPRE1) 104160056(LEPREL2) 104167788(LEPREL1)

CSTI:

104553598(LEPREL1) 104563840(LEPREL2)

CMAC:

104476527(LEPREL1) 104482091(LEPREL2) 104485602

MUI:	104544288(LEPRE1) 104544823(LEPREL1) 104545881(LEPREL2)

BREG:

104638771(LEPRE1) 104641458(LEPREL2) 104643058(LEPREL1)

FGA:	104081373(LEPREL1)

GSTE:

104255997 104259959 104262938(LEPREL1)

LDI:	104342865(LEPRE1) 104350897(LEPREL2) 104353045(LEPREL1)

MNB:	103773606(LEPREL1) 103780783 103782521(LEPRE1)

OHA:	104326848(LEPREL1) 104327155(LEPREL2) 104332999(LEPRE1)

NNT:	104402307(LEPREL2) 104403959(LEPREL1) 104412546(LEPRE1)

SHAB:

115601647(P3H3) 115611985(P3H2) 115617506(P3H1)

DPUB:

104299503(LEPREL2) 104300715(LEPREL1) 104305543(LEPRE1)

PGUU:

104459157(LEPREL2) 104471184(LEPREL1)

ACAR:

104521329(P3H2) 104532899(P3H3)

CPEA:

104389885(LEPREL2) 104390642(LEPRE1) 104390686(LEPREL1)

AVIT:

104268188(LEPREL2) 104270701(LEPREL1) 104276757(LEPRE1)

CVF:	104284970(LEPREL1) 104290705(LEPRE1) 104293416(LEPREL2)

RTD:	128904353(P3H3) 128911226(P3H2) 128918447(P3H1)

CUCA:

104063443(LEPREL1) 104064399(LEPREL2) 104065419(LEPRE1)

TEO:	104371718(LEPREL1) 104374330(LEPREL2) 104380509(LEPRE1)

BRHI:

104493337(LEPREL1) 104498149(LEPREL2) 104500747(LEPRE1)

AAM:	106497271(P3H3) 106498214(P3H2) 106498600(P3H1)

AROW:

112966878(P3H1) 112968533(P3H2) 112973011(P3H3)

NPD:	112952573(P3H2) 112957490(P3H1) 112960149(P3H3)

TGT:	104565680(LEPREL2) 104575329(LEPREL1) 104580913(LEPRE1)

DNE:	112979395(P3H2) 112988486(P3H1) 112991070(P3H3)

SCAM:

104148800(LEPREL1) 104150749(LEPREL2) 104153657(LEPRE1)

ASN:	102368146 102380538 102384024 102385273(P3H1)

AMJ:	102562134(P3H3) 102572352(P3H2) 106737225(P3H1)

CPOO:

109308549(P3H2) 109314287(P3H1) 109319392(P3H3)

GGN:	109288104(P3H2) 109293875(P3H1) 109304603(P3H3)

PSS:	102444832(P3H2) 102450598(P3H1) 102461480(P3H3)

CMY:	102929854(P3H3) 102932162(P3H1) 102939997(P3H2)

CCAY:

125622645(P3H3) 125624325(P3H1) 125642646(P3H2)

DCC:	119845112(P3H1) 119845973(P3H3) 119861544(P3H2)

CPIC:

101931004(P3H3) 101931818(P3H2) 101935857(P3H1)

TST:	117867966(P3H1) 117882815(P3H2) 117885801(P3H3)

CABI:

116817602(P3H1) 116823027(P3H2) 116837548(P3H3)

MRV:	120372389(P3H2) 120387981(P3H1) 120401768(P3H3)

ACS:	100562772(p3h2) 100567613(p3h3)

ASAO:

132764714(P3H1) 132767535(P3H3) 132770370(P3H2)

PVT:	110084656(P3H3) 110085947(P3H2) 110086810(P3H1)

SUND:

121923805(P3H3) 121927252(P3H2) 121937202(P3H1)

PBI:	103048096(P3H2) 103049535(P3H3) 103066967(P3H1)

PMUR:

107285772 107290023(P3H1) 107299512

CTIG:

120306096(P3H3) 120319197(P3H1) 120319828(P3H2)

TSR:

106545546

PGUT:

117661815(P3H3) 117669822(P3H2)

APRI:

131187117(P3H1) 131191768(P3H3) 131201205(P3H2)

PTEX:

113444487(P3H3) 113451599(P3H1)

NSS:	113424512(P3H3) 113427581(P3H1)

VKO:	123031046(P3H1) 123033251(P3H3) 123036774(P3H2)

PMUA:

114587602(P3H3) 114598127(P3H2) 114602593(P3H1)

PRAF:

128405255(P3H3) 128414905(P3H2) 128419653(P3H1)

ZVI:	118075322(P3H3) 118087616(P3H1) 118093536(P3H2)

HCG:	128338715(P3H1) 128342814(P3H3) 128351902(P3H2)

GJA:	107116689(P3H1) 107116803(P3H3) 107123825(P3H2)

STOW:

125436260(P3H3) 125438562(P3H2) 125446058(P3H1)

EMC:	129332204(P3H2) 129344677(P3H1) 129345649(P3H3)

XLA:	108697338(p3h3.S) 108716969(p3h2.L) 108718050 414447(p3h1.L)

XTR:	100036679(p3h1) 100496461(p3h2) 101734514 101734646 116406429(p3h3)

NPR:	108783932(P3H1) 108795998(P3H3) 108804588(P3H2)

RTEM:

120915618(P3H1) 120936859(P3H2) 120946604(P3H3)

BBUF:

120997981(P3H2) 120998118(P3H1) 121004655(P3H3)

BGAR:

122926236(P3H1) 122934556(P3H2) 122942224(P3H3)

MUO:	115456652(P3H1) 115458019(P3H3) 115478957(P3H2)

GSH:	117349168(P3H1) 117350202(P3H3) 117366300(P3H2)

DRE:	553311(p3h3) 553321(p3h1) 566697(p3h2)

SRX:	107715694 107722092 107724912 107741542(p3h2) 107751183 107756620

SANH:

107654364(p3h1) 107654416 107655408(p3h2) 107664742 107700158

SGH:	107549451(p3h3) 107560692 107564922 107565728(p3h1) 107582441

CCAR:

109048696 109051947 109081049 109092890 109103994

CAUA:

113039910 113055510 113064960 113110859 113116390

CGIB:

127943251 127968386 127974344 127988386 128022084

PTET:

122328056(p3h2) 122354651(p3h1) 122360143(p3h3)

LROH:

127173193(p3h1) 127177921(p3h3)

OMC:	131522304(p3h3) 131530023(p3h2) 131549908(p3h1)

PPRM:

120477226(p3h2) 120480458(p3h1) 120484283(p3h3)

RKG:	130103670(p3h3)

MAMB:

125244021(p3h3) 125252770(p3h2) 125256150(p3h1)

CIDE:

127497553 127521119 127522837

MASI:

127426077 127438258 127439179 127453420 127453951

TROS:

130548367(p3h2) 130558448(p3h3) 130571241(p3h1)

TDW:	130410282(p3h1) 130430716(p3h2) 130433480(p3h3)

MANU:

129427410(p3h1) 129447880(p3h3) 129453530(p3h2)

IPU:	108270766 108274273 108281059

IFU:	128608075(p3h3) 128613508(p3h2) 128624984(p3h1)

PHYP:

113537803(p3h1) 113542320(p3h3) 113547067(p3h2)

SMEO:

124385187(p3h3) 124391591(p3h2) 124402570(p3h1)

TFD:	113641863(p3h3) 113646193(p3h2) 113657265(p3h1)

TVC:	132838266(p3h1) 132846103(p3h3) 132850994(p3h2)

AMEX:

103024133(p3h1) 103026715(p3h3) 103045377(p3h2)

CMAO:

118799918(p3h1) 118818729(p3h2) 118824794(p3h3)

EEE:	113570617(p3h3) 113582372(p3h2) 113586117(p3h1)

CHAR:

105895157(p3h3) 105895868(p3h1) 105910695(p3h2)

TRU:	101075372(p3h3) 101075489(p3h1) 101076075(p3h2)

TFS:	130523752(p3h1) 130528194(p3h2) 130532927(p3h3)

