KEGG   ENZYME: 1.14.11.73
Entry
EC 1.14.11.73               Enzyme                                 
Name
[protein]-arginine 3-hydroxylase;
JMJD5 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
[protein]-L-arginine,2-oxoglutarate:oxygen oxidoreductase (3R-hydroxylating)
Reaction(IUBMB)
[protein]-L-arginine + 2-oxoglutarate + O2 = [protein]-(3R)-3-hydroxy-L-arginine + succinate + CO2 [RN:R12645]
Reaction(KEGG)
R12645
Substrate
protein-L-arginine [CPD:C00613];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
[protein]-(3R)-3-hydroxy-L-arginine [CPD:C22296];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
The enzyme, characterized from humans, catalyses the stereoselective formation of the (2S,3R)-hydroxy-L-arginine stereoisomer. So far the enzyme has been shown to act on two substrates - the 40S ribosomal protein S6 (RPS6), which is hydroxylated at R137, and, at a lower activity, RCCD1, a protein involved in chromatin stability, which is hydroxylated at R141. Even though the same stereoisomer is produced by the bacterial EC 1.14.11.47, [50S ribosomal protein L16]-arginine 3-hydroxylase, the two enzymes do not exhibit any cross-reactivity on their respective ribosomal protein substrates.
History
EC 1.14.11.73 created 2020
Orthology
K10277  [protein]-arginine 3-hydroxylase / protease
Genes
HSA79831(KDM8)
PTR454003(KDM8)
PPS100968297(KDM8)
GGO101154296(KDM8)
PON100449217(KDM8)
NLE100586240(KDM8)
HMH116471163(KDM8)
MCC703323(KDM8)
MCF102130596(KDM8)
MTHB126944455
MNI105463217(KDM8)
CSAB103230060(KDM8)
CATY105598445(KDM8)
PANU101021128(KDM8)
TGE112614175(KDM8)
MLEU105541363(KDM8)
RRO104665634(KDM8)
RBB108538874(KDM8)
TFN117087556(KDM8)
PTEH111526895(KDM8)
CANG105505600(KDM8)
CJC100411932(KDM8)
SBQ101047692(KDM8)
CIMI108308555(KDM8)
CSYR103269366(KDM8)
MMUR105879694(KDM8)
LCAT123632503(KDM8)
PCOQ105810948(KDM8)
OGA100956093(KDM8)
MMU77035(Kdm8)
MCAL110298679(Kdm8)
MPAH110332709(Kdm8)
RNO308976(Kdm8)
MCOC116102930(Kdm8)
ANU117713531(Kdm8)
MUN110563301(Kdm8)
CGE100762777(Kdm8)
MAUA101826930(Kdm8)
PROB127228308(Kdm8)
PLEU114692221(Kdm8)
MORG121457705(Kdm8)
MFOT126502303
AAMP119804081(Kdm8)
NGI103741037(Kdm8)
HGL101702352(Kdm8)
CPOC100723684(Kdm8)
CCAN109698038(Kdm8)
DORD105982151(Kdm8)
DSP122096236(Kdm8)
PLOP125340961(Kdm8)
NCAR124961381 124969902
MMMA107146877(Kdm8)
OCU100358867
OPI101530374(KDM8)
TUP102471383(KDM8)
GVR103585608(KDM8)
CFA608058(KDM8)
CLUD112640008(KDM8)
VVP112929177(KDM8)
VLG121487551(KDM8)
NPO129519357(KDM8)
AML100475840(KDM8)
