KEGG ENZYME: 1.14.13.148

ENZYME: 1.14.13.148

Entry

EC 1.14.13.148              Enzyme

Name

trimethylamine monooxygenase;
flavin-containing monooxygenase 3;
FMO3;
tmm (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

N,N,N-trimethylamine,NADPH:oxygen oxidoreductase (N-oxide-forming)

Reaction(IUBMB)

N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O [RN:R05623]

Reaction(KEGG)

R05623

Substrate

N,N,N-trimethylamine;
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]

Product

N,N,N-trimethylamine N-oxide;
NADP+ [CPD:C00006];
H2O [CPD:C00001]

Comment

A flavoprotein. The bacterial enzyme enables bacteria to use trimethylamine as the sole source of carbon and energy [1,4]. The mammalian enzyme is involved in detoxification of trimethylamine. Mutations in the human enzyme cause the inheritable disease known as trimethylaminuria (fish odor syndrome) [2,3].

History

EC 1.14.13.148 created 2012

Pathway

ec00680

Methane metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K18277

trimethylamine monooxygenase

Genes

STEK:

AXG53_01325

LCIC:

INQ41_07870

LAVI:

INQ42_07335

LUG:	FPZ22_13350

PMY:

Pmen_3459

PRE:	PCA10_14390

PFUW:

KF707C_42090

PCQ:	PcP3B5_34340(hapE_3)

PPG:	PputGB1_2270

PPUT:

L483_19090

PPUN:

PP4_21860

PFE:	PSF113_3540

PFS:

PFLU_2331

PMAN:

OU5_0413

PVR:	PverR02_12515

PBA:	PSEBR_a2220

PSV:	PVLB_12380

PSK:	U771_12125

PFZ:	AV641_09420

PLQ:	AA042_19100

PPSY:

AOC04_06155

PSET:

THL1_1501

PSIL:

PMA3_11125

PVK:	EPZ47_12030

PBZ:	GN234_06140

PKH:	JLK41_14790

PMAO:

PMYSY11_2269

PTRT:

HU722_0011560

PQI:	KH389_01330

PZA:	HU749_012830

PWY:	HU734_002510

PTAE:

NCTC10697_02640(hapE)

PKM:	PZ739_16185

PPAO:

K3169_15320

PBB:	AKN87_04520

HPEG:

EAO82_09950

DCE:	O6P33_02530

MBS:	MRBBS_3053

MPQ:	ABA45_14390

PSPG:

AK823_03630

PSYG:

AK825_03560

PSYC:

DABAL43B_0718

PCIA:

Q6344_03675

ALA:	BFG52_13560

ADV:	DJ533_05170

AWU:	BEN71_16350

ACHI:

CDG60_10635

ATG:	J4G44_11830

ACIU:

A3K93_14315

APOT:

MZO21_12250

PHA:

PSHAa1699

PTN:	PTRA_a2101(tmm)

PNG:	PNIG_a2218(tmm)

HTR:	EPV75_09255

MPIN:

LGT42_007885

MMAF:

GCM100_16730

MTHA:

VSX76_01845

HAF:	C8233_03960 C8233_04000

CMAI:

BFX80_07300 BFX80_07330

CAMH:

LCW13_07380 LCW13_07455

COBE:

CLAM6_13790 CLAM6_13880

COBB:

H2O77_07380

PAUR:

FGL86_11390

OAI:	OLEAN_C17270

MSEC:

LN244_01210

NIK:	F5I99_18960

OCE:

GU3_01635

OPE:	PU634_15295

OCM:	CBP12_10665

OPF:	CBP31_06935

IGN:	MMG00_06200

WCN:	PE074_07680

TSN:	W908_02175

THIN:

CRN91_07935

BUZ:	AYM40_12365

BAV:

BAV1821

BTRM:

SAMEA390648701700(hapE_2)

BOJ:	CBF45_10040

AALN:

Q3V95_02805

OUR:	CEQ07_03955

OUE:	I6G29_03005

KGY:	EHF36_10445

SIMP:

C6571_15265

LCH:

Lcho_0154

HAR:

HEAR2456

AON:	DEH84_17435

METR:

BSY238_2316

MEU:	ACJ67_08495

MLO:

mlr7328

MLN:	A9174_29045

MCI:	Mesci_5141

MCIC:

A4R28_01390

MOP:	Mesop_5723

MAM:	Mesau_05218

MAMO:

A6B35_11145

MESW:

A9K65_028190

MESM:

EJ066_15735

MESP:

C1M53_18785

MHUA:

MCHK_0843

MJR:	EB229_29620

MERD:

EB233_25665

MOH:	IHQ72_30420

MMEI:

LRP31_29780

AAK:	AA2016_5256

AMIH:

CO731_04990(hapE_2)

AMIS:

Amn_09760

ANJ:

AMD1_4801

PHT:	BLM14_24635

SME:

