Entry
Name
L-ornithine N5-monooxygenase (NADPH);
CchB;
ornithine hydroxylase;
EtcB;
PvdA;
Af-OMO;
dffA (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
L-ornithine,NADPH:oxygen oxidoreductase (N5-hydroxylating)
Reaction(IUBMB)
L-ornithine + NADPH + H+ + O2 = N5-hydroxy-L-ornithine + NADP+ + H2O [RN:
R10789 ]
Reaction(KEGG)
Substrate
Product
Comment
A flavoprotein (FAD). The enzyme is involved in biosynthesis of N5-hydroxy-L-ornithine, N5-formyl-N5-hydroxy-L-ornithine or N5-acetyl-N5-hydroxy-L-ornithine. These nonproteinogenic amino acids are building blocks of siderophores produced by some bacteria (e.g. Streptomyces coelicolor, Saccharopolyspora erythraea and Pseudomonas aeruginosa). The enzyme is specific for NADPH. cf. EC
1.14.13.196 , L-ornithine N5-monooxygenase [NAD(P)H].
History
EC 1.14.13.195 created 2014
Orthology
K10531 L-ornithine N5-monooxygenase
Genes
NTE : NEUTE1DRAFT118011(NEUTE1DRAFT_118011)
FPOA : FPOAC1_008308(SID1)
GLZ : GLAREA_03625 GLAREA_10971
TMF : EYB26_005647 EYB26_006632
TRG : TRUGW13939_01424 TRUGW13939_06139
CIM : CIMG_00943 CIMG_01432
CPW : CPC735_050030 CPC735_054050
PNO : SNOG_02137 SNOG_14364
BZE : COCCADRAFT_4131 COCCADRAFT_87296
BSC : COCSADRAFT_33257 COCSADRAFT_41988
BOR : COCMIDRAFT_36413 COCMIDRAFT_85330
AALT : CC77DRAFT_1020276 CC77DRAFT_929285
ARAB : EKO05_0004673 EKO05_0005863
ZTR : MYCGRDRAFT_36273(SIDA)
FFU : CLAFUR5_10737 CLAFUR5_12915
CBET : CB0940_04841 CB0940_06516
SCM : SCHCO_02604923(SCHCODRAFT_02604923)
SFJ : SAMEA4384070_1584(pvdA)
PLUM : A4R40_21135 A4R40_21165
PAEU : BN889_02614(pvdA_1)
PCQ : PcP3B5_25940(pvdA_1) PcP3B5_31400(pvdA_2)
PPUT : L483_19790 L483_23425
PSYI : MME58_00140 MME58_14345
PFL : PFL_4079(pvdA) PFL_4989
PPRC : PFLCHA0_c41380(pvdA1) PFLCHA0_c49650(pvdA2)
PPRO : PPC_4179(pvdA) PPC_4990
PMUD : NCTC8068_01949(pvdA)
PFW : PF1751_v1c34380(pvdA)
PEN : PSEEN0980 PSEEN3223(pvdA)
PPUU : PputUW4_01576(pvdA)
PSES : PSCI_2672(pvdA) PSCI_4170
PGG : FX982_01526 FX982_04458
PMOE : HV782_010465 HV782_017075
PPII : QL104_15490 QL104_21210
PXA : KSS93_13475 KSS93_14575 KSS93_18290
PSAM : HU731_005190 HU731_006580
PTW : TUM18999_33900(pvdA)
PTAE : NCTC10697_03110(pvdA)
PPAO : K3169_08795 K3169_14535 K3169_22000
ACX : Achr_38990 Achr_f2200
PRR : AT705_01595 AT705_10875
HAK : KO116_03393 KO116_03511
HAXI : HAALTHF_50910n(pvdA)
BMV : BMASAVP1_A1623(pvdA)
BML : BMA10229_A0286(pvdA)
BPM : BURPS1710b_2090(pvdA)
BPL : BURPS1106A_1944(mbaA)
PDIO : PDMSB3_2880.1(pvdA)
PLG : NCTC10937_03951(pvdA)
AVF : RvVAR031_pl04060(pvdA)
MTW : CQW49_08325 CQW49_23390
LMD : METH_16845 METH_16910
SPSE : SULPSESMR1_00173(pvdA)
PARH : I5S86_11280 I5S86_11855
MAUU : NCTC10437_03249(pvdA)
MANY : MANY_00020 MANY_54110
MSAL : DSM43276_01730(pvdA)
CBOV : CBOVI_00280(pvdA1) CBOVI_10155(pvdA2)
NAH : F5544_09835 F5544_10495 F5544_17620
RFA : A3L23_00820(pvdA_1) A3L23_04976(pvdA_2)
RCR : NCTC10994_02024(pvdA)
RKO : JWS14_26100 JWS14_40450
GPO : GPOL_c06260 GPOL_c23650
GOM : D7316_00964(pvdA_1) D7316_02895(pvdA_2)
TSM : ASU32_09495 ASU32_21060
TPUL : TPB0596_28380 TPB0596_40250
SCO : SCO0498(SCF34.17c) SCO6434(SC1A6.23)
SCB : SCAB_11961 SCAB_85521