UMR103657901(KDM8)
UAH113267605(KDM8)
UAR123778068(KDM8)
ELK111162296
LLV125090749
MPUF101672696(KDM8)
MNP132026796(KDM8)
MLK131819622(KDM8)
NVS122895301(KDM8)
ORO101372656(KDM8)
EJU114214500(KDM8)
ZCA113932252(KDM8)
MLX117999677(KDM8)
NSU110589888(KDM8)
LWW102742462(KDM8)
FCA101096528(KDM8)
PYU121022498(KDM8)
PCOO112856576(KDM8)
PBG122471528(KDM8)
LRUF124518012
PTG102950473(KDM8)
PPAD109256513(KDM8)
PUC125927987
AJU106966184
HHV120249047(KDM8)
BTA507905(KDM8)
BOM102264590(KDM8)
BIU109578552(KDM8)
BBUB102396937(KDM8)
BBIS104986595(KDM8)
CHX102186078(KDM8)
OAS101108800(KDM8)
BTAX128069881(KDM8)
ODA120876363(KDM8)
CCAD122433027(KDM8)
MBEZ129545471(KDM8)
SSC100519765(KDM8)
CFR102504419(KDM8)
CBAI105073659(KDM8)
CDK105098259(KDM8)
VPC102529370(KDM8)
BACU103016454(KDM8)
LVE103086446(KDM8)
OOR101280561(KDM8)
DLE111182215(KDM8)
PCAD102980433(KDM8)
PSIU116739756(KDM8)
NASI112399438(KDM8)
ECB100064574(KDM8)
EPZ103556348(KDM8)
EAI106829079(KDM8)
MYB102259370(KDM8)
MYD102752152(KDM8)
MMYO118656457(KDM8)
MLF102438886(KDM8)
MNA107544798(KDM8)
PKL118731620(KDM8)
EFUS103296221(KDM8)
HAI109386576(KDM8)
DRO112304683(KDM8)
SHON119004149(KDM8)
AJM119039337(KDM8)
PDIC114507676(KDM8)
PHAS123825484(KDM8)
MMF118642758(KDM8)
RFQ117019610(KDM8)
PPAM129076723(KDM8)
PALE102893335(KDM8)
PGIG120584520(KDM8)
PVP105309223(KDM8)
RAY107507131(KDM8)
MJV108394804(KDM8)
TOD119241808(KDM8)
SARA101557089(KDM8)
LAV100654538(KDM8)
TMU101350750
ETF101648477(KDM8)
DNM101424092(KDM8)
MDO100016278(KDM8)
GAS123230874(KDM8)
SHR100921054(KDM8)
AFZ127555698
PCW110221643(KDM8)
OAA100079268(KDM8)
GGA416583(KDM8)
PCOC116237645(KDM8)
MGP100541114(KDM8)
CJO107320716(KDM8)
TPAI128078972(KDM8)
LMUT125700791(KDM8)
NMEL110405598(KDM8)
APLA101796369(KDM8)
ACYG106046025(KDM8)
CATA118256368(KDM8)
AFUL116495165(KDM8)
TGU100221235(KDM8)
LSR110477748(KDM8)
SCAN103817553(KDM8)
PMOA120513206(KDM8)
OTC121334373(KDM8)
PRUF121365871(KDM8)
GFR102044247(KDM8)
FAB101809416(KDM8)
OMA130259264(KDM8)
PHI102107110(KDM8)
PMAJ107211302(KDM8)
CCAE111936304(KDM8)
CCW104685073(KDM8)
CBRC103615642(KDM8)
ETL114061460(KDM8)
ZAB102060949(KDM8)
ACHL103807550(KDM8)
SVG106859264(KDM8)
MMEA130576504(KDM8)
HRT120759823(KDM8)
FPG101913407(KDM8)
FCH102060265(KDM8)
CLV102088060(KDM8)
EGZ104131350(KDM8)
NNI104015286(KDM8)
PCRI104024904(KDM8)
PLET104614775(KDM8)
EHS104508529(KDM8)
ACUN113485933(KDM8)
TALA104367349(KDM8)
PADL103913936(KDM8)
AFOR103905068(KDM8)
ACHC115335910(KDM8)
HALD104320005(KDM8)
HLE104833752(KDM8)
AGEN126033900
GCL127022523
