KEGG   ENZYME: 1.14.13.219
Entry
EC 1.14.13.219              Enzyme                                 
Name
resorcinol 4-hydroxylase (NADPH)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
resorcinol,NADPH:oxygen oxidoreductase (4-hydroxylating)
Reaction(IUBMB)
resorcinol + NADPH + H+ + O2 = hydroxyquinol + NADP+ + H2O [RN:R05249]
Reaction(KEGG)
R05249
Substrate
resorcinol [CPD:C01751];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
hydroxyquinol [CPD:C02814];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the bacterium Corynebacterium glutamicum, is a single-component hydroxylase. The enzyme has no activity with NADH. cf. EC 1.14.13.220, resorcinol 4-hydroxylase (NADH), and EC 1.14.14.27, resorcinol 4-hydroxylase (FADH2).
History
EC 1.14.13.219 created 2016
Pathway
ec00362  Benzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K20943  resorcinol 4-hydroxylase (NADPH)
Genes
PTRO: G5S35_15145
NARM: N7E01_02740
XDI: EZH22_02295 EZH22_05830
PPAN: ESD82_09910
PFEO: E3U26_16755
CGL: Cgl1158(Cgl1158)
CGB: cg1309
CGU: WA5_1111(MhpA)
CGT: cgR_1240
CGS: C624_06615(mhpA)
CGG: C629_06615(mhpA)
CGM: cgp_1309
CSUR: N24_1278(mhpA)
ROP: ROP_42950
RPSK: JWS13_43960
 » show all
Reference
1  [PMID:16963551]
  Authors
Huang Y, Zhao KX, Shen XH, Chaudhry MT, Jiang CY, Liu SJ
  Title
Genetic characterization of the resorcinol catabolic pathway in Corynebacterium glutamicum.
  Journal
Appl Environ Microbiol 72:7238-45 (2006)
DOI:10.1128/AEM.01494-06
  Sequence
[cgl:Cgl1158]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.219
IUBMB Enzyme Nomenclature: 1.14.13.219
ExPASy - ENZYME nomenclature database: 1.14.13.219
BRENDA, the Enzyme Database: 1.14.13.219

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (16)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (3)   
   InterPro (3)   
All databases (35)   

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