KEGG   ENZYME: 1.14.11.80
Entry
EC 1.14.11.80               Enzyme                                 
Name
methylcytosine dioxygenase;
TET1 (gene name);
TET2 (gene name);
TET3 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
5-methylcytosine in DNA,2-oxoglutarate:oxygen oxidoreductase
Reaction(IUBMB)
(1) 5-methylcytosine in DNA + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine in DNA + succinate + CO2 [RN:R11030];
(2) 5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2 = 5-formylcytosine in DNA + succinate + CO2 + H2O [RN:R13108];
(3) 5-formylcytosine in DNA + 2-oxoglutarate + O2 = 5-carboxycytosine in DNA + succinate + CO2 [RN:R13109]
Reaction(KEGG)
R11030 R13108 R13109
Substrate
5-methylcytosine in DNA [CPD:C02967];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007];
5-hydroxymethylcytosine in DNA [CPD:C21031];
5-formylcytosine in DNA [CPD:C22620]
Product
5-hydroxymethylcytosine in DNA [CPD:C21031];
succinate [CPD:C00042];
CO2 [CPD:C00011];
5-formylcytosine in DNA [CPD:C22620];
H2O [CPD:C00001];
5-carboxycytosine in DNA [CPD:C22621]
Comment
The TET proteins mediate iterative oxidation of 5-methylcytosine in DNA (5mc) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). 5fC and 5caC are recognized by EC 3.2.2.29, thymine-DNA glycosylase (TDG), which excises them, leaving an apyrimidinic site. Coupled with the base excision repair (BER) pathway, these activities result in a cytosine demethylation pathway.
History
EC 1.14.11.80 created 2022
Orthology
K13097  methylcytosine dioxygenase
K24309  methylcytosine dioxygenase TET2/3
Genes
HSA: 200424(TET3) 54790(TET2) 80312(TET1)
PTR: 450497(TET1) 459329(TET3) 471263(TET2)
PPS: 100967275(TET3) 100985863(TET2) 100994141(TET1)
GGO: 101128074(TET2) 101140089(TET3) 101154365(TET1)
PON: 100437556(TET1) 100438711(TET2) 100442848(TET3)
NLE: 100582842(TET3) 100600438(TET1) 100604843(TET2)
HMH: 116458720(TET1) 116481641(TET2) 116482961(TET3)
MCC: 693707(TET1) 694137(TET2) 707759(TET3)
MCF: 102122605(TET1) 102122788(TET2) 102146434(TET3)
MTHB: 126934006 126955177 126963154
MNI: 105465279(TET3) 105466117(TET1) 105486308(TET2)
CSAB: 103216093(TET1) 103220042(TET3) 103236067(TET2)
CATY: 105571392(TET2) 105596851(TET3) 105597454(TET1)
PANU: 101000648(TET1) 101007292(TET2) 101013148(TET3)
TGE: 112604691(TET3) 112625297(TET2) 112631203(TET1)
MLEU: 105529230(TET2) 105540181(TET3) 105549509(TET1)
RRO: 104668766(TET2) 104671664(TET1) 104676849(TET3)
RBB: 108514903(TET1) 108521863(TET3) 108529613(TET2)
TFN: 117062039(TET3) 117082205(TET1) 117085734(TET2)
PTEH: 111523395(TET3) 111537923(TET1) 111547985(TET2)
CANG: 105501199(TET1) 105512694(TET2) 105514584(TET3)
CJC: 100391032(TET1) 100403244(TET3) 100407516(TET2)
SBQ: 101028390(TET2) 101028776(TET3) 101044521(TET1)
CIMI: 108289292(TET3) 108294843(TET2) 108318148
CSYR: 103259604(TET2) 103266741(TET3) 103277271(TET1)
MMUR: 105870223(TET1) 105879045(TET2) 105884598(TET3)
LCAT: 123627712(TET2) 123637065(TET3) 123650420(TET1)
PCOQ: 105818946(TET2) 105821504(TET3) 105821749(TET1)
OGA: 100945378(TET3) 100948153(TET1) 100954211(TET2)
MMU: 194388(Tet3) 214133(Tet2) 52463(Tet1)
MCAL: 110291600(Tet2) 110296048(Tet3) 110303891(Tet1)
MPAH: 110316501(Tet3) 110320561(Tet2) 110326536(Tet1)
