Entry
Name
L-isoleucine 31-dioxygenase;
hilA (gene name);
L-isoleucine 4'-dioxygenase (incorrect)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
L-isoleucine,2-oxoglutarate:oxygen oxidoreductase (31-hydroxylating)
Reaction(IUBMB)
L-isoleucine + 2-oxoglutarate + O2 = 31-hydroxy-L-isoleucine + succinate + CO2 [RN:
R12650 ]
Reaction(KEGG)
Substrate
Product
31-hydroxy-L-isoleucine;
succinate [CPD:
C00042 ];
CO2 [CPD:
C00011 ]
Comment
Requires Fe2+ and ascorbate. The enzyme has been characterized from the bacterium Pantoea ananatis.
History
EC 1.14.11.74 created 2020
Orthology
K24448 L-isoleucine 31-dioxygenase
Genes
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Taxonomy
Reference
Authors
Smirnov SV, Sokolov PM, Kotlyarova VA, Samsonova NN, Kodera T, Sugiyama M, Torii T, Hibi M, Shimizu S, Yokozeki K, Ogawa J
Title
A novel l-isoleucine-4'-dioxygenase and l-isoleucine dihydroxylation cascade in Pantoea ananatis.
Journal
Sequence
Other DBs