SHO : SHJGH_1233 SHJGH_5940
SMAL : SMALA_0085 SMALA_7818 SMALA_8336
SSOI : I1A49_03850 I1A49_42940 I1A49_45420
SDV : BN159_4234 BN159_7519
STRP : F750_0234 F750_6700
SLV : SLIV_06255 SLIV_35450
SAMB : SAM23877_7032(cchB)
SCZ : ABE83_07140 ABE83_33455
SPAV : Spa2297_31055 Spa2297_33050
SGS : AVL59_10985 AVL59_31660
SALW : CP975_00190 CP975_27190
SPHW : NFX46_23425 NFX46_23585
SALL : SAZ_00240 SAZ_42565
SALF : SMD44_00705 SMD44_07444
SALJ : SMD11_0620 SMD11_2644(pvdA) SMD11_6331
SNZ : DC008_03490 DC008_26665
SGD : ELQ87_34835 ELQ87_35770
SGZ : C0216_10015 C0216_29520 C0216_29530
SVN : CP980_17935 CP980_17945
SAQU : EJC51_07395 EJC51_25350 EJC51_25360
SBY : H7H31_02510 H7H31_25435 H7H31_25440
SPHV : F9278_01960 F9278_45205
SCHA : CP983_20590 CP983_41495
SSPB : CP982_34370 CP982_39295
SNF : JYK04_00706(pvdA_1) JYK04_00736(pvdA_2) JYK04_04425(pvdA_3)
SBRO : GQF42_30020 GQF42_36675
SMOB : J7W19_01315 J7W19_13285
SGJ : IAG43_01645 IAG43_30915
SHK : J2N69_28790 J2N69_34375
SLF : JEQ17_08280 JEQ17_08310
SAOV : G3H79_04320 G3H79_35100
SYAN : NRK68_18495 NRK68_31145
SXT : KPP03845_103639(pvdA)
SJN : RI060_04625 RI060_05050 RI060_05580
SFP : QUY26_05440 QUY26_36975
STTN : BSL84_16200 BSL84_31125
STRZ : OYE22_02465 OYE22_24730 OYE22_24735
KAB : B7C62_01105 B7C62_31555
KIS : HUT16_02635 HUT16_07675 HUT16_35125
ABRY : NYE86_16230 NYE86_32835
DCO : SAMEA4475696_0059(pvdA)
AMAZ : LUW76_00565 LUW76_05415
NFS : OIE67_15300 OIE67_39270
FRE : Franean1_3060 Franean1_5949
AOI : AORI_3148(pvdA) AORI_3674
AJA : AJAP_19595 AJAP_20790 AJAP_23620
AMYC : CU254_13005 CU254_20495
AMYB : BKN51_10845 BKN51_19435
AAB : A4R43_02185 A4R43_37830
AORI : SD37_16055 SD37_18865
AACD : LWP59_02775 LWP59_10690
AROO : NQK81_04200 NQK81_06835
PSEA : WY02_00185 WY02_04945
PSEE : FRP1_08400 FRP1_29025
PSEH : XF36_12240 XF36_26580
PHH : AFB00_29225 AFB00_29605
APRE : CNX65_13480 CNX65_21050 CNX65_22345 CNX65_24945
AMI : Amir_2660 Amir_4206 Amir_4488 Amir_5066
KUT : JJ691_28920 JJ691_40650
KPHY : AOZ06_09315 AOZ06_46645
LED : BBK82_05315 BBK82_28215
ACTU : Actkin_00424(pvdA_1) Actkin_01208(pvdA_2) Actkin_01363(pvdA_3) Actkin_04192(pvdA_4)
ACTR : Asp14428_29190(pvdA) Asp14428_30130
ACTL : L3i22_035600 L3i22_066140
AOU : ACTOB_003517 ACTOB_007059
PLK : CIK06_08770 CIK06_16680
DFU : Dfulv_14775 Dfulv_34150
CCAZ : COUCH_06450 COUCH_31715
» show all
Taxonomy
Reference
Authors
Ge L, Seah SY
Title
Heterologous expression, purification, and characterization of an l-ornithine N(5)-hydroxylase involved in pyoverdine siderophore biosynthesis in Pseudomonas aeruginosa.
Journal
Sequence
Reference
Authors
Meneely KM, Lamb AL
Title
Biochemical characterization of a flavin adenine dinucleotide-dependent monooxygenase, ornithine hydroxylase from Pseudomonas aeruginosa, suggests a novel reaction mechanism.
Journal
Sequence
Reference
Authors
Pohlmann V, Marahiel MA
Title
Delta-amino group hydroxylation of L-ornithine during coelichelin biosynthesis.
Journal
Reference
Authors
Robbel L, Helmetag V, Knappe TA, Marahiel MA
Title
Consecutive enzymatic modification of ornithine generates the hydroxamate moieties of the siderophore erythrochelin.
Journal
Other DBs