TNG:	GSTEN00014179G001 GSTEN00015313G001 GSTEN00028918G001 GSTEN00028919G001

LCO:	104920250(p3h2) 104922230(p3h3) 104939521(p3h1)

NCC:	104950703 104957626(p3h1) 104965937

TBEN:

117475688(p3h1) 117494786(p3h3) 117495711(p3h2)

CGOB:

115007391(p3h2) 115008260(p3h1)

PGEO:

117445153(p3h2) 117446711(p3h1) 117460707(p3h3)

GACU:

117532965(p3h1) 117549559(p3h3) 117555098(p3h2)

EMAC:

134861241(p3h3) 134869684(p3h2) 134883534(p3h1)

ELY:	117254207(p3h2) 117260457(p3h1) 117265415(p3h3)

EFO:	125885462(p3h1) 125893104(p3h3) 125895266(p3h2)

PLEP:

121945239(p3h3) 121951726(p3h1) 121966392(p3h2)

SLUC:

116036624 116049730(p3h3) 116055318(p3h2)

ECRA:

117942804(p3h1) 117946205(p3h3) 117950637(p3h2)

ESP:	116691224(p3h3) 116695386(p3h2)

PFLV:

114554208(p3h1) 114557467(p3h3) 114562108(p3h2)

GAT:	120810814(p3h3) 120823947(p3h2) 120835102(p3h1)

PPUG:

119197220(p3h3) 119216991(p3h2) 119229818(p3h1)

AFB:	129094470(p3h2) 129105848(p3h1) 129109527(p3h3)

CLUM:

117730104(p3h2) 117731391(p3h1) 117745453(p3h3)

PSWI:

130193791(p3h2) 130213447(p3h3)

MSAM:

119886929(p3h1) 119897412(p3h3) 119900664(p3h2)

SCHU:

122877277(p3h2) 122882018(p3h3) 122883130(p3h1)

CUD:	121507571(p3h1) 121512077(p3h2) 121513008(p3h3)

ALAT:

119006313(p3h3) 119021918(p3h1) 119028168(p3h2)

MZE:	101465294(p3h1) 101479402(p3h2) 101486114(p3h3)

ONL:	100699187(p3h2) 100708165(p3h1) 100708642(p3h3)

OAU:	116323755(p3h3) 116324692(p3h2) 116332067(p3h1)

OLA:	101170663(p3h2) 101171860(p3h3) 101172073(p3h1)

OML:	112143647(p3h3) 112144912(p3h1) 112150784(p3h2)

CSAI:

133435175(p3h3) 133449179(p3h1) 133458453(p3h2)

XMA:	102223713(p3h2) 102234680(p3h3) 102238287(p3h1)

XCO:	114136016(p3h1) 114142259(p3h3) 114150787(p3h2)

XHE:	116711012(p3h1) 116717846(p3h3) 116725527(p3h2)

PRET:

103464183(p3h2) 103465445(p3h1) 103477971(p3h3)

PFOR:

103136767(p3h3) 103138543(p3h2) 103150287(p3h1)

PLAI:

106951135(p3h3) 106955524(p3h2) 106956034(p3h1)

PMEI:

106920146(p3h1) 106926283(p3h2) 106927927(p3h3)

GAF:	122830987(p3h3) 122833669(p3h1) 122838659(p3h2)

PPRL:

129358160(p3h1) 129371158(p3h3) 129372421(p3h2)

CVG:	107082187(p3h3) 107101026(p3h2) 107104181(p3h1)

CTUL:

119774605(p3h2) 119777180(p3h1) 119783137(p3h3)

GMU:	124857160(p3h1) 124865506(p3h3) 124874119(p3h2)

NFU:	107373178 107379477(p3h3) 107392670(p3h2)

KMR:	108230631(p3h2) 108235396(p3h3) 108250443(p3h1)

ALIM:

106521056(p3h3) 106527403(p3h1) 106537303(p3h2)

NWH:	119407796(p3h2) 119409373(p3h3) 119411644(p3h1)

AOCE:

111571080(p3h3) 111574099(p3h1) 111578231 111585771(p3h2)

MCEP:

125007430(p3h1) 125009368(p3h2) 125015765(p3h3)

CSEM:

103386606(p3h1) 103387968(p3h3) 103392998(p3h2)