RNO: 309902(Tet1) 310859(Tet2) 680576(Tet3)
MCOC: 116074342(Tet1) 116093808(Tet2) 116099138(Tet3)
ANU: 117707642(Tet2) 117714753(Tet3) 117724126(Tet1)
MUN: 110557208(Tet1) 110562569(Tet2) 110566855(Tet3)
CGE: 100769509(Tet3) 100769811(Tet2) 100771765(Tet1)
MAUA: 101835496(Tet3) 101839115(Tet1) 101841649(Tet2)
PROB: 127222986(Tet2) 127224046(Tet1) 127235602(Tet3)
PLEU: 114683043(Tet2) 114694408(Tet3) 114701137(Tet1)
MORG: 121440502(Tet3) 121447231(Tet2) 121450916(Tet1)
MFOT: 126499762 126501692 126515313
AAMP: 119800883(Tet2) 119806520(Tet3) 119823886(Tet1)
NGI: 103733758(Tet1) 103740608(Tet2) 103749944(Tet3)
HGL: 101703231(Tet1) 101710771(Tet3) 101722412(Tet2)
CPOC: 100715975(Tet3) 100718966(Tet1) 100733403(Tet2)
CCAN: 109688138(Tet3) 109695221(Tet1) 109698496(Tet2)
DORD: 105986303(Tet1) 105991234(Tet2) 105999582(Tet3)
DSP: 122122308(Tet1) 122125142(Tet3) 122127115(Tet2)
PLOP: 125341376(Tet2) 125346385(Tet1) 125356353(Tet3)
NCAR: 124963059 124985301 124994426
MMMA: 107141363(Tet2) 107154210(Tet3) 107154838(Tet1)
OCU: 100339579 100347430 100350148
OPI: 101528499(TET2) 101532955(TET3) 101536242(TET1)
TUP: 102476879(TET2) 102477884(TET3) 102498328(TET1)
GVR: 103585990(TET1) 103596287(TET3) 103606341
CFA: 478499(TET2) 479229(TET1) 483109(TET3)
CLUD: 112644428(TET2) 112651253(TET1) 112664232(TET3)
VVP: 112916731(TET3) 112923783(TET1) 112934197(TET2)
VLG: 121488027(TET1) 121491681(TET3) 121493169(TET2)
NPO: 129501279(TET3) 129509780(TET1) 129521186(TET2)
AML: 100469957(TET2) 100477952(TET1) 100480248(TET3)
UMR: 103661712(TET2) 103667771(TET1) 103671399(TET3)
UAH: 113243822(TET3) 113255522(TET2) 113259114(TET1)
UAR: 123782899(TET1) 123786066(TET3) 123793396(TET2)
ELK: 111144966 111148027 111153570
LLV: 125084934 125093241 125108351
MPUF: 101670989(TET3) 101674304(TET2) 106003357
MNP: 132001876(TET2) 132016327(TET1) 132021442(TET3)
MLK: 131828896(TET1) 131829689(TET2) 131840313(TET3)
NVS: 122889310(TET2) 122900734(TET1) 122914996(TET3)
ORO: 101374488(TET3) 101378267(TET2) 101378605(TET1)
EJU: 114214182(TET1) 114218880(TET3) 114222638(TET2)
ZCA: 113919689(TET1) 113924553(TET2) 113937742(TET3)
MLX: 118007964(TET3) 118018005 118018781 118027062(TET2)
NSU: 110572149(TET2) 110588865(TET3) 110589453(TET1)
LWW: 102725807(TET3) 102732816(TET2) 102734137(TET1)
FCA: 101083580(TET3) 101091562(TET1) 101092848(TET2)
PYU: 121019242(TET3) 121031695(TET2) 121036709(TET1)
PCOO: 112854753(TET1) 112858890(TET2) 112869209(TET3)
PBG: 122477856(TET2) 122492821(TET1) 122497026(TET3)
PVIV: 125148203(TET1) 125162420(TET3) 125163550(TET2)
LRUF: 124503768 124506854 124520143
PTG: 102959541(TET1) 102960254(TET3) 102960342(TET2)
PPAD: 109247616(TET2) 109262972(TET3) 109264335(TET1)
PUC: 125922984 125932682 125937119
AJU: 106966496 106967141 106967737
HHV: 120232488(TET1) 120236995(TET3) 120247616(TET2)
BTA: 101904937(TET3) 513640(TET1) 538481(TET2)
BOM: 102272998(TET1) 102276920(TET3) 102287204(TET2)
BIU: 109553624(TET1) 109560281(TET2) 109565923(TET3)
BBUB: 102396328(TET1) 102398208(TET3) 102405717(TET2)
BBIS: 104980993(TET3) 104994622(TET2) 104997447(TET1)
CHX: 102184732(TET3) 102186373(TET1) 102191595(TET2)
OAS: 101103534(TET1) 101104996(TET2) 101105649(TET3)