CCRI104157860(KDM8)
MUI104539355(KDM8)
BREG104634980(KDM8)
FGA104082279(KDM8)
MNB103780714(KDM8)
SHAB115606228(KDM8)
DPUB104300304(KDM8)
ACAR104518626(KDM8)
CVF104295501(KDM8)
RTD128913788(KDM8)
CUCA104065053(KDM8)
TEO104378481(KDM8)
BRHI104488181(KDM8)
AAM106486126(KDM8)
AROW112975456(KDM8)
NPD112959773(KDM8)
TGT104574763(KDM8)
SCAM104139021(KDM8)
ASN102386519(KDM8)
AMJ102575621(KDM8)
GGN109294295(KDM8)
PSS102458369(KDM8)
CMY102947016(KDM8)
CCAY125643575(KDM8)
DCC119862749(KDM8)
CPIC101944361(KDM8)
TST117883844(KDM8)
CABI116830031(KDM8)
MRV120373167(KDM8)
ACS100560548(kdm8)
ASAO132781895(KDM8)
PVT110085034(KDM8)
SUND121914579 121918188
PBI103063143(KDM8)
PMUR107302606(KDM8)
CTIG120310822(KDM8)
TSR106546607(KDM8)
PGUT117667339(KDM8)
APRI131185424(KDM8)
NSS113422573(KDM8)
VKO123034818(KDM8)
PMUA114584286(KDM8)
PRAF128401587(KDM8)
ZVI118092997(KDM8)
HCG128336596(KDM8)
GJA107106235(KDM8)
STOW125430895(KDM8)
EMC129338645(KDM8)
XLA108701551(kdm8.L)
XTR100158649(kdm8)
NPR108786201(KDM8)
RTEM120943404(KDM8)
BBUF121008601(KDM8)
BGAR122945024(KDM8)
MUO115465344(KDM8)
GSH117356723(KDM8)
DRE436936(kdm8)
SRX107727121 107745601
SANH107703337(kdm8)
SGH107564696 107568929(kdm8)
CCAR109045837(kdm8) 109094006
CAUA113049803(kdm8)
CGIB127952281
PTET122342117(kdm8)
LROH127155471(kdm8)
OMC131536805(kdm8)
PPRM120489949(kdm8)
RKG130071038(kdm8)
MAMB125270102(kdm8)
CIDE127509189
MASI127450080
TROS130560971(kdm8)
TDW130426809(kdm8)
MANU129431880(kdm8)
IPU100528124(kdm8)
IFU128600629(kdm8)
PHYP113535950(kdm8)
SMEO124376069(kdm8)
TFD113649520(kdm8)
TVC132864024(kdm8)
AMEX103044249(kdm8)
CMAO118805756(kdm8)
EEE113570735(kdm8)
CHAR122132172(kdm8)
TRU101067012(kdm8)
TFS130514987(kdm8)
TNGGSTEN00034429G001
LCO104918712(kdm8)
NCC104966029(kdm8)
TBEN117492075(kdm8)
CGOB115006077 115012357
PGEO117451778(kdm8)
GACU117548324(kdm8)
ELY117268032(kdm8)
EFO125879450(kdm8)
PLEP121956861(kdm8)
SLUC116059279(kdm8)
ECRA117958566(kdm8)
ESP116703142(kdm8)
PFLV114569617(kdm8)
GAT120827473(kdm8)
PPUG119220237(kdm8)
AFB129098693(kdm8)
CLUM117734850(kdm8)
MSAM119891795(kdm8)
SCHU122868852(kdm8)
CUD121529529(kdm8)
ALAT119014793(kdm8)
MZE101485357(kdm8)
ONL100699006(kdm8)
OAU116318409(kdm8)
OLA101171915(kdm8)
OML112146982(kdm8)
XMA102233051(kdm8)
XCO114159963(kdm8)
XHE116735242(kdm8)
PRET103468686(kdm8)
PFOR103143790(kdm8)
PLAI106962172(kdm8)
PMEI106933564(kdm8)
GAF122821497(kdm8)
PPRL129352489(kdm8)
CVG107083042(kdm8)
CTUL119785260(kdm8)
GMU124862529 124864575
NFU107378405(kdm8)
KMR108243702(kdm8)
