KEGG   ENZYME: 1.14.12.8
Entry
EC 1.14.12.8                Enzyme                                 
Name
4-sulfobenzoate 3,4-dioxygenase;
4-sulfobenzoate dioxygenase;
4-sulfobenzoate 3,4-dioxygenase system
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
Sysname
4-sulfobenzoate,NADH:oxygen oxidoreductase (3,4-hydroxylating, sulfite-forming)
Reaction(IUBMB)
4-sulfobenzoate + NADH + H+ + O2 = 3,4-dihydroxybenzoate + sulfite + NAD+ [RN:R01636]
Reaction(KEGG)
R01636
Substrate
4-sulfobenzoate [CPD:C02236];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
3,4-dihydroxybenzoate [CPD:C00230];
sulfite [CPD:C00094];
NAD+ [CPD:C00003]
Comment
A system, containing a reductase which is an iron-sulfur flavoprotein (FMN), an iron-sulfur oxygenase, and no independent ferredoxin. Requires Fe2+.
History
EC 1.14.12.8 created 1992
Pathway
ec00623  Toluene degradation
ec01120  Microbial metabolism in diverse environments
Reference
1  [PMID:2012609]
  Authors
Locher HH, Leisinger T, Cook AM.
  Title
4-Sulphobenzoate 3,4-dioxygenase. Purification and properties of a desulphonative two-component enzyme system from Comamonas testosteroni T-2.
  Journal
Biochem J 274 ( Pt 3):833-42 (1991)
DOI:10.1042/bj2740833
Other DBs
ExplorEnz - The Enzyme Database: 1.14.12.8
IUBMB Enzyme Nomenclature: 1.14.12.8
ExPASy - ENZYME nomenclature database: 1.14.12.8
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.8
BRENDA, the Enzyme Database: 1.14.12.8
CAS: 122933-81-7

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Enzyme (1)   
   UMBBD-EC (1)   
All databases (14)   

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