BTAX: 128047853(TET1) 128049838(TET2) 128056499(TET3)
ODA: 120851232(TET3) 120861760(TET2) 120865194(TET1)
CCAD: 122422368(TET2) 122441496(TET3) 122446483(TET1)
MBEZ: 129539962(TET3) 129555778(TET1) 129561884(TET2)
SSC: 100520484(TET3) 100521465(TET2) 100625859(TET1)
CFR: 102506052(TET2) 102506860(TET3) 102511955(TET1)
CBAI: 105066365(TET1) 105066986(TET3) 105067925(TET2)
CDK: 105089572(TET2) 105093883(TET1) 105096566(TET3)
VPC: 102538207(TET2) 102542409(TET1) 102543706(TET3)
BACU: 102998384(TET3) 103004922(TET1) 103014051(TET2)
BMUS: 118883050(TET1) 118895456(TET2) 118905887(TET3)
LVE: 103076185 103079040(TET3) 103090176(TET2)
OOR: 101270552(TET3) 101272595(TET2) 101275716(TET1)
DLE: 111169121(TET3) 111171470(TET2) 111183443(TET1)
PCAD: 102978846(TET3) 102982309(TET2) 102988205(TET1)
PSIU: 116742008(TET1) 116753870(TET2) 116764561(TET3)
NASI: 112404073(TET2) 112413578(TET1) 112413633(TET3)
ECB: 100057820(TET3) 100072632(TET1) 100073065(TET2)
EPZ: 103557579(TET1) 103558398(TET2) 103559864(TET3)
EAI: 106823862(TET3) 106842085(TET2) 106845001(TET1)
MYB: 102255490(TET3) 102261023(TET1) 102261093(TET2)
MYD: 102756019(TET3) 102761585(TET1) 102773712(TET2)
MMYO: 118668842(TET3) 118670330 118673465(TET2)
MLF: 102419990(TET1) 102424636(TET3) 102427377(TET2)
PKL: 118703232(TET2) 118717550(TET3) 118719003(TET1)
EFUS: 103289600(TET1) 103291411(TET3) 103293858(TET2)
MNA: 107526041(TET1) 107529266(TET3) 107545507(TET2)
DRO: 112302954(TET3) 112305623(TET1) 112317846(TET2)
SHON: 118975370(TET1) 118977172(TET2) 119000079(TET3)
AJM: 119038161(TET1) 119038419(TET3) 119056127(TET2)
PDIC: 114491415(TET2) 114497399(TET1) 114499427(TET3)
PHAS: 123806764(TET2) 123812017(TET3) 123821067(TET1)
MMF: 118624783(TET2) 118630919(TET3) 118632499(TET1)
PPAM: 129069789(TET1) 129085313(TET2) 129086836(TET3)
HAI: 109371211(TET3) 109372700(TET1) 109377031(TET2)
RFQ: 117022137(TET2) 117032773(TET3) 117036040(TET1)
PALE: 102883587(TET2) 102884458(TET3) 102897200(TET1)
PGIG: 120591192(TET2) 120594545(TET3) 120609448(TET1)
PVP: 105290748(TET3) 105293020(TET2) 105300099(TET1)
RAY: 107501310(TET1) 107502894(TET3) 107512419(TET2)
MJV: 108386480(TET3) 108396733(TET1) 108397333(TET2)
TOD: 119234554(TET1) 119243663(TET2) 119259081(TET3)
SARA: 101544370(TET1) 101545360(TET3) 101557265(TET2)
LAV: 100671009(TET3) 100674717(TET2) 100675001(TET1)
TMU: 101350164 101361786 101362070
ETF: 101640209(TET3) 101642759(TET2) 101657294(TET1)
DNM: 101417608(TET3) 101433103(TET1) 101443359(TET2)
MDO: 100013110(TET2) 100014701(TET1) 100617359(TET3)
GAS: 123233032(TET1) 123233070(TET3) 123252900(TET2)
SHR: 100914493(TET2) 100916608(TET3) 100919541(TET1)
AFZ: 127542016 127547320 127552102
PCW: 110199787(TET2) 110200064(TET1) 110222636(TET3)
OAA: 100079592(TET2) 100091768(TET1) 103167955(TET3)
GGA: 422540(TET2) 423690(TET1) 425829(TET3)
PCOC: 116234497(TET3) 116235004(TET1) 116238103(TET2)
MGP: 100539143(TET3) 100541560(TET1) 100544333(TET2)
CJO: 107313300(TET2) 107315707(TET1) 107323691(TET3)
TPAI: 128071867(TET3) 128078097(TET1) 128079861(TET2)
LMUT: 125685231(TET3) 125692092(TET2) 125692863(TET1)
NMEL: 110387222(TET3) 110397478(TET2) 110399228(TET1)
APLA: 101797266(TET2) 101797987(TET1) 119713564(TET3)
