Entry
Name
31-hydroxy-L-isoleucine 4-dioxygenase;
hilB (gene name);
4'-hydroxy-L-isoleucine 4-dioxygenase (incorrect)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
31-hydroxy-L-isoleucine,2-oxoglutarate:oxygen oxidoreductase (4S-hydroxylating)
Reaction(IUBMB)
31-hydroxy-L-isoleucine + 2-oxoglutarate + O2 = (4S)-31,4-dihydroxy-L-isoleucine + succinate + CO2 [RN:
R12651 ]
Reaction(KEGG)
Substrate
31-hydroxy-L-isoleucine;
2-oxoglutarate [CPD:
C00026 ];
O2 [CPD:
C00007 ]
Product
Comment
Requires Fe2+ and ascorbate. The enzyme has been characterized from the bacterium Pantoea ananatis.
History
EC 1.14.11.75 created 2020
Orthology
K24449 31-hydroxy-L-isoleucine 4-dioxygenase
Genes
» show all
Taxonomy
Reference
Authors
Smirnov SV, Sokolov PM, Kotlyarova VA, Samsonova NN, Kodera T, Sugiyama M, Torii T, Hibi M, Shimizu S, Yokozeki K, Ogawa J
Title
A novel l-isoleucine-4'-dioxygenase and l-isoleucine dihydroxylation cascade in Pantoea ananatis.
Journal
Sequence
Other DBs