ALIM106528620(kdm8)
NWH119421778(kdm8)
AOCE111576709(kdm8)
MCEP124997933(kdm8)
CSEM103392783(kdm8)
POV109646144(kdm8)
SSEN122785913(kdm8)
HHIP117766509(kdm8)
HSP118122811(kdm8)
LCF108903012
SDU111217654(kdm8)
SLAL111660457(kdm8)
XGL120805448(kdm8)
HCQ109513772(kdm8)
SSCV125984004
SBIA133515099(kdm8)
PEE133414997(kdm8)
PTAO133466544(kdm8)
BPEC110169515(kdm8)
MALB109965878(kdm8)
BSPL114861001(kdm8)
SJO128379592(kdm8)
SASA106601109(kdm8)
STRU115171177 115171181
OTW112245983
OMY110486318 110538261(kdm8)
OGO123999647 124015143
ONE115104188 115110329
OKI109893381 109898464
OKE118365319 118365321
SALP111981712(kdm8)
SNH120034077 120036526
CCLU121550743
ELS105013404(kdm8)
SFM108932965(kdm8)
PKI111846408(kdm8)
AANG118216971(kdm8)
LOC102685265(kdm8)
PSPA121331140(kdm8)
ARUT117417669(kdm8)
PSEX120543205(kdm8)
LCM102360974(KDM8)
CMK103186634(kdm8)
RTP109919240(kdm8)
CPLA122560711(kdm8)
HOC132825207(kdm8)
LERI129706790(kdm8)
PMRN116939326(KDM8)
LRJ133346946 133346955
BFO118421565
BBEL109478839 109482651
CIN100181325
SCLV120335524
SPU588873
APLC110976329
AJC117106651
SKO100372959
DMEDmel_CG13902(JMJD5)
DER6545200
DSE6610238
DSIDsimw501_GD13505(Dsim_GD13505)
DYADyak_GE16565
DAN6507650
DSR110183689
DPO4812860
DPE6602792
DMN108151792
DWI6645351
DGR6556951
DMODmoj_GI12291
DAZ108613892
DNV108651897
DHE111598686
DVI6622966
CCAT101456937
BOD106627463
BDR105224428
RZE108375597
AOQ129241029
TDA119667166
MDE101900399
SCAC106095075
LCQ111676890
LSQ119605865
GFS119631814
ECOE129945943
CLON129611375
HIS119648741
ACOZ120956201
AARA120902932 120905221
AMER121599244 121601323
ASTE118506067 118516513
AMOU128297526
AALI118466013
AAG5564719
AALB109412923 109418692 115257489
CQUCpipJ_CPIJ014507
CPII120420386
CNS116337752
BCOO119072032
AME113218746
ALAB122719926
ADR102671326
AFLR105735767
BIM100744355
BBIF117204175
BVK117235669
BVAN117159615
BTER100651753
BAFF126914216
BPYO122566880
BPAS132909829
FVI122537959
CCAL108626095
OBB114872254
OLG117601742
MGEN117220858
NMEA116427275
CGIG122401891
SOC105201769
MPHA105837308
AEC105154667
ACEP105622456
VEM105564685
HST105190373
DQU106748539
CFO105258173
FEX115246270
LHU105672210
PGC109858284
OBO105276372
PCF106789627
PFUC122513485
VPS122636951
VCRB124430945
VVE124957098
NVI100119757
CSOL105362552
TPRE106653971
LHT122504840
LBD127279015
MDL103577029
CGLO123270540
FAS105264970
DAM107042978
AGIF122848106
CINS118074198
VCAN122406808
CCIN107265200
DSM124413126
NPT124216920
NFB124174609 124178025
NLO107221835
NVG124310173
AROA105688592
DPA109546871
SOY115887344