ACYG: 106030964(TET1) 106045311(TET2) 106047649(TET3)
CATA: 118244814(TET2) 118249363(TET1) 118259339(TET3)
AFUL: 116488539(TET2) 116491100(TET1) 116499295(TET3)
TGU: 100218736(TET1) 100228365(TET2) 115498126(TET3)
LSR: 110469879(TET1) 110471159(TET2) 110480184(TET3)
SCAN: 103821156(TET1) 103824907(TET3) 103826019(TET2)
PMOA: 120496107(TET1) 120499142(TET3) 120499736(TET2)
OTC: 121339046(TET3) 121346575(TET2) 121348061(TET1)
PRUF: 121355603(TET3) 121362610(TET2) 121365692(TET1)
GFR: 102036059(TET1) 102037031(TET2) 102044775(TET3)
FAB: 101813234(TET1) 101817204(TET2) 101822076(TET3)
OMA: 130252139(TET2) 130254837(TET1) 130261909(TET3)
PHI: 102105215(TET3) 102107468(TET2) 102113398(TET1)
PMAJ: 107199274(TET3) 107202979(TET2) 107206742(TET1)
CCAE: 111927752(TET2) 111931501(TET1) 111938773(TET3)
CCW: 104683770(TET3) 104690152(TET1) 104697108(TET2)
CBRC: 103617320(TET2) 103623624(TET1)
ETL: 114060749(TET2) 114066280(TET1) 114071512(TET3)
ZAB: 102065475(TET1) 102069996(TET2)
ACHL: 103800068 103805089(TET2)
SVG: 106854393(TET2) 106857302(TET1) 106862863(TET3)
MMEA: 130580380(TET1) 130581233(TET2) 130584217(TET3)
HRT: 120752764(TET2) 120755597(TET1) 120764031(TET3)
FPG: 101913593(TET3) 101913943(TET2) 101919711(TET1)
FCH: 102046196(TET3) 102047169(TET2) 102056076(TET1)
CLV: 102089745(TET3) 102089841(TET1) 102095484(TET2)
EGZ: 104124627(TET1) 104126583(TET2) 104130376(TET3)
NNI: 104013483(TET1) 104021176(TET2)
PCRI: 104025635(TET1) 104030437(TET2)
PLET: 104619536(TET1) 104620864(TET2)
EHS: 104510901(TET1)
PCAO: 104043512 104049477(TET2)
ACUN: 113479521(TET2) 113481840(TET1) 113488026
TALA: 104361177(TET1) 104366475(TET2) 116959725(TET3)
PADL: 103918484(TET1) 103919528(TET2)
AFOR: 103894223(TET2) 103905220(TET3) 103908202(TET1)
ACHC: 115343343(TET2) 115347979(TET1) 115350363(TET3)
HALD: 104312072(TET1) 104319322(TET2)
HLE: 104829018(TET3) 104839591(TET1) 104843328(TET2)
AGEN: 126042642 126045016 126051735
GCL: 127015480 127017542 127025226
CCRI: 104156145(TET1) 104169051(TET2)
CSTI: 104560235(TET1) 104564023(TET2)
CMAC: 104484543(TET1) 104485684(TET2)
MUI: 104535233 104547379(TET2)
BREG: 104637006(TET2) 104643006(TET1)
FGA: 104073526(TET1) 104074867(TET2)
GSTE: 104259158(TET1) 104260861(TET2)
LDI: 104352006(TET1) 104353898(TET2)
MNB: 103771187 103774983
OHA: 104338393(TET1) 104339124(TET2)
NNT: 104401976(TET1) 104404004(TET2)
SHAB: 115608169(TET1) 115610369(TET2) 115618360(TET3)
DPUB: 104301807(TET2) 104306168(TET1)
PGUU: 104469017(TET2) 104471706(TET1)
ACAR: 104523951(TET2) 104532957
CPEA: 104386299(TET1) 104393647(TET2)
AVIT: 104269294 104271454(TET2)
CVF: 104286857(TET2) 104294302(TET1)
RTD: 128903904(TET3) 128909886(TET2) 128911141(TET1)
CUCA: 104062873(TET2) 104065470(TET3) 104065665(TET1)
TEO: 104370857 104374820(TET2)
BRHI: 104491290(TET1) 104493639(TET2)
AAM: 106486962(TET1) 106492014(TET2)
AROW: 112963152(TET1) 112972180(TET2)
NPD: 112950025 112950202(TET1) 112957280(TET2)
TGT: 104578297(TET2) 104580165(TET1)
DNE: 112986863(TET1) 112988376(TET2)
SCAM: 104144673(TET1) 104153454(TET2)
ASN: 102368709(TET2) 102380670(TET3) 102387642(TET1)
AMJ: 102559455(TET1) 102564733(TET2) 102575499(TET3)
CPOO: 109309417(TET2) 109312461(TET1) 109317289(TET3)
