KEGG   ENZYME: 1.14.13.209
Entry
EC 1.14.13.209              Enzyme                                 
Name
salicyloyl-CoA 5-hydroxylase;
sdgC (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
salicyloyl-CoA,NADH:oxygen oxidoreductase (5-hydroxylating)
Reaction(IUBMB)
2-hydroxybenzoyl-CoA + NADH + H+ + O2 = gentisyl-CoA + NAD+ + H2O [RN:R11056]
Reaction(KEGG)
R11056
Substrate
2-hydroxybenzoyl-CoA [CPD:C20394];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
gentisyl-CoA [CPD:C21081];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the bacterium Streptomyces sp. WA46, participates in a pathway for salicylate degradation. cf. EC 1.14.13.172, salicylate 5-hydroxylase.
History
EC 1.14.13.209 created 2015
Orthology
K21684  salicyloyl-CoA 5-hydroxylase
Genes
CSUR: N24_2624
CBRE: QP027_12180
RHQ: IM25_24405
SGRF: SGFS_096160
SCOE: CP976_04320
SLF: JEQ17_00280
SDEC: L3078_42040
SCOA: QU709_16610
STRZ: OYE22_24625
MTS: MTES_3603
ARTP: E5206_14855
AOD: Q8Z05_16750
APN: Asphe3_39870
PSUL: AU252_00400
NOW: GBF35_46430
AMQ: AMETH_3628
PDX: Psed_5066
PBRO: HOP40_29540
PPEL: H6H00_06880
KBU: Q4V64_05800
 » show all
Reference
1  [PMID:15006746]
  Authors
Ishiyama D, Vujaklija D, Davies J
  Title
Novel pathway of salicylate degradation by Streptomyces sp. strain WA46.
  Journal
Appl Environ Microbiol 70:1297-306 (2004)
DOI:10.1128/AEM.70.3.1297-1306.2004
  Sequence
[ag:BAC78378]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.209
IUBMB Enzyme Nomenclature: 1.14.13.209
ExPASy - ENZYME nomenclature database: 1.14.13.209
BRENDA, the Enzyme Database: 1.14.13.209

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Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (34)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (21)   
   KEGG MGENES (12)   
Protein sequence (58)   
   UniProt (57)   
   SWISS-PROT (1)   
DNA sequence (43)   
   GenBank (22)   
   EMBL (21)   
Protein domain (3)   
   InterPro (3)   
All databases (147)   

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