KEGG   ENZYME: 1.14.13.19
Entry
EC 1.14.13.19               Enzyme                                 
Name
taxifolin 8-monooxygenase;
taxifolin hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating)
Reaction(IUBMB)
taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O [RN:R03637 R03638]
Reaction(KEGG)
R03637 R03638
Substrate
taxifolin [CPD:C01617];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2,3-dihydrogossypetin [CPD:C03052];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A flavoprotein, converting a flavanol into a flavanone. Also acts on fustin, but not on catechin, quercetin or mollisacidin.
History
EC 1.14.13.19 created 1976
Reference
1  [PMID:4146277]
  Authors
Jeffrey AM, Knight M, Evans WC.
  Title
The bacterial degradation of flavonoids. Hydroxylation of the A-ring of taxifolin by a soil pseudomonad.
  Journal
Biochem J 130:373-81 (1972)
DOI:10.1042/bj1300373
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.19
IUBMB Enzyme Nomenclature: 1.14.13.19
ExPASy - ENZYME nomenclature database: 1.14.13.19
BRENDA, the Enzyme Database: 1.14.13.19
CAS: 39307-19-2

  All links  
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Protein sequence (9)   
   RefSeq(pep) (9)   
DNA sequence (50)   
   RefSeq(nuc) (18)   
   GenBank (16)   
   EMBL (16)   
All databases (71)   

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