GGN: 109290916(TET1) 109295505(TET3) 109301046(TET2)
PSS: 102453997(TET3) 102462102(TET2) 102462678(TET1)
CMY: 102930294(TET3) 102932494(TET1) 102946068(TET2)
CCAY: 125626362(TET3) 125635251(TET2)
DCC: 119848649(TET3) 119854395(TET2) 119858487(TET1)
CPIC: 101930793(TET3) 101939735(TET1) 101946912(TET2)
TST: 117872889(TET3) 117877611(TET2) 117881014(TET1)
CABI: 116821202(TET3) 116833048(TET2) 116833613(TET1)
MRV: 120368680(TET1) 120397188(TET3) 120406326(TET2)
ACS: 100552284(tet2) 100555822(tet3) 107983127
ASAO: 132771193(TET1) 132776950(TET2) 132782284(TET3)
PVT: 110072087(TET3) 110080471(TET2) 110086794(TET1)
SUND: 121926392(TET1) 121930501(TET2) 121932618(TET3)
PBI: 103048985(TET1) 103054028(TET3) 103057861(TET2)
PMUR: 107283256(TET3)
CTIG: 120299356(TET3) 120299629(TET1) 120308235(TET2)
TSR: 106546441(TET1) 106552164(TET3)
PGUT: 117673325(TET3) 117678003(TET1) 117679906(TET2)
APRI: 131200647(TET1) 131202940(TET2) 131204017(TET3)
PTEX: 113434810(TET2) 113444649(TET1) 113445766(TET3)
NSS: 113412812(TET2) 113415410(TET1) 113423394(TET3)
VKO: 123016824(TET3) 123018400(TET1) 123023180(TET2)
PMUA: 114597192(TET1) 114602655(TET3) 114603859(TET2)
PRAF: 128413914(TET1) 128420063(TET3) 128421299(TET2)
ZVI: 118083422(TET2) 118087968(TET3) 118096505(TET1)
HCG: 128326307(TET2) 128333736(TET3) 128350193(TET1)
GJA: 107112689(TET1) 107120329(TET3) 107125656(TET2)
STOW: 125437904(TET1) 125440120(TET2) 125441433(TET3)
EMC: 129331663(TET1) 129336874(TET2) 129341961(TET3)
XLA: 108706731(tet2.S) 108710731(tet2.L) 108711530(tet3.L) 108712780(tet3.S)
XTR: 100036628(tet3) 100380145(tet2)
NPR: 108785428(TET2) 108793891(TET3)
RTEM: 120918221(TET2) 120931049(TET3)
BBUF: 120986074(TET3) 120989870(TET2)
BGAR: 122927454(TET3) 122944354(TET2)
MUO: 115461156(TET2) 115469289(TET3) 115471269(TET1)
GSH: 117358823(TET1) 117362931(TET3) 117365856(TET2)
DRE: 101883702(tet1) 101887161(tet2) 103283056(tet3)
SRX: 107708251 107708452 107714646 107747454 107757629
SANH: 107654213 107678588 107690175 107695330 107697244 107700324
SGH: 107551814 107557386 107582512 107589523 107595052 107598249
CCAR: 109052757 109101144 109108305
CAUA: 113044437(tet2) 113057164 113071276 113071686 113108593 113112936
CGIB: 127950932 127957065 127969921 128013720 128026402 128028902
PTET: 122341477(tet2) 122345953(tet3) 122356542(tet1)
LROH: 127165255(tet3) 127172079(tet2) 127175164(tet1)
OMC: 131537146(tet2) 131540287(tet3) 131551813(tet1)
PPRM: 120470439(tet3) 120479303(tet1) 120494984(tet2)
RKG: 130083099(tet1) 130088077(tet3) 130099433(tet2)
MAMB: 125267359(tet3) 125272401(tet2) 125276628(tet1)
CIDE: 127509840 127512813
MASI: 127412013 127414011 127425280 127438228 127443679 127445141
TROS: 130551417(tet3) 130552443(tet2) 130559588(tet1)
TDW: 130418875(tet3) 130432057(tet1) 130433988(tet2)
MANU: 129415640(tet1) 129439748(tet3) 129444573(tet2)
IPU: 108255510 108263573 108263772
IFU: 128605531 128606156(tet2) 128625503(tet3)
PHYP: 113524609(tet2) 113536954(tet3) 113539835
SMEO: 124376472(tet1) 124380415(tet3) 124396260(tet2)
TFD: 113639797(tet1) 113657096(tet2) 113657198(tet3)
TVC: 132847229(tet1) 132847740(tet2) 132855401(tet3)
AMEX: 103033153(tet1) 103046012 103046434(tet2)
CMAO: 118810331(tet1) 118810755(tet2) 118826856(tet3)