POV:	109625858(p3h2) 109629287(p3h1) 109633247(p3h3)

SSEN:

122760895(p3h1) 122774119(p3h3) 122780942(p3h2)

HHIP:

117759980(p3h2) 117761748(p3h1) 117776777(p3h3)

HSP:	118105215(p3h1) 118113174(p3h3) 118121489(p3h2)

SMAU:

118309308(p3h1) 118314808(p3h3) 118317710(p3h2)

LCF:	108877527 108880725 108881307

SDU:	111217020(p3h2) 111221750(p3h1) 111230047(p3h3)

SLAL:

111650235(p3h2) 111668691(p3h1) 111669862(p3h3)

XGL:	120783468(p3h1) 120784068(p3h3) 120790884(p3h2)

HCQ:	109515135(p3h1) 109515281(p3h3) 109522012(p3h2)

SSCV:

125969480 125975665 125976992

SBIA:

133500694(p3h3) 133504147(p3h2) 133507035(p3h1)

PEE:	133401406(p3h3) 133406398(p3h2) 133408613(p3h1)

PTAO:

133479109(p3h3) 133480551(p3h2) 133483174(p3h1)

BPEC:

110160074(p3h2) 110163193(p3h3) 110171175(p3h1)

MALB:

109953105 109953107 109958232(p3h2) 109966171(p3h3)

BSPL:

114843080(p3h3) 114854438(p3h2) 114856242(p3h1)

SJO:	128355600(p3h1) 128361887(p3h2) 128365823(p3h3)

SASA:

106565637(p3h1) 106573995 106583105 106583419 106605089 106613518

STRU:

115150640 115151549 115157986 115176450 115177280 115207766

OTW:	112218132(p3h1) 112223120 112246567 112250630(p3h2) 112253254 112254543

OMY:	110489468 110494379(p3h1) 110518017(p3h3) 110524034 110528058 110534688

OGO:	123997218 123997415 123997954 124003057(p3h1) 124005572(p3h3) 124020035

ONE:	115108076 115139366 115141338 115141339 115143227(p3h1)

OKI:	109889038 109891088 109896147(p3h1) 109902181(p3h3) 109902278 109910242

OKE:	118364243 118367318 118370845 118386998 118388516(p3h1) 118401550

SALP:

111952665 111965230(p3h3) 111965231 111970041 111975684 111975807

SNH:	120031264 120047544 120053647 120054624 120060877(p3h1) 120065128 120065944

CCLU:

121533753(p3h2) 121564971(p3h3) 121575310(p3h1) 121576538 121577669

ELS:	105007738(p3h2) 105028240(p3h3) 105030006(p3h1)

SFM:	108922091(p3h3) 108937368(p3h2) 108938176(p3h1)

PKI:	111835368(p3h3) 111836557 111838779

AANG:

118209301(p3h3) 118210623(p3h1) 118226537(p3h2)

LOC:	102685978(p3h1) 102689642(p3h3) 102697448(p3h2)

PSPA:

121323343 121325618(p3h3) 121325619 121327002 121328843 121329236

ARUT:

117417318 117422935 117425925(p3h3) 117432040(p3h1)

PSEX:

120530950(p3h1) 120535749(p3h3) 120537172(p3h2)

LCM:	102348936(P3H3) 102353193(P3H2) 102356877(P3H1)

CMK:	103181352(p3h1) 103191590

RTP:	109915299(p3h1) 109919539

CPLA:

122540219(p3h1) 122556097(p3h2)

HOC:	132821821(p3h2) 132825300 132833504(p3h1)

LERI:

129703436(p3h2) 129710491 129711432(p3h1)

PMRN:

116946894(P3H1)

LRJ:	133351137(P3H1)

BFO:	118424124 118430516

BBEL:

109478102 109484134

CIN:	445606(leprecan)

SCLV:

120328236

APLC:

110983136

SKO:

100313646

AME:

725819

ACER:

108003674

ALAB:

122720818

ADR:

102674496

AFLR:

100864260

BIM:

100740426

BBIF:

117211594

BVK:

117241281

BVAN:

117158597

BTER:

100650141

BAFF:

126919223

BPYO:

122566466

BPAS:

132910915

FVI:

122538823

CCAL:

108630344

OBB:

114873602

OLG:

117600929

MGEN:

117229130

NMEA:

116429887

CGIG:

122399782

SOC:

105202130

MPHA:

105840059

AEC:

105148061

ACEP:

105624115

PBAR:

105427498

VEM:

105568238

HST:

105190225

DQU:

106747649

CFO:

105259052

FEX:

115244475

LHU:

105679345

PGC:

109859021

OBO:

105282343

PCF:

106788117

PFUC:

122518292

VVE:

124950922

NVI:

100123941

CSOL:

105366801

TPRE:

106658373

MDL:

103575387

CGLO:

123269381

FAS:

105263645

DAM:

107045680

AGIF:

122851580

VCAN:

122414355

CCIN:

107267355

TCA:

657387

CSET:

123312060

AGB:

108916913

NVL:

108566762

OTU:

111414178

FOC:

113209395

TPAL:

117639497

ZNE:

110827209

CSEC:

111870092

PVM:

113810720

PJA:

122264075

PMOO:

119587995

HAME:

121877169

PCLA:

123744942 123771862

CQD:

128689794

PTRU:

123508532

ESN:

126983829

HAZT:

108668164

LSM:

121127797

PPOI:

119092956 119112432

DSV:	119434090 119435045 119435461

RSAN:

119381732 119404933

RMP:	119165004 119181775

CSCU:

111620029 111620050

PTEP:

107455616

ABRU:

129964166

UDV:	129216476 129216477

SDM:

118194559

LPOL:

106457621

HRO:	HELRODRAFT_181486

LGI:	LOTGIDRAFT_91939

PVUL:

126825556

PCAN:

112559825

BGT:

106069840

GAE:

121381414

HRF:

124115558

HRJ:

124262637

CRG:

105325684

MYI:	110459992 110459993

PMAX:

117335915 117336334

MMER:

123536171

RPHI:

132735786

OSN:

115211627

LAK:

106160773

NVE:

5517048

EPA:

110243698

ATEN:

116308765

ADF:

107344196

AMIL:

114949534

PDAM:

113667901

DGT:

114523086

XEN:

124453691

HMG:

100203735

HSY:

130628607

AQU:

100638799

GMX:

100788718

GSJ:

114421545

PVU:	PHAVU_002G181600g

VRA:

106768895

VAR:

108347895

VUN:

114178277

VUM:

124844233

LJA:	Lj4g3v2406420.1(Lj4g3v2406420.1)

LANG:

109359831

PCIN:

129311333

CSV:

101218213

CMO:

103496668

CMAX:

111487019

» show all

Reference

1 [PMID:191255]

Authors

Risteli J, Tryggvason K, Kivirikko KI.

Title

Prolyl 3-hydroxylase: partial characterization of the enzyme from rat kidney cortex.

Journal

Eur J Biochem 73:485-92 (1977)
DOI:10.1111/j.1432-1033.1977.tb11341.x

Reference

2 [PMID:204218]

Authors

Risteli J, Tryggvason K, Kivirikko KI.

Title

A rapid assay for prolyl 3-hydroxylase activity.

Journal

Anal Biochem 84:423-31 (1978)
DOI:10.1016/0003-2697(78)90060-X

Reference

3 [PMID:15044469]

Authors

Vranka JA, Sakai LY, Bachinger HP

Title

Prolyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymes.

Journal

J Biol Chem 279:23615-21 (2004)
DOI:10.1074/jbc.M312807200

Sequence

[gga:414142]

Reference

4 [PMID:18487197]

Authors

Tiainen P, Pasanen A, Sormunen R, Myllyharju J

Title

Characterization of recombinant human prolyl 3-hydroxylase isoenzyme 2, an enzyme modifying the basement membrane collagen IV.

Journal

J Biol Chem 283:19432-9 (2008)
DOI:10.1074/jbc.M802973200

Sequence

[hsa:55214]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.11.7

IUBMB Enzyme Nomenclature:

1.14.11.7

ExPASy - ENZYME nomenclature database:

1.14.11.7

BRENDA, the Enzyme Database:

1.14.11.7

CAS:	63551-75-7

DBGET integrated database retrieval system