KEGG   ENZYME: 1.14.13.130
Entry
EC 1.14.13.130              Enzyme                                 
Name
pyrrole-2-carboxylate monooxygenase;
pyrrole-2-carboxylate oxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
pyrrole-2-carboxylate,NADH:oxygen oxidoreductase (5-hydroxylating)
Reaction(IUBMB)
pyrrole-2-carboxylate + NADH + H+ + O2 = 5-hydroxypyrrole-2-carboxylate + NAD+ + H2O [RN:R09586]
Reaction(KEGG)
R09586
Substrate
pyrrole-2-carboxylate [CPD:C05942];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
5-hydroxypyrrole-2-carboxylate [CPD:C19721];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). The enzyme initiates the degradation of pyrrole-2-carboxylate.
History
EC 1.14.13.130 created 2011
Reference
1  [PMID:8011178]
  Authors
Hormann K, Andreesen JR
  Title
Purification and characterization of a pyrrole-2-carboxylate oxygenase from Arthrobacter strain Py1.
  Journal
Biol Chem Hoppe Seyler 375:211-8 (1994)
Reference
2  [PMID:9395321]
  Authors
Becker D, Schrader T, Andreesen JR
  Title
Two-component flavin-dependent pyrrole-2-carboxylate monooxygenase from Rhodococcus sp.
  Journal
Eur J Biochem 249:739-47 (1997)
DOI:10.1111/j.1432-1033.1997.t01-1-00739.x
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.130
IUBMB Enzyme Nomenclature: 1.14.13.130
ExPASy - ENZYME nomenclature database: 1.14.13.130
BRENDA, the Enzyme Database: 1.14.13.130

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Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (18)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (15)   
DNA sequence (36)   
   RefSeq(nuc) (28)   
   GenBank (4)   
   EMBL (4)   
Protein domain (1)   
   InterPro (1)   
All databases (64)   

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