EEE: 113585328(tet2) 113587361 113587604
CHAR: 105890015(tet3) 105903989(tet2) 105909953(tet1)
TRU: 101065346 101068038 101073625(tet2)
TFS: 130526305(tet3) 130527067(tet2) 130533605(tet1)
TNG: GSTEN00016497G001 GSTEN00031114G001
LCO: 104925995(tet3) 104926967(tet2) 104930132
NCC: 104946267 104965096(tet2)
TBEN: 117481665(tet2) 117496954(tet3) 117499615(tet1)
CGOB: 115014035(tet3) 115015344(tet2) 115019750
PGEO: 117449520(tet2) 117452092(tet3) 117459736(tet1)
GACU: 117538195(tet1) 117553111(tet3) 117555303(tet2)
EMAC: 134858447(tet1) 134864278(tet2) 134873461(tet3)
ELY: 117248806(tet1) 117252988(tet3) 117255249(tet2)
EFO: 125885386(tet2) 125889715(tet3) 125903330(tet1)
PLEP: 121941816(tet2) 121944609(tet3) 121954351(tet1)
SLUC: 116034366(tet2) 116050487(tet3) 116054055(tet1)
ECRA: 117937173(tet2) 117945522(tet3) 117960143(tet1)
ESP: 116690050 116697744(tet2) 116704931
PFLV: 114555176 114568827(tet2) 114572644(tet1)
GAT: 120820909(tet1) 120825864(tet2) 120830296(tet3)
PPUG: 119213985(tet1) 119217628(tet2) 119224959(tet3)
AFB: 129091947(tet1) 129095825(tet2) 129101347(tet3)
CLUM: 117735693(tet2) 117736449(tet3) 117743821(tet1)
PSWI: 130190495(tet2) 130196463(tet3) 130206883(tet1)
MSAM: 119891294(tet3) 119898929(tet2) 119916904(tet1)
SCHU: 122872946(tet2) 122876524(tet3) 122884910(tet1)
CUD: 121508056(tet2) 121509457(tet3) 121511061(tet1)
ALAT: 119018507(tet2) 119019374(tet3) 119033343(tet1)
MZE: 101464948 101470589(tet2) 101481549
ONL: 102079559(tet3) 102081773 102082021(tet2)
OAU: 116316631(tet1) 116325381(tet3) 116330005(tet2)
OLA: 101165814 101169512 101170986(tet2)
OML: 112148024(tet3) 112157114(tet2) 112162155(tet1)
CSAI: 133437351(tet2) 133451372(tet3) 133463991(tet1)
XMA: 102222313(tet3) 102236515(tet2) 106699700(tet1)
XCO: 114137933 114144979(tet2) 114154028(tet3)
XHE: 116712546(tet1) 116720652(tet2) 116730466(tet3)
PRET: 103466474(tet2) 103469756(tet3) 103476883
PFOR: 103146704(tet3) 103147714 103147743 103148478 103148482
PLAI: 106936827(tet3) 106940854 106955188(tet1) 106959448
PMEI: 106904236 106906237 106907602(tet1) 106908333 106925456(tet2)
GAF: 122828818(tet3) 122829015(tet2) 122843055(tet1)
PPRL: 129360010(tet1) 129367096(tet2) 129372925(tet3)
CVG: 107092736 107095860(tet2) 107101442
CTUL: 119788573(tet1) 119791135(tet3) 119796259(tet2)
GMU: 124859149(tet1) 124867810(tet2) 124877530(tet3)
NFU: 107375277(tet2) 107375701(tet1) 107393527(tet3)
KMR: 108230985(tet2) 108234976(tet3) 108244348(tet1)
ALIM: 106517051(tet2) 106524728(tet3) 106528603(tet1)
NWH: 119412355(tet1) 119414114(tet3) 119430751(tet2)
AOCE: 111564364 111567143(tet2) 111572277
MCEP: 125003651(tet2) 125011670(tet3) 125018638(tet1)
CSEM: 103383528(tet2) 103387319(tet1) 103397059 103397467
POV: 109633800(tet3) 109635625 109638351(tet2)
SSEN: 122770130(tet3) 122771245(tet2) 122781627(tet1)
HHIP: 117767377(tet3) 117771572(tet2) 117775330(tet1)
HSP: 118114908(tet3) 118118900(tet1) 118120914(tet2)
SMAU: 118283333(tet1) 118313216(tet2) 118313449(tet3)
LCF: 108878340 108884413 108896534
SDU: 111226959(tet3) 111235155(tet1) 111236619(tet2)
SLAL: 111647925(tet3) 111654651 111670419(tet2)
XGL: 120796461(tet1) 120800110(tet2) 120804943(tet3)
HCQ: 109509904 109511104(tet2) 109524987
