KEGG   ENZYME: 1.14.11.71
Entry
EC 1.14.11.71               Enzyme                                 
Name
methylphosphonate hydroxylase;
phnY* (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
methylphosphonate,2-oxoglutarate:oxygen oxidoreductase (1-hydroxylating)
Reaction(IUBMB)
methylphosphonate + 2-oxoglutarate + O2 = hydroxymethylphosphonate + succinate + CO2 [RN:R12452]
Reaction(KEGG)
R12452
Substrate
methylphosphonate [CPD:C20396];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
hydroxymethylphosphonate [CPD:C06455];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires iron(II). The enzyme, characterized from the marine bacterium Gimesia maris, participates in a methylphosphonate degradation pathway.
History
EC 1.14.11.71 created 2019
Pathway
ec00440  Phosphonate and phosphinate metabolism
Orthology
K23996  methylphosphonate hydroxylase
Genes
GMR: GmarT_03190
Reference
1  [PMID:30810303]
  Authors
Gama SR, Vogt M, Kalina T, Hupp K, Hammerschmidt F, Pallitsch K, Zechel DL
  Title
An Oxidative Pathway for Microbial Utilization of Methylphosphonic Acid as a Phosphate Source.
  Journal
ACS Chem Biol 14:735-741 (2019)
DOI:10.1021/acschembio.9b00024
  Sequence
[gmr:GmarT_03190]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.71
IUBMB Enzyme Nomenclature: 1.14.11.71
ExPASy - ENZYME nomenclature database: 1.14.11.71
BRENDA, the Enzyme Database: 1.14.11.71

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Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (1)   
   InterPro (1)   
All databases (15)   

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