KEGG ENZYME: 1.14.11.72

ENZYME: 1.14.11.72

Entry

EC 1.14.11.72               Enzyme

Name

[2-(trimethylamino)ethyl]phosphonate dioxygenase;
tmpA (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

Sysname

[2-(trimethylamino)ethyl]phosphonate,2-oxoglutarate:oxygen oxidoreductase (1R-hydroxylating)

Reaction(IUBMB)

[2-(trimethylamino)ethyl]phosphonate + 2-oxoglutarate + O2 = [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + succinate + CO2 [RN:R12615]

Reaction(KEGG)

R12615

Substrate

[2-(trimethylamino)ethyl]phosphonate [CPD:C22281];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]

Product

[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate [CPD:C22271];
succinate [CPD:C00042];
CO2 [CPD:C00011]

Comment

Requires Fe2+ and ascorbate. The enzyme, found in bacteria, participates in a degradation pathway for [2-(trimethylamino)ethyl]phosphonate.

History

EC 1.14.11.72 created 2020

Orthology

K24291

[2-(trimethylamino)ethyl]phosphonate dioxygenase

Genes

MARJ:

MARI_16720

MOQ:	HWV03_17260

PAQM:

E0F26_05775 E0F26_06635

SHAI:

LMH63_14695

CCAG:

SR908_07940

HAF:	C8233_04175

HASH:

HXW73_04270 HXW73_04280

HPIS:

P1P91_13960 P1P91_14455 P1P91_14530

HNP:	SR894_19700 SR894_19760

CAMH:

LCW13_07215

COBB:

H2O77_07230

MARS:

A8C75_09130

MRZ:	KDW95_08530

TSN:	W908_07695

THIN:

CRN91_02445

PMEG:

FNZ07_29585

PPAI:

E1956_08225

MLO:

mll1440

MLN:	A9174_18900

MCI:	Mesci_3237

MCIC:

A4R28_10585

MOP:	Mesop_3629

MAM:	Mesau_03502

MAMO:

A6B35_22570

MESW:

A9K65_017530

MESP:

C1M53_13015

MHUA:

MCHK_3077

MJR:	EB229_19185

MERD:

EB233_16530

MOH:	IHQ72_17265

MMEI:

LRP31_11945

HOE:	IMCC20628_01348

PHYL:

HB779_23160

RLS:	HB780_09245

LNE:	FZC33_24920

NOH:	G5V57_30915

LABR:

CHH27_03690

LABP:

FJ695_19965

SIL:

SPO3380

SIT:	TM1040_0333

RUA:	D1823_16315

RUT:	FIU92_15150

RCON:

K3740_16490

PGA:	PGA1_c27220

PGL:	PGA2_c25240

PGD:

Gal_00705

PHP:	PhaeoP97_02668

PPIC:

PhaeoP14_02470

PHQ:	D1820_08325

OCT:	FTO60_03580

LMD:	METH_08250

LEJ:	ETW24_09560

LAQU:

R2C4_08480

LEV:	ETW23_09420

LCAE:

K3721_08720

SULZ:

C1J03_21470

SULI:

C1J05_15870

ROM:	EI983_17985

RPEL:

N7U68_11415

LALG:

LentiSH36_00731

TSCO:

R1T40_04525 R1T40_13870

SEDI:

EBB79_01655

PPSO:

QPJ95_14615

PSEB:

EOK75_16310

PAED:

G5B38_12540

CACT:

HZ995_05375

ACRO:

K3J57_14495

AMYL:

QBD29_06795

RHOC:

QTA57_03285 QTA57_08995

LVR:	T8T21_12360

THAR:

T8K17_21070 T8K17_21105

PAQI:

KW060_01785

SNEA:

NBZ79_11455 NBZ79_16040

IAM:	HC251_12395

NSPH:

BDGGKGIB_02714

» show all

Reference

1 [PMID:30789718]

Authors

Rajakovich LJ, Pandelia ME, Mitchell AJ, Chang WC, Zhang B, Boal AK, Krebs C, Bollinger JM Jr

Title

A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases.

Journal

Biochemistry 58:1627-1647 (2019)
DOI:10.1021/acs.biochem.9b00044

Sequence

[ag:WP_027237574]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.11.72

IUBMB Enzyme Nomenclature:

1.14.11.72

ExPASy - ENZYME nomenclature database:

1.14.11.72

BRENDA, the Enzyme Database:

1.14.11.72

All links

Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (1796)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (85)   
   KEGG MGENES (1710)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (6)   
   InterPro (6)   
All databases (1811)   

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