SSCV: 125968399 125978679 125993881
SBIA: 133499571(tet3) 133505935 133509409(tet1)
PEE: 133400373(tet3) 133403541(tet2) 133409480(tet1)
PTAO: 133474694(tet3) 133476830(tet2) 133486016(tet1)
BPEC: 110163340 110164208 110165368(tet2)
MALB: 109954754 109961018(tet1) 109961312(tet2)
BSPL: 114861517(tet2) 114861909(tet3) 114870424(tet1)
SJO: 128365362(tet3) 128370085(tet2) 128372691(tet1)
SASA: 106577185 106580493 106585101 106602283 106610354 106613168
STRU: 115153373 115164298 115191710 115193563 115200351 115202312
OTW: 112241066(tet2) 112248648(tet3) 112253563 112256292(tet1) 112262693
OMY: 110497305(tet2) 110502641 110525859 110530841 110533203 110536245
OGO: 124001139(tet2) 124034168 124038367(tet1) 124041113
ONE: 115111770 115113089 115134959 115140236
OKI: 109879062 109881972 109882281 109894927 109899825 116373087
OKE: 118357874 118366110 118373700(tet2) 118380482 118393385
SALP: 111958050 111974813 111978183
SNH: 120017848 120035087(tet2) 120037635 120046715(tet1) 120063344(tet3)
CCLU: 121530650 121553401 121557063(tet2) 121567486 121585020
ELS: 105010609 105014352(tet3) 105021066(tet2)
SFM: 108920723 108924487(tet2) 108940376
PKI: 111837235(tet2) 111844155(tet3) 111849581
AANG: 118206231(tet3) 118217852(tet1) 118227299(tet2) 118231295
LOC: 102689575(tet3) 102689591(tet1) 102689863(tet2)
PSPA: 121302240 121303004(tet3) 121321870 121322046 121326180(tet1) 121327427
ARUT: 117397862 117408527 117415695 117418218 117421276 117966089
PSEX: 120532804(tet2)
LCM: 102346742(TET2) 102350737(TET3) 102366582(TET1)
CMK: 103177662 103182207(tet1) 103191015
RTP: 109927965
CPLA: 122543146(tet3) 122564906
HOC: 132825315 132837007(tet3)
LERI: 129695579 129713329
PMRN: 116950889
LRJ: 133354339
BFO: 118411024
BBEL: 109478275
CIN: 100181878
SCLV: 120347720
SPU: 580376
APLC: 110977987
SKO: 100366356
DME: Dmel_CG43444(Tet)
DER: 6546372
DSE: 6610523
DSI: Dsimw501_GD13372(Dsim_GD13372)
DYA: Dyak_GE21689
DAN: 6493110
DSR: 110185335
DPO: 6900088
DPE: 6599610
DMN: 108151565
DWI: 6639345
DGR: 6557193
DMO: Dmoj_GI13905
DAZ: 108613259
DNV: 108651546
DHE: 111597607
DVI: 6623063
CCAT: 101460073
BOD: 106618212
BDR: 105225149
RZE: 108359009
AOQ: 129243032
TDA: 119667643 119680104
MDE: 101900516
SCAC: 106095028
LCQ: 111674877
LSQ: 119607850
ECOE: 129944122
HIS: 119649277
AGA: 5667160
ACOZ: 120953591
AARA: 120908832
AMER: 121592909
ASTE: 118510262
AFUN: 125770622
AMOU: 128303589
AALI: 118467261
AAG: 5573007
AALB: 109422486 115262859
CQU: CpipJ_CPIJ009910
CPII: 120418658
CNS: 116350503
BCOO: 119079308
AME: 412878
ACER: 107995534
ALAB: 122712506
ADR: 102680417
AFLR: 100866593
BIM: 100742067
BBIF: 117210742
BVK: 117232268
BVAN: 117157851
BTER: 100642293
BAFF: 126921330
BPYO: 122573971
BPAS: 132916617
FVI: 122532787
CCAL: 108629950
OBB: 114879355
OLG: 117605643
MGEN: 117225819
NMEA: 116430872
CGIG: 122395997
SOC: 105201110
MPHA: 105832348
AEC: 105145855
ACEP: 105618945
PBAR: 105434147
VEM: 105570560
HST: 105189647
DQU: 106750706
CFO: 105258876
FEX: 115236392
LHU: 105670607
PGC: 109855178
OBO: 105283671
PCF: 106793296
PFUC: 122526086
VPS: 122632980
VCRB: 124428261
VVE: 124952807
NVI: 100114438
CSOL: 105362988
TPRE: 106660203
LHT: 122512715
LBD: 127289164
MDL: 103575228
CGLO: 123267057