AGRG126736485
ATD109596736
CSET123307462
AGB108914433
LDC111510692
NVL108563738
APLN108741443
PPYR116180519
OTU111427466
BMOR101745348
BMAN114239629
MSEX115450831
DPLKGM_210029
BANY112048841
MJU123866868
NIQ126768675
VCD124530746
MCIX123654228
PMAC106715999
PPOT106101601
PXU106125375
PRAP110997923
PBX123708848
PNAP125050959
ZCE119831437
CCRC123692319
LSIN126977411
HAW110374823
HZE124630397
TNL113502402
SLIU111349763
OFU114351777
PXY105395542
PGW126367060
CFEL113386348
CCRN123297972
API100165392
DNX107173374
AGS114128232
RMD113549050
ACOO126838088
DVT126900348
DCI103505186 103505188
CLEC106669245
HHAL106686020
NLU111044088
HVI124372633 124373171
MQU129002717
PHUPhum_PHUM596820
FOC113205536
TPAL117644597
ZNE110839876
CSEC111874065
SGRE126336936
IEL124163975
FCD110846724
DPXDAPPUDRAFT_303848
PJA122260037
PCHN125041730
PMOO119581963
CQD128689239
PTRU123520077
ESN126981080
EAF111694870
LSM121126475
TCF131885437
PPOI119101632
DSV119436642
RSAN119395735
RMP119159767
VDE111252366
VJA111259927
DPTE113788978
DFR124490473
CSCU111618703
PTEP107447807
UDV129227336
SDM118188217
LPOL106459220
PMEO129598714
CELCELE_C06H2.3(jmjd-5)
CBRCBG_23111(Cbr-jmjd-5)
CRQGCK72_016633
BMYBM_BM2032(Bma-jmjd-5)
LOALOAG_05299
TSPTsp_13181
HROHELRODRAFT_161296
LGILOTGIDRAFT_142327
PVUL126811739
PCAN112576436
BGT106058226
GAE121388728
HRF124140253
HRJ124259390
CRG105345284
CVN111133986
CANU128188262
OED125648728
MYI110463484
PMAX117337730
MCAF127702348
MMER123549031
RPHI132742490
DPOL127846572
OBI106876462
OSN115221011 115229362
LAK106174715
SMMSmp_128500
OVIT265_06908
EGLEGR_07691
NVE5516693
EPA110239889
ATEN116304615
AMIL114975733
PDAM113669955
SPIS111324529
DGT114533640
XEN124439149
HMG100203259
HSY130640744 130641123
TADTRIADDRAFT_21598
AQU100634736
DDIDDB_G0270906(jcdD)
DPPDICPUDRAFT_91588
DFADFA_08281(jcdD)
ACANACA1_337970
AAFAURANDRAFT_27076
PIFPITG_01066
PSOJPHYSODRAFT_472104
SPARSPRG_05119
EHXEMIHUDRAFT_213927
GTTGUITHDRAFT_64747
NGRNAEGRDRAFT_68331
MSTOMSTO_01620
 » show all
Reference
1  [PMID:29563586]
  Authors
Wilkins SE, Islam MS, Gannon JM, Markolovic S, Hopkinson RJ, Ge W, Schofield CJ, Chowdhury R
  Title
JMJD5 is a human arginyl C-3 hydroxylase.
  Journal
Nat Commun 9:1180 (2018)
DOI:10.1038/s41467-018-03410-w
  Sequence
[hsa:79831]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.73
IUBMB Enzyme Nomenclature: 1.14.11.73
ExPASy - ENZYME nomenclature database: 1.14.11.73
BRENDA, the Enzyme Database: 1.14.11.73

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