SMc04149

SMK:	Sinme_3434

SMQ:	SinmeB_3209

SMX:	SM11_chr3574

SMI:	BN406_03237

SMEG:

C770_GR4Chr0110

SMEL:

SM2011_c04149

SMER:

DU99_00555

SMD:

Smed_3315

SIX:	BSY16_5790

EAK:	EKH55_4287

SKM:	PZL22_003718

RET:	RHE_PE00411

REL:	REMIM1_PD00433

RLE:

pRL110548

RLT:	Rleg2_5648

RLG:

Rleg_6584

RLB:	RLEG3_05370

RLU:	RLEG12_01995

RTR:	RTCIAT899_PC09260

RHL:	LPU83_pLPU83c0701

RJG:	CCGE525_22880

RHR:	CKA34_31875

RAD:	CO657_28960

RII:	FFM53_030575

RHID:

FFM81_029920

RLN:	J0663_26905

RBAN:

J2J98_25845

RRG:	J3P73_30890

RLS:	HB780_09375

RAW:	NE851_05375

RLW:	RlegWSM1455_31260

RRHO:

PR018_16685

RTU:	PR017_16575

ARA:

Arad_8377

RBW:	RLCC275e_30195

AZC:

AZC_1374

LNE:	FZC33_22020

MOG:	MMB17_17390

MSL:

Msil_3604

MTUN:

MTUNDRAET4_3218

BBAR:

RHAL1_03796

HMC:	HYPMC_2735

METG:

HT051_12810

CMET:

K6K41_17915

AUZ:	Sa4125_10150

NOH:	G5V57_22945

LIZ:	LGH83_08190

BNE:	DA69_09200

BDM:	EQG53_06870

SIL:	SPO1551(tmm)

RDE:

RD1_0632

RLI:	RLO149_c005810

OAR:	OA238_c26840

LMD:	METH_18525

LEJ:	ETW24_18045

LAQU:

R2C4_19660

LEV:	ETW23_00115

LCAE:

K3721_16315

RED:	roselon_03573

CID:

P73_0139

CEH:	CEW89_17235

TPRO:

Ga0080559_TMP4888

PABY:

Ga0080574_TMP1125

SULZ:

C1J03_14655

RMM:	ROSMUCSMR3_00018

ROK:	RAK1035_2867

RID:	RIdsm_02096(hapE_4)

ROM:	EI983_08850

ROH:	FIU89_06135(hapE)

MALU:

KU6B_39800

PALX:

GQA70_23315

RHP:	LPB142_05620

PAMI:

JCM7686_pAMI6p076 JCM7686_pAMI6p102

PYE:	A6J80_01575

PZH:	CX676_01820

PAMN:

pAMV1p0112(tmm)

PSAP:

JHX88_20405

PALP:

JHW40_18575

DAA:	AKL17_0587

RBG:	BG454_03475

GEH:	HYN69_06775

GFU:	KM031_03475

TAW:	EI545_08500

PSEB:

EOK75_16655

HDH:	G5B40_19235

FAP:	GR316_12235

AMYL:

QBD29_01395

SSAN:

NX02_15600

GBE:	GbCGDNIH1_1825

GBH:	GbCGDNIH2_1825

GBC:	GbCGDNIH3_1825

GBS:	GbCGDNIH4_1825

GXL:

H845_65

KEU:	S101446_00773

AACE:

A0U92_02465

ACEK:

FLP30_07305

NGU:	QN315_14165

TII:	DY252_08080

THAI:

IT893_13180

TTB:	MACH01_26150

PUB:	SAR11_1296

PEG:	E5R92_06770

APC:	HIMB59_00013340

APM:	HIMB5_00009280

MXA:

MXAN_0506

MYX:	QEG98_02965

PIJ:	QEJ31_11555

MDX:	BTO20_34855

MADI:

A7U43_20125

MVA:

Mvan_1201

MGI:

Mflv_5135

MSP:	Mspyr1_45550

MPHL:

MPHLCCUG_02553(pamO_2)

MVQ:

MYVA_1579

MHAS:

MHAS_01947(pamO_2)

MAUU:

NCTC10437_00993(hapE_2)

MMOR:

MMOR_34870

MTY:	MTOK_34480

MAUB:

MAUB_30960

MPOF:

MPOR_14890

MMAT:

MMAGJ_74100

MDF:	K0O62_10910

CGL:	Cgl1141(Cgl1141)

CGB:

cg1292

CGU:

WA5_1096

CGT:

cgR_1225

CGS:	C624_06545

CGG:	C629_06545

CGM:

cgp_1292

CGJ:

AR0_06205

CGQ:	CGLAR1_06070

CGX:	SB89_05950

CEF:

CE1213

CMD:	B841_04830

CHM:	B842_05140

CMQ:	B840_04730

CCJZ:

ccrud_05510

CSUR:

N24_1258

CCOE:

CETAM_05160

CFAC:

CFAEC_05505(hapE)

BFV:	C628_06180

RPY:	Y013_00300

RBY:	CEJ39_10890

RHQ:	IM25_14250

RRT:	4535765_01758(hapE_3)

RGOR:

NMQ04_07730

REQ:

REQ_34750

PDEF:

P9209_11170

GSI:	P5P27_05775

DPC:	A6048_14945

DKN:	NHB83_14480

TOY:	FO059_01870

SVD:	CP969_24485

SPRA:

CP972_27535

SRUG:

F0345_00290

MIP:	AXH82_07385

MWA:	E4K62_12875

MOY:	CVS54_00105(hapE)

MCAW:

F6J84_14810

MLZ:	F6J85_12255

MLIQ:

NMQ05_00450

MPAO:

IZR02_00650

MEST:

PTQ19_00380

MVD:	AWU67_07760

MSPO:

KXZ72_13180

SALC:

C2138_08735

LARI:

KI794_10670

LTN:	KVY00_13740

GSD:	M3M28_07820

LYH:	FrondiHNR_00175

ARM:

ART_3120

ARL:	AFL94_13965

ARE:	AL755_14080

AAQ:	AOC05_17140

ARW:	MB46_17795

ARY:	ATC04_03995

ARU:	ASPU41_06140

ARQ:	BWQ92_06315

ACRY:

AC20117_12870

ARTP:

E5206_06715

ASUF:

MNQ99_14805

APOA:

J0916_16120

PSUL:

AU252_13030

PSEY:

GU243_21735

AAI:	AARI_10490

GCR:	GcLGCM259_1571

GPR:	JQN66_13930

MYU:	M8233_09610

MLY:	CJ228_008120 CJ228_008125

MPOR:

KW076_03945

MTEU:

R3I42_09625

CIG:	E7744_01695

NOI:	FCL41_10090

ASEZ:

H9L21_03030

ADB:	NP095_02925

NAL:

B005_2927

SVI:	Svir_30590

DSL:	Dacsa_3562

THEU:

HPC62_19245

TOG:	HNI00_15925

TER:

Tery_0516

PSN:	Pedsa_0537

SHT:	KO02_08030

SMIZ:

4412673_01531(hapE)

SPSC:

E2P86_10340

AEV:	EI546_10020

POA:	CW731_04875

PUN:	NQP51_16600

MYR:	MYRA21_0771

MPW:

MPR_3295

MOD:	AS202_03260

MYZ:	BK054_03370

MOA:	I6I89_00305

MALS:

NWE55_05680

BIA:	GMA17_14435

WVI:	Weevi_1215

CSAL:

NBC122_01708(hapE)

CHRC:

QGN23_14245

CJG:	NCTC13459_01237(hapE)

CCAS:

EIB73_03325

CANT:

NCTC13489_02194(pamO)

KFA:	Q73A0000_12550

KAQ:	L0B70_02210

CBAU:

H1R16_00610

ESTE:

HNV03_09870

» show all

Reference

1 [PMID:4404764]

Authors

Large PJ, Boulton CA, Crabbe MJ

Title

The reduced nicotinamide-adenine dinucleotide phosphate- and oxygen-dependent N-oxygenation of trimethylamine by Pseudomonas aminovorans.

Journal

Biochem J 128:137P-138P (1972)
DOI:10.1042/bj1280137pb

Reference

2 [PMID:9417913]

Authors

Dolphin CT, Riley JH, Smith RL, Shephard EA, Phillips IR

Title

Structural organization of the human flavin-containing monooxygenase 3 gene (FMO3), the favored candidate for fish-odor syndrome, determined directly from genomic DNA.

Journal

Genomics 46:260-7 (1997)
DOI:10.1006/geno.1997.5031

Sequence

[hsa:2328]

Reference

3 [PMID:9536088]

Authors

Treacy EP, Akerman BR, Chow LM, Youil R, Bibeau C, Lin J, Bruce AG, Knight M, Danks DM, Cashman JR, Forrest SM

Title

Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication.

Journal

Hum Mol Genet 7:839-45 (1998)
DOI:10.1093/hmg/7.5.839

Sequence

[rno:84493]

Reference

4 [PMID:22006322]

Authors

Chen Y, Patel NA, Crombie A, Scrivens JH, Murrell JC

Title

Bacterial flavin-containing monooxygenase is trimethylamine monooxygenase.

Journal

Proc Natl Acad Sci U S A 108:17791-6 (2011)
DOI:10.1073/pnas.1112928108

Sequence

[msl:Msil_3604]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.13.148

IUBMB Enzyme Nomenclature:

1.14.13.148

ExPASy - ENZYME nomenclature database:

1.14.13.148

BRENDA, the Enzyme Database:

1.14.13.148

DBGET integrated database retrieval system