FAS: 105266688
DAM: 107040167
AGIF: 122851822
CINS: 118073823
CCIN: 107274493
DSM: 124416660
NPT: 124210824
NFB: 124175539
NLO: 107221085
NVG: 124296972
TCA: 103312925
DPA: 109535782
SOY: 115876270
ATD: 109596041
CSET: 123310831
AGB: 108905769
LDC: 111508647
NVL: 108564764
APLN: 108734145
PPYR: 116170368
OTU: 111428051
BMOR: 101743969
BMAN: 114240805
MSEX: 115452729
DPL: KGM_210059
BANY: 112047331
MJU: 123866945
NIQ: 126768610
VCD: 124530202
MCIX: 123654186
PMAC: 106710979
PPOT: 106101320
PXU: 106125335
PRAP: 110993496
PBX: 123714034
PNAP: 125060502
ZCE: 119831339
CCRC: 123692444
LSIN: 126973095
HAW: 110374536(tet)
HZE: 124630237
TNL: 113502725
SLIU: 111349519
OFU: 114358184
PXY: 105385720
CCRN: 123297879
API: 100159694
DNX: 107173867
AGS: 114129200
RMD: 113554993
BTAB: 109029641
DCI: 103505818
CLEC: 106665216
NLU: 111058182
HVI: 124357290
PHU: Phum_PHUM059340
FOC: 113214477
TPAL: 117643904
ZNE: 110838460
CSEC: 111872603
SGRE: 126285408
IEL: 124161468
FCD: 110862326
DMK: 116917382
PVM: 113824054
PJA: 122242937
PCHN: 125026712
PMOO: 119580173
HAME: 121859110
PCLA: 123766499
PTRU: 123514607
ESN: 126995607
HAZT: 108667539
EAF: 111703686 111708890
DSV: 119436731
RSAN: 119396304
RMP: 119161275
CSCU: 111612732
PTEP: 107446842
SDM: 118188929 118200961
LPOL: 106458609
PCAN: 112563243
BGT: 106065605
GAE: 121378624
HRF: 124132607
HRJ: 124271982
CRG: 105322168
MYI: 110453899
PMAX: 117333895
MCAF: 127710228
MMER: 123564014
DPOL: 127869630
OBI: 106871070
OSN: 115213579
LAK: 106173631
NVE: 5514733
EPA: 110239364
ATEN: 116299108
ADF: 107350757
AMIL: 114946992
PDAM: 113671110
SPIS: 111344530
XEN: 124457572
HMG: 100213294
AQU: 100632527
 » show all
Reference
1  [PMID:20639862]
  Authors
Ito S, D'Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y.
  Title
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification.
  Journal
Nature 466:1129-33 (2010)
DOI:10.1038/nature09303
  Sequence
[mmu:52463 214133 194388]
Reference
2  [PMID:21778364]
  Authors
Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, He C, Zhang Y.
  Title
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.
  Journal
Science 333:1300-3 (2011)
DOI:10.1126/science.1210597
Reference
3  [PMID:21817016]
  Authors
He YF, Li BZ, Li Z, Liu P, Wang Y, Tang Q, Ding J, Jia Y, Chen Z, Li L, Sun Y, Li X, Dai Q, Song CX, Zhang K, He C, Xu GL.
  Title
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.
  Journal
Science 333:1303-7 (2011)
DOI:10.1126/science.1210944
Reference
4  [PMID:21862836]
  Authors
Maiti A, Drohat AC.
  Title
Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites.
  Journal
J Biol Chem 286:35334-35338 (2011)
DOI:10.1074/jbc.C111.284620
Reference
5  [PMID:22327402]
  Authors
Zhang L, Lu X, Lu J, Liang H, Dai Q, Xu GL, Luo C, Jiang H, He C.
  Title
Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA.
  Journal
Nat Chem Biol 8:328-30 (2012)
DOI:10.1038/nchembio.914
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.80
IUBMB Enzyme Nomenclature: 1.14.11.80
ExPASy - ENZYME nomenclature database: 1.14.11.80
BRENDA, the Enzyme Database: 1.14.11.80

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   KEGG GENES (1361)   
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